Heating and Cooling of Hot Accretion Flows by Non Local Radiation

We consider non-local effects which arise when radiation emitted at one radius of an accretion disk either heats or cools gas at other radii through Compton scattering. We discuss three situations: 1. Radiation from the inner regions of an advection-dominated flow Compton cooling gas at intermediate radii and Compton heating gas at large radii. 2. Soft radiation from an outer thin accretion disk Compton cooling a hot one- or two-temperature flow on the inside. 3. Soft radiation from an inner thin accretion disk Compton cooling hot gas in a surrounding one-temperature flow. We describe how previous results are modified by these non-local interactions. We find that Compton heating or cooling of the gas by the radiation emitted in the inner regions of a hot flow is not important. Likewise, Compton cooling by the soft photons from an outer thin disk is negligible when the transition from a cold to a hot flow occurs at a radius greater than some minimum $R_{tr,min}$. However, if the hot flow terminates at $R < R_{tr,min}$, non-local cooling is so strong that the hot gas is cooled to a thin disk configuration in a runaway process. In the case of a thin disk surrounded by a hot one-temperature flow, we find that Compton cooling by soft radiation dominates over local cooling in the hot gas for \dot{M} \gsim 10^{-3} \alpha \dot{M}_{Edd}, and R \lsim 10^4 R_{Schw}. As a result, the maximum accretion rate for which an advection-dominated one-temperature solution exists, decreases by a factor of $\sim 10$, compared to the value computed under an assumption of local energy balance.Comment: LaTeX aaspp.sty, 25 pages, and 6 figures; to appear in Ap

A Decade Of Starspot Activity On The Eclipsing Short-Period RS Canum Venaticorum Star WY Cancri: 1988-1997

We present optical photometry of the short-period eclipsing RS CVn system WY Cancri for the years 1988–1997. For each light curve, we model the distortion waves in order to study the behavior of starspots in this system. After removing the spot effects f

A rare case of endometriosis to clear cell ovarian carcinoma: a case report

Clear cell carcinoma of ovary is a rare tumour with a very low incidence in pregnancy. It is attributed to develop from an existing background of endometriosis. There are very few case reports of the above combination tumours in pregnancy. It is a very aggressive tumour with a worse prognosis and low survival rate because of its peculiar chemo resistant nature. Early detection and effective treatment are the best approach. The treatment options for advanced stages are still under research

A New Angle on Intersecting Branes in Infinite Extra Dimensions

I construct solutions to Einstein's equations in 6 dimensions with bulk cosmological constant and intersecting 4-branes. Solutions exist for a continuous range of 4-brane tension, with long distance gravity localized to a 3+1 dimensional Minkowski intersection, provided that the additional tension of the intersection satisfies one condition.Comment: Latex, Bibtex, 8 pages, references adde

Has the phasing out of stavudine in accordance with changes in WHO guidelines led to a decrease in single-drug substitutions in first-line antiretroviral therapy for HIV in sub-Saharan Africa?

This version is the Accepted Manuscript and is published in final edited form as: AIDS. 2017 January 02; 31(1): 147–157. doi:10.1097/QAD.0000000000001307OBJECTIVE: We assessed the relationship between phasing out stavudine in first-line antiretroviral therapy (ART) in accordance with WHO 2010 policy and single-drug substitutions (SDS) (substituting the nucleoside reverse transcriptase inhibitor in first-line ART) in sub-Saharan Africa. DESIGN: Prospective cohort analysis (International epidemiological Databases to Evaluate AIDS-Multiregional) including ART-naive, HIV-infected patients aged at least 16 years, initiating ART between January 2005 and December 2012. Before April 2010 (July 2007 in Zambia) national guidelines called for patients to initiate stavudine-based or zidovudine-based regimen, whereas thereafter tenofovir or zidovudine replaced stavudine in first-line ART. METHODS: We evaluated the frequency of stavudine use and SDS by calendar year 2004-2014. Competing risk regression was used to assess the association between nucleoside reverse transcriptase inhibitor use and SDS in the first 24 months on ART. RESULTS: In all, 33 441 (8.9%; 95% confience interval 8.7-8.9%) SDS occurred among 377 656 patients in the first 24 months on ART, close to 40% of which were amongst patients on stavudine. The decrease in SDS corresponded with the phasing out of stavudine. Competing risks regression models showed that patients on tenofovir were 20-95% less likely to require a SDS than patients on stavudine, whereas patients on zidovudine had a 75-85% decrease in the hazards of SDS when compared to stavudine. CONCLUSION: The decline in SDS in the first 24 months on treatment appears to be associated with phasing out stavudine for zidovudine or tenofovir in first-line ART in our study. Further efforts to decrease the cost of tenofovir and zidovudine for use in this setting is warranted to substitute all patients still receiving stavudine

Disruption of the Suprachiasmatic Nucleus in Fibroblast Growth Factor Signaling-Deficient Mice.

Fibroblast growth factor (Fgf) 8 is essential for the development of multiple brain regions. Previous studies from our laboratory showed that reduced Fgf8 signaling led to the developmental alterations of neuroendocrine nuclei that originated within the diencephalon, including the paraventricular (PVN) and supraoptic (SON) nuclei. To further understand the role of Fgf8 in the development of other hypothalamic nuclei, we examined if Fgf8 and its cognate receptor, Fgfr1, also impact the integrity of the suprachiasmatic nuclei (SCN). The SCN control an organism's circadian rhythm and contain vasoactive intestinal peptide (VIP)-producing neurons as the main input neurons. Mice hypomorphic for Fgf8, Fgfr1, or both were examined for their SCN volume and the number of VIP neurons on postnatal day (PN) 0; adult hypomorphic mice were further examined for SCN function by quantifying SCN neuronal activation using cFos as a marker. On PN0, mice homozygous for Fgf8 hypomorphy displayed the most severe reduction of the SCN volume and VIP neurons. Those heterozygous for Fgf8 hypomorphy alone or Fgf8 combined with Fgfr1 hypomorphy, called double heterozygotes (DH), showed normal SCN volume but significantly reduced VIP neurons, albeit less severely than the homozygotes. Adult wild type, heterozygous Fgf8 hypomorphs (F8 Het), and DH mice were also examined for SCN cFos activation at three time points: 1 h (morning), 6 h (afternoon), and 11 h (evening) after light onset. In F8 Het mice, a significant change in the pattern of cFos immunostaining that may reflect delayed morning SCN activation was observed. Overall, our studies provide evidence supporting that deficiencies in Fgf8 not only impact the structural integrity of the SCN but also the pattern of SCN activation in response to light

A Solution to the Hierarchy Problem with an Infinitely Large Extra Dimension and Moduli Stabilization

We construct a class of solutions to the Einstein's equations for dimensions greater than or equal to six. These solutions are characterized by a non-trivial warp factor and possess a non-compact extra dimension. We study in detail a simple model in six dimensions containing two four branes. One of each brane's four spatial directions is compactified. The hierarchy problem is resolved by the enormous difference between the warp factors at the positions of the two branes, with the standard model fields living on the brane with small warp factor. Both branes can have positive tensions. Their positions, and the size of the compact dimension are determined in terms of the fundamental parameters of the theory by a combination of two independent and comparable effects---an anisotropic contribution to the stress tensor of each brane from quantum fields living on it and a contribution to the stress tensor from a bulk scalar field. One overall fine tuning of the parameters of the theory is required ---that for the cosmological constant.Comment: 16 pages 1 figure. Conclusion about naturalness of hierarchy without bulk interactions changed. Section added on obtaining a natural hierarchy with bulk scalar field. References added. Minor editin

Slightly Non-Minimal Dark Matter in PAMELA and ATIC

We present a simple model in which dark matter couples to the standard model through a light scalar intermediary that is itself unstable. We find this model has several notable features, and allows a natural explanation for a surplus of positrons, but no surplus of anti-protons, as has been suggested by early data from PAMELA and ATIC. Moreover, this model yields a very small nucleon coupling, well below the direct detection limits. In this paper we explore the effect of this model in both the early universe and in the galaxy.Comment: 7 pages, 6 figures, v3: updated for new data, added discussion of Ferm