235 research outputs found
Unraveling the Composition of Rembrandt's Impasto through the Identification of Unusual Plumbonacrite by Multimodal X-ray Diffraction Analysis
Unraveling the Composition of Rembrandt's Impasto through the Identification of Unusual Plumbonacrite by Multimodal X‐ray Diffraction Analysis
Studies of the ambient light of deep Baikal waters with Baikal-GVD
The Baikal-GVD neutrino detector is a deep-underwater neutrino telescope
under construction and recently after the winter 2023 deployment it consists of
3456 optical modules attached on 96 vertical strings. This 3-dimensional array
of photo-sensors allows to observe ambient light in the vicinity of the
Baikal-GVD telescope that is associated mostly with water luminescence. Results
on time and space variations of the luminescent activity are reviewed based on
data collected in 2018-2022
Search for directional associations between Baikal Gigaton Volume Detector neutrino-induced cascades and high-energy astrophysical sources
Baikal-GVD has recently published its first measurement of the diffuse
astrophysical neutrino flux, performed using high-energy cascade-like events.
We further explore the Baikal-GVD cascade dataset collected in 2018-2022, with
the aim to identify possible associations between the Baikal-GVD neutrinos and
known astrophysical sources. We leverage the relatively high angular resolution
of the Baikal-GVD neutrino telescope (2-3 deg.), made possible by the use of
liquid water as the detection medium, enabling the study of astrophysical point
sources even with cascade events. We estimate the telescope's sensitivity in
the cascade channel for high-energy astrophysical sources and refine our
analysis prescriptions using Monte-Carlo simulations. We primarily focus on
cascades with energies exceeding 100 TeV, which we employ to search for
correlation with radio-bright blazars. Although the currently limited neutrino
sample size provides no statistically significant effects, our analysis
suggests a number of possible associations with both extragalactic and Galactic
sources. Specifically, we present an analysis of an observed triplet of
neutrino candidate events in the Galactic plane, focusing on its potential
connection with certain Galactic sources, and discuss the coincidence of
cascades with several bright and flaring blazars.Comment: 10 pages, 3 figure
Monitoring of optical properties of deep waters of Lake Baikal in 2021-2022
We present the results of the two-year (2021-2022) monitoring of absorption
and scattering lengths of light with wavelength 400-620 nm within the effective
volume of the deep underwater neutrino telescope Baikal-GVD, which were
measured by a device Baikal-5D No.2. The Baikal-5D No.2. was installed during
the 2021 winter expedition at a depth of 1180 m. The absorption and scattering
lengths were measured every week in 9 spectral points. The device Baikal-5D
No.2 also has the ability to measure detailed scattering and absorption
spectra. The data obtained make it possible to estimate the range of changes in
the absorption and scattering lengths over a sufficiently long period of time
and to investigate the relationship between the processes of changes in
absorption and scattering. An analysis was made of changes in absorption and
scattering spectra for the period 2021-2022
Large neutrino telescope Baikal-GVD: recent status
The Baikal-GVD is a deep-underwater neutrino telescope being constructed in
Lake Baikal. After the winter 2023 deployment campaign the detector consists of
3456 optical modules installed on 96 vertical strings. The status of the
detector and progress in data analysis are discussed in present report. The
Baikal-GVD data collected in 2018-2022 indicate the presence of cosmic neutrino
flux in high-energy cascade events consistent with observations by the IceCube
neutrino telescope. Analysis of track-like events results in identification of
first high-energy muon neutrino candidates. These and other results from
2018-2022 data samples are reviewed in this report
Age-Related Attenuation of Dominant Hand Superiority
The decline of motor performance of the human hand-arm system with age is well-documented. While dominant hand performance is superior to that of the non-dominant hand in young individuals, little is known of possible age-related changes in hand dominance. We investigated age-related alterations of hand dominance in 20 to 90 year old subjects. All subjects were unambiguously right-handed according to the Edinburgh Handedness Inventory. In Experiment 1, motor performance for aiming, postural tremor, precision of arm-hand movement, speed of arm-hand movement, and wrist-finger speed tasks were tested. In Experiment 2, accelerometer-sensors were used to obtain objective records of hand use in everyday activities
Efficacy of Baricitinib in the Treatment of Chilblains Associated With Aicardi-Goutieres Syndrome, a Type I Interferonopathy
Genetics of disease, diagnosis and treatmen
Coffee, tea and decaffeinated coffee in relation to hepatocellular carcinoma in a European population: multicentre, prospective cohort study
Inverse associations of coffee and/or tea in relation to hepatocellular carcinoma (HCC) risk have been consistently identified in studies conducted mostly in Asia where consumption patterns of such beverages differ from Europe. In the European Prospective Investigation into Cancer and nutrition (EPIC), we identified 201 HCC cases among 486,799 men/women, after a median follow-up of 11 years. We calculated adjusted hazard ratios (HR) for HCC incidence in relation to quintiles/categories of coffee/tea intakes. We found that increased coffee and tea intakes were consistently associated with lower HCC risk. The inverse associations were substantial, monotonic and statistically significant. Coffee consumers in the highest compared to the lowest quintile had lower HCC risk by 72% (HR: 0.28; 95% confidence intervals (CI): 0.16 to 0.50, P-trend <0.001). The corresponding association of tea with HCC risk was 0.41 (95% CI: 0.22 to 0.78, P-trend=0.003). There was no compelling evidence of heterogeneity of these associations across strata of important HCC risk factors, including hepatitis B or hepatitis C status (available in a nested case-control study). The inverse, monotonic associations of coffee intake with HCC were apparent for caffeinated (P-trend=0.009), but not decaffeinated (P-trend=0.45) coffee for which, however, data were available for a fraction of subjects. Results from this multi-centre, European cohort study strengthen the existing evidence regarding the inverse association between coffee/tea and HCC risk. Given the apparent lack of heterogeneity of these associations by HCC risk factors and that coffee/tea are universal exposures, our results could have important implications for high HCC risk subjects
Value of hospital antimicrobial stewardship programs [ASPs]:a systematic review
Abstract Background Hospital antimicrobial stewardship programs (ASPs) aim to promote judicious use of antimicrobials to combat antimicrobial resistance. For ASPs to be developed, adopted, and implemented, an economic value assessment is essential. Few studies demonstrate the cost-effectiveness of ASPs. This systematic review aimed to evaluate the economic and clinical impact of ASPs. Methods An update to the Dik et al. systematic review (2000–2014) was conducted on EMBASE and Medline using PRISMA guidelines. The updated search was limited to primary research studies in English (30 September 2014–31 December 2017) that evaluated patient and/or economic outcomes after implementation of hospital ASPs including length of stay (LOS), antimicrobial use, and total (including operational and implementation) costs. Results One hundred forty-six studies meeting inclusion criteria were included. The majority of these studies were conducted within the last 5 years in North America (49%), Europe (25%), and Asia (14%), with few studies conducted in Africa (3%), South America (3%), and Australia (3%). Most studies were conducted in hospitals with 500–1000 beds and evaluated LOS and change in antibiotic expenditure, the majority of which showed a decrease in LOS (85%) and antibiotic expenditure (92%). The mean cost-savings varied by hospital size and region after implementation of ASPs. Average cost savings in US studies were 2.50 to $2640), with similar trends exhibited in European studies. The key driver of cost savings was from reduction in LOS. Savings were higher among hospitals with comprehensive ASPs which included therapy review and antibiotic restrictions. Conclusions Our data indicates that hospital ASPs have significant value with beneficial clinical and economic impacts. More robust published data is required in terms of implementation, LOS, and overall costs so that decision-makers can make a stronger case for investing in ASPs, considering competing priorities. Such data on ASPs in lower- and middle-income countries is limited and requires urgent attention
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