One-Pot Synthesis of 2-(Aryl/Alkyl)amino-3-cyanobenzobthiophenes and Their Hetero-Fused Analogues by Pd-Catalyzed Intramolecular Oxidative C�H Functionalization/Arylthiolation

We have developed a high-yielding synthesis for substituted 2-(aryl/alkyl)amino-3-cyanobenzobthiophenes and their hetero-fused analogues by using a palladium-catalyzed intramolecular oxidative C�H functionalization/arylthiolation reaction of in situ generated N-(alkyl/aryl)thioamides, prepared from readily available (hetero)arylacetonitriles and alkyl/aryl isothiocyanates. This protocol was then extended to the synthesis of amino-substituted benzothieno2,3-bquinolines by employing a triflic acid mediated intramolecular cyclocondensation of the prepared 2-arylamino-3-cyanobenzobthiophenes. © 2017 WILEY-VCH Verlag GmbH & Co. KGaA, Weinhei

Comparative study of titanium elastic nailing v/s dynamic compression plating for the management of fracture shaft of femur in adolescent age group

Background: Femoral fractures are one of the common long bones fractured in paediatric age group. Over the past 20 years, there has been a dramatic and sustained trend toward the operative stabilization of femoral shaft fractures in school-aged children. Femoral fracture demands stable fixation in adolescent.Methods: A retrospective cohort study was conducted in a tertiary care hospital. All children’s between the age 11 to 18 years with femur fracture managed with either TENS or dynamic compression plating between march 2014 to march 2017 were included into the study.Results: most common mode of injury was RTA. Middle third being the most common site for fracture. There was100% union in our study. The mean time of union in TENS group was 12 weeks and that of Plating group Was 13.1 weeks. Irritation at entry site was seen in 11 (22.9%) out of 48 patients. Malunion was seen in 9 out of 48 children’s in group a, whereas malunion in group b seen in 1 child. All the malunion was less than 5 degree and Varus being most common type of malunion. Limb length discrepancy in group A was observed in 5 patents (10.5%) out which 3 were shortening and 2 were lengthening. In group b 1pateint had shortening at end of follow up. In group B superficial infection was seen in 4 (15%) out of 33 children’s and in group A it was observed in 2 children’s (5%).Conclusions: we concluded that compression plating in adolescent age group especially older and obese children for the management fracture shaft of femur comparatively better than TENS.

In vitro effects of salinity and algae genera on the Rotifer (Brachionus plicatilis Muller 1786)

The marine rotifer Brachionus plicatilis is extensively used as a major live food in fish larvae culture all over the world. In the present study an attempt was made to find out the optimum salinity and feeding conditions for growth of the rotifer B. plicatilis. The rotifer was cultured using Batch culture method at four salinities ranges (20, 25, 30 and 35ppt) and was fed with 3 species of microalgae including, Nannochloropsis oculata, Isochrysis galbana and Chlorella sp. The difference between salinity was not significant (P>0.05) but there was a significant difference between the food types (P<0.05). In all of the experiments, the combined effect of salinity and algal type on rotifer growth were significant (P<0.05). The best result was observed in the experiment conducted at 35ppt salinity using N. oculata as the main food (378 ind/ml)

58Ni(n,p)58Co and 58Ni(n,2n)57Ni reactions at the neutron energy of 14.54 MeV with covariance analysis

241-245The 58Ni(n,p)58Co and 58Ni(n,2n)57Ni reactions cross sections have been estimated relative to 197Au(n,2n)196Au monitor reaction at the incident neutron energy of 14.54±0.0024 MeV from the D-T fusion nuclear reaction using Purnima neutron generator carried through methods of activation and off-line γ-ray spectrometry. The uncertainty propagation and correlation for measured cross sections have been estimated using covariance analysis through considering the partial uncertainties in different attributes. The present measured reaction cross sections data have been analyzed by comparing with the literature data, with various libraries of evaluated data, like ENDF/B-VIII.0, JEFF-3.3, JENDL/AD-2017, ROSFOND-2010 and TALYS-1.9 theoretical calculations

Interactive 4-D Visualization of Stereographic Images From the Double Orthogonal Projection

The double orthogonal projection of the 4-space onto two mutually perpendicular 3-spaces is a method of visualization of four-dimensional objects in a three-dimensional space. We present an interactive animation of the stereographic projection of a hyperspherical hexahedron on a 3-sphere embedded in the 4-space. Described are synthetic constructions of stereographic images of a point, hyperspherical tetrahedron, and 2-sphere on a 3-sphere from their double orthogonal projections. Consequently, the double-orthogonal projection of a freehand curve on a 3-sphere is created inversely from its stereographic image. Furthermore, we show an application to a synthetic construction of a spherical inversion and visualizations of double orthogonal projections and stereographic images of Hopf tori on a 3-sphere generated from Clelia curves on a 2-sphere.Comment: ICGG 2020 submissio

2-(4-Isobutyl­phen­yl)-N′-[1-(4-nitro­phen­yl)ethyl­idene]propanohydrazide

The mol­ecule of the title compound, C21H25N3O3, exists in a trans configuration with respect to the ethyl­idene unit. The dihedral angle between the two substituted benzene rings is 86.99 (7)°. The nitro group is twisted from the attached benzene ring at an angle of 17.02 (7)°. In the crystal structure, mol­ecules are linked by pairs of N—H⋯O hydrogen bonds in a face-to-face manner into centrosymmetric dimers. These dimer units are further linked into chains along the c axis by weak C—H⋯O inter­actions. These chains are stacked along the b axis. The crystal is further stabilized by weak C—H⋯π inter­actions

Measurement of 92Mo(n,α)89Zr and 97Mo(n,p)97Nb reactions at the neutron energy 13.52 MeV with covariance analysis

218-222The cross sections have been estimated for the Nuclear reactions 92Mo(n,α)89Zr and 97Mo(n,p)97Nb produced in Purnima neutron generator at neutron energy of 13.52±0.0045 MeV using activation analysis and off-line γ -ray spectrometric techniques. 27Al(n,α)24Na has been used as a monitor reaction. The covariance analysis for these cross sections has been carried out by taking into consideration of partial uncertainties of different attributes and correlations between the attributes. The cross section values of the present study have been compared with EXFOR, ENDF data of various libraries and theoretical data of TALYS-1.8 code

Initiation codon mutation in βB1-crystallin (CRYBB1) associated with autosomal recessive nuclear pulverulent cataract

PurposeTo identify the molecular basis for autosomal recessively inherited congenital non-syndromic pulverulent cataracts in a consanguineous family with four affected children.MethodsAn autozygosity mapping strategy using high density SNP microarrays and microsatellite markers was employed to detect regions of homozygosity. Subsequently good candidate genes were screened for mutations by direct sequencing.ResultsThe SNP microarray data demonstrated a 24.96 Mb region of homozygosity at 22q11.21-22q13.2 which was confirmed by microsatellite marker analysis. The candidate target region contained the beta-crystallin gene cluster and direct sequencing in affected family members revealed a novel mutation in CRYBB1 (c.2T&gt;A; p.Met1Lys).ConclusionsTo our knowledge this is the first case of an initiation codon mutation in a human crystallin gene, and only the second report of a CRYBB1 mutation associated with autosomal recessive congenital cataracts. In addition, although a number of genetic causes of autosomal dominant pulverulent cataracts have been identified (including CRYBB1) this is the first gene to have been implicated in autosomal recessive nuclear pulverulent cataract