Sinteza i anthelmintičko djelovanje novih 2-supstituiranih-4,5-difenil imidazola

A series of 2-substituted-4,5-diphenyl imidazoles 1a-j were synthesized by refluxing benzil with different substituted aldehydes in the presence of ammonium acetate and glacial acetic acid. Structures of the synthesized compounds were confirmed on the basis of IR, 1H NMR and mass spectral data. Compounds 1a-j were screened for anthelmintic activity. Test results revealed that compounds showed paralysis time of 0.24 to 1.54 s and death time of 0.39 to 4.40 s while the standard drugs albendazole and piperazine citrate showed paralysis time of 0.54 and 0.58 s and death time of 2.16 and 2.47 s, respectively, at the same concentration of 1 % (m/V). Five compounds, 2-[2-hydroxyphenyl]-4,5-diphenyl imidazole (1b), 2-[3-methoxyphenyl]-4,5-diphenyl imidazole (1c), 2-[2-phenylethenyl]-4,5-diphenyl imidazole (1e), 2-[4-fluorophenyl]-4,5-diphenyl imidazole (1g) and 2-[3-nitrophenyl]-4,5-diphenyl imidazole (1h) showed significant anthelmintic activity compared to the standard drugs.Refluksiranjem benzila s različitim supstituiranim aldehidima u prisutnosti amonijeva acetata i ledene octene kiseline sintetizirana je serija 2-supstituiranih-4,5-difenil imidazola (1a-j). Strukture sintetiziranih spojeva potvrđene su IR, 1H NMR i masenom spektroskopijom. U testovima na anthelmintičko djelovanje određeno je vrijeme paralize 0,24 do 1,54 min i vrijeme smrti 0,39 do 4,40 min, dok standarni lijekovi albendazol i piperazin citrat imaju vrijeme paralize 0,54 i 0,58 min, a vrijeme smrti 2,16, odnosno 2,47 min pri istim koncentracijama (1 % m/V). Pet spojeva, 2-[2-hidroksifenil]-4,5-difenil imidazol (1b), 2-[3-metoksifenil]-4,5-difenil imidazol (1c), 2-[2-feniletenil]-4,5-difenil imidazol (1e), 2-[4-fluorofenil]-4,5-difenil imidazol (1g) i 2-[3-nitrofenil]-4,5-difenil imidazol (1h) pokazuju značajno anthelmintičko djelovanje u odnosnu na standardne lijekove

Diagenetic remobilization of rare earth elements in a sediment core from the central Indian basin

341-344Rare earth elements (REE) distribution in a 36 cm long sediment box core from the Central Indian Basin is studied. REE concentration is generally higher in the upper oxic zone than in intermediate suboxic zone suggesting REE diffusion upwards the sediment column and subsequent incorporation in the oxyhydroxide phase. The similarity in depth distribution of bulk REE concentration, solid Mn phase and micronodule abundance from the coarse fraction suggest that micronodules are one of the major component controlling the REE distribution in a sediment column

Synthesis and microbiological evaluation of 2-acetanilido-4-arylthiazole derivatives

1929-1932A series of compounds have been synthesized by reacting 2-amino 4-arylthiazole with different substituted acetanilides and chloroacetylation of 2-amino 4-arylthiazole or their substituted derivatives. Ten different substituted compounds synthesized out of the 2-acetanilido 4-arylthiazole derivatives and 2-pyrazine 4-arylthiazole have been evaluated for the antifungal and antibacterial activities. These compounds have showed moderate antibacterial and very good activity

Size, surface texture, chemical composition and mineralogy interrelations in ferromanganese nodules of central Indian Ocean

201-203Fiftyseven ferromanganese nodules, classified into 3 size class ( 4 cm diam.) class. These observations suggest that the smaller nodules appear to have been influenced more by diagenetic processes that the larger nodules

Geochemistry of deep-sea sediment cores from the Central Indian Ocean Basin

241-246Four sediment cores from the Central Indian Ocean Basin (CIOB) were studied to characterise the coarse fraction (<63 mu), transition metal and major oxide contents. Transition metals (Mn, Cu, Ni, Zn) show enrichment towards the surface, thought to be of diagenetic origin. Metals are supplied by upward migration from a suboxic to anoxic zone at an intermediate depth of 12-35 cm below the sediment-water interface in all the cores. Buried maxima in transition metal concentration at depth of 26-55 cm below the sediment-water interface may represent relict enrichments formed prior to the formation of suboxic to anoxic zone. R-mode factor analysis suggests that detrital and diagenetic/hydrogenous components are the two main sources of elements in these sediments. The terrigenous index factor [Al/(Al+Fe+Mn)] showed its maximum influence as far south as 14 degrees S from approximately 140 to 100 ky BP (last interglacial maxima). This might be related to discharge of large quantity of sediments by Ganges and Brahmaputra rivers during intensive monsoon in the Asian sub-continent during that period

Synthesis and evaluation of some novel substituted 1,3,4-oxadiazole and pyrazole derivatives for antitubercular activity

1453-1456A series of 1,3,4-oxadiazole and pyrazole derivatives have been synthesized and evaluated for antitubercular activity. All the structures of the newly synthesized compounds have been supported by IR, 1H NMR, MS and CHN analysis. All the compounds have shown promising antitubercular activity when compared with the standard drug Streptomycin