Membrane lipid therapy: Modulation of the cell membrane composition and structure as a molecular base for drug discovery and new disease treatment.

Nowadays we understand cell membranes not as a simple double lipid layer but as a collection of complex and dynamic protein-lipid structures and microdomains that serve as functional platforms for interacting signaling lipids and proteins. Membrane lipids and lipid structures participate directly as messengers or regulators of signal transduction. In addition, protein-lipid interactions participate in the localization of signaling protein partners to specific membrane microdomains. Thus, lipid alterations change cell signaling that are associated with a variety of diseases including cancer, obesity, neurodegenerative disorders, cardiovascular pathologies, etc. This article reviews the newly emerging field of membrane lipid therapy which involves the pharmacological regulation of membrane lipid composition and structure for the treatment of diseases. Membrane lipid therapy proposes the use of new molecules specifically designed to modify membrane lipid structures and microdomains as pharmaceutical disease-modifying agents by reversing the malfunction or altering the expression of disease-specific protein or lipid signal cascades. Here, we provide an in-depth analysis of this emerging field, especially its molecular bases and its relevance to the development of innovative therapeutic approaches

UV and IR Spectroscopy of Metal Ion-Crown Ether Complexes in the Gas Phase

Seventh International Conference on Advanced Vibrational Spectroscopy (ICAVS-7), 2013年8月25日-30日, 神戸国際会議

Cold Spectroscopy of Metal Ion-Crown Ether Complexes in the Gas Phase

Seventh International Conference on Advanced Vibrational Spectroscopy (ICAVS-7), 2013年8月25日-30日, 神戸国際会議

極低温イオントラップ中の金属イオン－クラウンエーテル錯体のレーザー分光

第5回分子科学討論会, 2011年9月20日-23日, 札幌コンベンションセンター(札幌

UV and IR spectroscopic studies of metal ion-crown ether complexes in the gas phase and on gold surface

Gordon Research Conferences –Molecular & Ionic Clusters, from April 27 to May 2, 2014, Renaissance Tuscany Il Ciocco, in Lucca (Barga), Ital

UV and IR Spectroscopic Studies of Cold Alkali Metal Ion-Benzo Crown Ether Complexes in the Gas Phase

International Symposium on Molecular Spectroscopy, from June 18 to June 22, 2012, at Ohio State University, in Columbus, Ohio, US

UV AND IR SPECTROSCOPIC STUDIES OF COLD ALKALI METAL ION-BENZO CROWN ETHER COMPLEXES IN THE GAS PHASE

Author Institution: Department of Chemistry, Faculty of Science, Hiroshima University, Higashi-Hiroshima 739-8526, Japan; Laboratoire de Chimie Physique Moleculaire, Ecole Polytechnique Federale de Lausanne, Lausanne CH-1015, Switzerland; Department of Chemistry, Faculty of Science, Hiroshima University, Higashi-Hiroshima 739-8526, Japan; Department of Chemistry, Faculty of Science, Hiroshima University, Higashi-Hiroshima 739-8526, Japan; Department of Chemistry, Faculty of Science, Hiroshima University, Higashi-Hiroshima 739-8526, Japan; Laboratoire de Chimie Physique Moleculaire, Ecole Polytechnique Federale de Lausanne, Lausanne CH-1015, SwitzerlandWe measured UV photodissociation and IR-UV double-resonance spectra of benzo-crown ether complexes with alkali metal ions (Li$^{+}$, Na$^{+}$, K$^{+}$, Rb$^{+}$, and Cs$^{+}$) in a cold, 22-pole ion trap nderline{\textbf{133}}(31), 12256 July 2011.}. All the complexes show a number of vibronically resolved UV bands in the 36000-38000 cm$^{-1}$ region. We used the IR-UV spectra in the CH stretching region to distinguish peaks in the UV spectra that belong to different conformers. The use of density functional theory allows us to determine the conformation of the complexes

UV and IR Spectroscopic Studies of Cold Alkali Metal Ion-Benzo Crown Ether Complexes in the Gas Phase

International Symposium on Molecular Spectroscopy, from June 18 to June 22, 2012, at Ohio State University, in Columbus, Ohio, US

UV and IR spectroscopic studies of alkali metal ion-crown ether complexes in the gas phase and on gold surface

Gordon Research Conferences –Molecular & Ionic Clusters, from April 27 to May 2, 2014, Renaissance Tuscany Il Ciocco, in Lucca (Barga), Ital