Molecular Complexation of Hederasaponin C with Cholesterol in Aqueous Isopropyl Alcohol

The 1:1 molecular complex of ivy triterpene glycoside hederasaponin C (HedC) with cholesterol (Chol) was obtained in aqueous isopropyl alcohol. The stability constant of (3.3 ± 0.7)∙106 (mol/L)–1 was calculated for the complex. The complexation was studied by UV- and ATR IR-Fourier spectroscopy, and method of isomolar series. The hydrogen bonds and hydrophobic interactions are formed in the molecular complex

Molecular Complexation of Hederasaponin C with Cholesterol in Aqueous Isopropyl Alcohol

The 1:1 molecular complex of ivy triterpene glycoside hederasaponin C (HedC) with cholesterol (Chol) was obtained in aqueous isopropyl alcohol. The stability constant of (3.3 ± 0.7)∙106 (mol/L)–1 was calculated for the complex. The complexation was studied by UV- and ATR IR-Fourier spectroscopy, and method of isomolar series. The hydrogen bonds and hydrophobic interactions are formed in the molecular complex

Intermolecular Interaction of Glycyrrhizin with Cholesterol

Received: 27.10.2020. Accepted: 09.12.2020. Published:30.12.2020.The 1:1 molecular complex of licorice triterpene glycoside glycyrrhizic acid (in the form of monoammonium salt) with cholesterol was obtained in 80% aqueous isopropyl alcohol for the first time. The complexation was studied by 13C NMR, UV, and ATR IR-Fourier spectroscopy. The hydrogen bonds and hydrophobic interactions are formed in the molecular complex.This work was carried out in the frame of an internal grant of Sevastopol State University (identifier 30/06-31)

Иммуноглобулин G4-ассоциированные заболевания c поражением легких

Lung involvement in IgG-related diseases is poorly investigated. The current approach to IgG-related diseases including IgG-related lung disease was discussed in the article. The authors described recent classification and diagnostic criteria of IgG4-related lung disease, including radiological, serological and morphological parameters, and therapeutic approaches. Two clinical cases of IgG4-related disease with involvement of the lungs (organizing pneumonia), lacrimal glands (dacryoadenitis), kidneys (tubulointerstitial nephritis), eyes (iridocyclitis), and salivary glands (sialadenitis) were described in the article. Immunosuppressive therapy was successful in both cases. Среди всех IgG4-ассоциированных заболеваний (IgG4-АЗ) легочные поражения являются наименее изученными практическими врачами. В обзоре изложен современный взгляд на проблему IgG4-АЗ, в т. ч. с поражением легких. Подробно изложена современная классификация вариантов легочной патологии, а также диагностические критерии, включающие рентгенологические, серологические и морфологические параметры; рассмотрены подходы к лечению IgG4-АЗ легких. Приводятся 2 собственных клинических наблюдения IgG4-АЗ с поражением легких (организующаяся пневмония), слезных желез (дакриоаденит), почек (тубулоинтерстициальный нефрит), органа зрения (иридоциклит) и слюнных желез (сиалоаденит). Продемонстрированы хорошие результаты иммуносупрессивной терапии, проведенной в обоих случаях