On the order of an automorphism of a smooth hypersurface

In this paper we give an effective criterion as to when a positive integer q is the order of an automorphism of a smooth hypersurface of dimension n and degree d, for every d>2, n>1, (n,d)\neq (2,4), and \gcd(q,d)=\gcd(q,d-1)=1. This allows us to give a complete criterion in the case where q=p is a prime number. In particular, we show the following result: If X is a smooth hypersurface of dimension n and degree d admitting an automorphism of prime order p then p(d-1)^n then X is isomorphic to the Klein hypersurface, n=2 or n+2 is prime, and p=\Phi_{n+2}(1-d) where \Phi_{n+2} is the (n+2)-th cyclotomic polynomial. Finally, we provide some applications to intermediate jacobians of Klein hypersurfaces

Novel types of anti-ecloud surfaces

In high power RF devices for space, secondary electron emission appears as the main parameter governing the multipactor effect and as well as the e-cloud in large accelerators. Critical experimental activities included development of coatings with low secondary electron emission yield (SEY) for steel (large accelerators) and aluminium (space applications). Coatings with surface roughness of high aspect ratio producing the so-call secondary emission suppression effect appear as the selected strategy. In this work a detailed study of the SEY of these technological coatings and also the experimental deposition methods (PVD and electrochemical) are presented. The coating-design approach selected for new low SEY coatings include rough metals (Ag, Au, Al), rough alloys (NEG), particulated and magnetized surfaces, and also graphene like coatings. It was found that surface roughness also mitigate the SEY deterioration due to aging processes.Comment: 4 pages, contribution to the Joint INFN-CERN-EuCARD-AccNet Workshop on Electron-Cloud Effects: ECLOUD'12; 5-9 Jun 2012, La Biodola, Isola d'Elba, Italy; CERN Yellow Report CERN-2013-002, pp.153-15

Web-GIS approach to preventive conservation of heritage buildings

The effective implementation of preventive conservation approaches demands the employment of standardized and robust tools able to integrate the data coming from multiple sources, inspection and diagnosis techniques, as well as to ensure the proper information transfer between expert and non-expert users. Aiming to make a step forward in the state of the art of current conservation approaches, a cutting edge Web-GIS technology resorting to the intuitiveness of 360° panoramas and 3D point clouds in combination with the Internet of Things is presented in this work, demonstrating how physical and digital worlds can be linked for proper documentation and management of cultural heritage. To validate such a pioneering approach, one of the most representative and complex heritage buildings of Spain is used as a case study: the General Historical Library of Salamanca.This work was financed by ERDF funds through the V Sudoe Interreg program within the framework of the HeritageCare project (Ref. SOE1/P5/P0258), by project Patrimonio 5.0 (SA075P17), by FEDER funds through the Competitive Factors Operational Program (COMPETE) and by the Foundation for Science and Technology (FCT) within the scope of projects POCI-01-0145-FEDER-007633. The authors would like to express their gratitude to the personnel from the General Historical Library of the University of Salamanca as well as to the Centre for Computer Graphics of the University of Minho for the web implementation of the platform

Androgen receptor and its splicing variant 7 expression in peripheral blood mononuclear cells and in circulating tumor cells in metastatic castration-resistant prostate cancer

Androgen receptor (AR) signaling remains crucial in castration-resistant prostate cancer (CRPC). Since it is also essential in immune cells, we studied whether the expression of AR full-length (ARFL) and its splicing variant ARV7 in peripheral blood mononuclear cells (PBMC) predicts systemic treatment response in mCRPC in comparison with circulating-tumor cells (CTC). We measured ARFL and ARV7 mRNA in PBMC and CTC from patients prior to receiving abiraterone (AA), enzalutamide (E), or taxanes by a pre-amplification plus quantitative reverse-transcription PCR. They were also tested in LNCaP-ARV7-transfected and in 22RV1 docetaxel-resistant (22RV1DR) cells. We studied 171 PBMC from 136 patients and from 24 non-cancer controls, and 47 CTC from 22 patients. High PBMC ARV7 levels correlated with worse AA/E and better taxane response. In taxane-treated patients high PBMC ARFL also correlated with longer progression-free survival (PFS). High ARV7 and ARFL expression were independently associated with better biochemical-PFS. Conversely, high CTC ARV7 and ARFL correlated with shorter radiological-PFS and overall survival, respectively. High ARV7 in 22RV1DR and LNCaP-ARV7 cells correlated with taxane resistance. In conclusion, ARFL and ARV7 at PBMC or CTC have a different predictive role in the taxane response, suggesting a potential influence of the AR pathway from PBMC in such response modulation

Q ITESO: Análisis Crítico de Medios

En esta séptima entrega de Q ITESO: Análisis Crítico de Medios se examina un 2014 colmado de acontecimientos sobre la reconfiguración de los medios de Jalisco y del país, y sus relaciones con el estado, los empresarios y el público. Destaca la aprobación de la Ley Federal de Telecomunicaciones y Radiocomunicación y los nuevos equilibrios de poder que esto supone. También, se analizan las alianzas de algunos diarios nacionales y del estado con medios extranjeros, para compensar algunas carencias y ampliar su oferta editorial e informativa. Otras cuestiones no menos relevantes tienen que ver con la libertad de expresión y la inseguridad laboral en la que viven muchos trabajadores de los medios de comunicación jaliscienses, sobre todo los impresos, y el caso emblemático del llamado “cuarto de guerra” al servicio del gobernador del estado, Aristóteles Sandoval, para espiar -y en ocasiones hasta coaccionar- a directivos y reporteros de medios para atenuar la crítica al gobierno. El derecho a la información, la transparencia, la situación de los nuevos medios en línea, los periodistas que publican libros, el cambio climático y los periodistas que ya no están con nosotros merecen también una mirada atenta en este informe.ITESO, A.C

ANGPTL-4 is associated with obesity and lipid profile in children and adolescents

Angiopoietin-like protein 4 (ANGPTL-4) regulates lipidic metabolism and a_ects energy homeostasis. However, its function in children with obesity remains unknown. We investigated plasma ANGPTL-4 levels in children and its relationship with body mass index (BMI) and di_erent lipidic parameters such as free fatty acids (FFA). Plasma ANGPTL-4 levels were analyzed in two di_erent cohorts. In the first cohort (n = 150, age 3-17 years), which included children with normal weight or obesity, we performed a cross-sectional study. In the second cohort, which included only children with obesity (n = 20, age 5-18 years) followed up for two years after an intervention for weight loss, in which we performed a longitudinal study measuring ANGPTL-4 before and after BMI-loss. In the cross-sectional study, circulating ANGPTL-4 levels were lower in children with obesity than in those with normal weight. Moreover, ANGPTL-4 presented a negative correlation with BMI, waist circumference, weight, insulin, homeostasis model assessment of insulin resistance index (HOMA index), triglycerides, and leptin, and a positive correlation with FFA and vitamin-D. In the longitudinal study, the percent change in plasma ANGPTL-4 was correlated with the percent change in FFA, total-cholesterol and high-density lipoprotein cholesterol. This study reveals a significant association of ANGPTL-4 with pediatric obesity and plasma lipid profile

Noncollinear magnetic ordering in small Chromium Clusters

We investigate noncollinear effects in antiferromagnetically coupled clusters using the general, rotationally invariant form of local spin-density theory. The coupling to the electronic degrees of freedom is treated with relativistic non-local pseudopotentials and the ionic structure is optimized by Monte-Carlo techniques. We find that small chromium clusters (N \le 13) strongly favor noncollinear configurations of their local magnetic moments due to frustration. This effect is associated with a significantly lower total magnetization of the noncollinear ground states, ameliorating the disagreement between Stern-Gerlach measurements and previous collinear calculations for Cr_{12} and Cr_{13}. Our results further suggest that the trend to noncollinear configurations might be a feature common to most antiferromagnetic clusters.Comment: 9 pages, RevTeX plus .eps/.ps figure

Direct-acting antivirals are effective and safe in HCV/HIV-coinfected liver transplant recipients who experience recurrence of hepatitis C: A prospective nationwide cohort study.

Direct-acting antivirals have proved to be highly efficacious and safe in monoinfected liver transplant (LT) recipients who experience recurrence of hepatitis C virus (HCV) infection. However, there is a lack of data on effectiveness and tolerability of these regimens in HCV/HIV-coinfected patients who experience recurrence of HCV infection after LT. In this prospective, multicenter cohort study, the outcomes of 47 HCV/HIV-coinfected LT patients who received DAA therapy (with or without ribavirin [RBV]) were compared with those of a matched cohort of 148 HCV-monoinfected LT recipients who received similar treatment. Baseline characteristics were similar in both groups. HCV/HIV-coinfected patients had a median (IQR) CD4 T-cell count of 366 (256-467) cells/µL. HIV-RNA was <50 copies/mL in 96% of patients. The DAA regimens administered were SOF + LDV ± RBV (34%), SOF + SMV ± RBV (31%), SOF + DCV ± RBV (27%), SMV + DCV ± RBV (5%), and 3D (3%), with no differences between the groups. Treatment was well tolerated in both groups. Rates of SVR (negative serum HCV-RNA at 12 weeks after the end of treatment) were high and similar for coinfected and monoinfected patients (95% and 94%, respectively; P = .239). Albeit not significant, a trend toward lower SVR rates among patients with advanced fibrosis (P = .093) and genotype 4 (P = .088) was observed. In conclusion, interferon-free regimens with DAAs for post-LT recurrence of HCV infection in HIV-infected individuals were highly effective and well tolerated, with results comparable to those of HCV-monoinfected patients

EVALUATION OF A SLAM-BASED POINT CLOUD FOR DEFLECTION ANALYSIS IN HISTORIC TIMBER FLOORS

This paper aims at evaluating the possibility of using wearable mobile mapping solutions as a tool for detecting deflections in timber floors. These construction systems are prone to present this type of damage due to the mechanical properties of the wood (relatively low flexural stiffness and creep behaviour). During this study we have evaluated the chance of introducing an additional stage to the general workflow. This stage is devoted to reduce the noise of the 3D point cloud by using the Statistical Outlier Removal filter in combination with a noise-reduction filter such as the Anisotropic filter, the PointCleannet or the Scored-based denoised networks (Deep Learning methods). According with our results, the use of this strategies improves the quality of the 3D point cloud form a qualitative and quantitative point of view. However, these improvements seem to be not sufficient for using this product as a universal source of information for deflection analysis. In this sense, and according with the sensor and study case exploited, this type of point clouds could be used in floors with 5-8-meter length and a relative deflection of about L/200 or higher

Medios de comunicación y derecho a la información en Jalisco 2013

En el primer apartado, dedicado al sistema de medios en general, se presentan tres artículos: “Nuevos medios de comunicación en Jalisco”, “c7 ¿medio público o vocero del gobierno?” y “Réquiem por un ombudsman”. El segundo apartado está dedicado al tema de la libertad de expresión; se presentan aquí dos textos: “La vulnerabilidad en un ambiente de cambio. Los ataques a los medios de comunicación en Jalisco durante el año” y “Violaciones a la libertad de expresión de periodistas y trabajadores de medios en Jalisco, 1995-2013”. En el apartado “Derecho a la información, comunicación y política” se ofrecen cuatro textos de índole muy diversa: “La estrategia de comunicación del Gobierno del Estado”, “Diálogos públicos: la discusión de una nueva ley de transparencia para Jalisco”, “Cuando un niño desaparece, el peor enemigo es el tiempo…”, sobre la alerta Amber, y “2013: un año marcado por despidos en diversos periódicos de Guadalajara”. En la sección “Los que se fueron” se presenta la semblanza de Felipe Vicencio. Y en el apartado de “La investigación del observatorio de medios” se comparten los resultados de un trabajo sobre los columnistas de opinión jaliscienses que escriben en la prensa local.ITESO, A.C