250 research outputs found
Numana and its ancient territory: new data and research perspectives
Numana is one of the most important centers for the Picenian civilization and prospered in the Marche and Abruzzo regions during the Iron Age. Almost all of the archaeological evidence found until now refers to the necropoleis spread over a broad territory, while data concerning inhabited areas are quite scarce. Although findings are plenty, the study of Ancient Numana is quite incomplete. As a matter of fact, all the published materials are related to single burials or finds and there are no overall studies on its territory. A recent research project involving a wider sector of the largest Numana necropolis (Quagliotti-Davanzali), has not been published yet but offers a detailed description since the excavation documentation is available. The project sets out to consider burials as organized systems, offering information on cultural transformations and on the social organization of the ancient community. The systematic analysis of the data from the burial and the single funerary sets - to be organized in a specific GIS - will be accompanied by an investigation of the ancient landscape in its many components - necropolis and inhabited area - in its diachronic development, thanks to the results of other recent analyses carried out in the Numana territory (geomorphology, GIS of the archaeological map, new surveys of the territory). The scope of the project is therefore to analyze times, ways of arrangements, shapes of the Ancient Numana, in its definition of a territorial, inhabited, rural space, by using methods and techniques to record and read new data, to build knowledge in a scenario which can be integrated with results coming from future research
Fast atom diffraction inside a molecular beam epitaxy chamber, a rich combination
Two aspects of the contribution of grazing incidence fast atom diffraction
(GIFAD) to molecular beam epitaxy (MBE) are reviewed here: the ability of GIFAD
to provide \emph{in-situ} a precise description of the atomic-scale surface
topology, and its ability to follow larger-scale changes in surface roughness
during layer-by-layer growth. Recent experimental and theoretical results
obtained for the He atom beam incident along the highly corrugated direction of the (24) reconstructed GaAs(001) surface are
summarized and complemented by the measurements and calculations for the beam
incidence along the weakly corrugated [010] direction where a periodicity twice
smaller as expected is observed. The combination of the experiment, quantum
scattering matrix calculations, and semiclassical analysis allows in this case
to reveal structural characteristics of the surface. For the in situ
measurements of GIFAD during molecular beam epitaxy of GaAs on GaAs surface we
analyse the change in elastic and inelastic contributions in the scattered
beam, and the variation of the diffraction pattern in polar angle scattering.
This analysis outlines the robustness, the simplicity and the richness of the
GIFAD as a technique to monitor the layer-by-layer epitaxial growth
An anomalous alloy: Y_x Si_{1-x}
We study via density functional-based molecular dynamics the structural and
dynamical properties of the rare earth silicon amorphous alloy Y_xSi_{1-x} for
x=0.093 and x=0.156. The Si network forms cavities in which a Y^{3+} cation is
entrapped. Its electrons are transferred to the Si network and are located in
the dangling bonds of the Si atoms that line the Y cavities. This leads to the
presence of low coordinated Si atoms that can be described as monovalent or
divalent anions. For x=0.156, the cavities touch each other and share Si atoms
that have two dangling bonds. The vibrational spectrum is similar to that of
amorphous Si. However, doping induces a shoulder at 70 cm^{-1} and a pronounced
peak at 180 cm^{-1} due to low coordinated Si.Comment: 4 pages, 4 figure
gp91phox-dependent expression of platelet CD40 ligand
Background-CD40 ligand (CD40L) expression on platelets is mediated by agonists, but the underlying mechanism is still unclear. Methods and Results-CD40L expression was measured in platelets from healthy subjects both with and without the addition of antioxidants or a phospholipase A2 (PLA2) inhibitor and in platelets from 2 patients with an inherited deficiency of gp91phox. Immunoprecipitation analysis was also performed to determine whether normal platelets showed gp91phox expression. Unlike catalase and mannitol, superoxide dismutase inhibited agonist-induced platelet CD40L expression in healthy subjects. Immunoprecipitation analysis also showed that platelets from healthy subjects expressed gp91phox. In 2 male patients with inherited gp91phox deficiency, collagen-, thrombin-, and arachidonic acid-stimulated platelets showed an almost complete absence of superoxide anion (O2-) and CD40L expression. Incubation of platelets from healthy subjects with a PLA2 inhibitor almost completely prevented agonist-induced O2- and CD40L expression. Conclusions-These data provide the first evidence that platelet CD40L expression occurs via arachidonic acid-mediated gp91phox activation
Shock-Wave Heating Model for Chondrule Formation: Prevention of Isotopic Fractionation
Chondrules are considered to have much information on dust particles and
processes in the solar nebula. It is naturally expected that protoplanetary
disks observed in present star forming regions have similar dust particles and
processes, so study of chondrule formation may provide us great information on
the formation of the planetary systems.
Evaporation during chondrule melting may have resulted in depletion of
volatile elements in chondrules. However, no evidence for a large degree of
heavy-isotope enrichment has been reported in chondrules. In order to meet this
observed constraint, the rapid heating rate at temperatures below the silicate
solidus is required to suppress the isotopic fractionation.
We have developed a new shock-wave heating model taking into account the
radiative transfer of the dust thermal continuum emission and the line emission
of gas molecules and calculated the thermal history of chondrules. We have
found that optically-thin shock waves for the thermal continuum emission from
dust particles can meet the rapid heating constraint, because the dust thermal
emission does not keep the dust particles high temperature for a long time in
the pre-shock region and dust particles are abruptly heated by the gas drag
heating in the post-shock region. We have also derived the upper limit of
optical depth of the pre-shock region using the radiative diffusion
approximation, above which the rapid heating constraint is not satisfied. It is
about 1 - 10.Comment: 58 pages, including 5 tables and 15 figures, accepted for publication
in The Astrophysical Journa
Consanguinity and polygenic diseases: a model for antibody deficiencies
Primary immunodeficiencies represent a heterogeneous group of disorders of the immune system, predisposing to various types of infections. Among them, common variable immunodeficiency is the most common symptomatic antibody deficiency. It includes several different forms characterized by defects in the terminal stage of B lymphocyte differentiation, leading to markedly reduced immunoglobulin serum levels and increased susceptibility to bacterial infections. The clinical phenotype is complex, including autoimmunity, granulomatous inflammation, lymphoproliferative disorders and malignancies. Rare autosomal recessive mutations in a number of single genes have recently been reported. However, the underlying genetic defects remain unknown in the majority of cases. In order to seek new genes responsible for the disease, we studied a consanguineous Italian family through exome sequencing combined with homozygosity mapping. Six missense homozygous variants passed our filtering selection and at least two of them were associated with some aspects of the pathological phenotype. Our data remark the complexity of immune system disorders and emphasize the difficulty to understand the significance of genetic results and their correlation with the disease phenotype
Atomic Diagnostics of X-ray Irradiated Protoplanetary Disks
We study atomic line diagnostics of the inner regions of protoplanetary disks
with our model of X-ray irradiated disk atmospheres which was previously used
to predict observable levels of the NeII and NeIII fine-structure transitions
at 12.81 and 15.55mum. We extend the X-ray ionization theory to sulfur and
calculate the fraction of sulfur in S, S+, S2+ and sulfur molecules. For the
D'Alessio generic T Tauri star disk, we find that the SI fine-structure line at
25.55mum is below the detection level of the Spitzer Infrared Spectrometer
(IRS), in large part due to X-ray ionization of atomic S at the top of the
atmosphere and to its incorporation into molecules close to the mid-plane. We
predict that observable fluxes of the SII 6718/6732AA forbidden transitions are
produced in the upper atmosphere at somewhat shallower depths and smaller radii
than the neon fine-structure lines. This and other forbidden line transitions,
such as the OI 6300/6363AA and the CI 9826/9852AA lines, serve as complementary
diagnostics of X-ray irradiated disk atmospheres. We have also analyzed the
potential role of the low-excitation fine-structure lines of CI, CII, and OI,
which should be observable by SOFIA and Herschel.Comment: Accepted by Ap
Inherited human gp91phox deficiency is associated with impaired isoprostane formation and platelet dysfunction
Platelet isoprostane 8-ISO-prostaglandin F2α (8-iso-PGF2α), a proaggregating molecule, is believed to derive from nonenzymatic oxidation of arachidonic acid. We hypothesized that NADPH is implicated in isoprostane formation and platelet activation
Noncanonical Fungal Autophagy Inhibits Inflammation in Response to IFN-γ via DAPK1
Defects in a form of noncanonical autophagy, known as LC3-associated phagocytosis (LAP), lead to increased inflammatory pathology during fungal infection. Although LAP contributes to fungal degradation, the molecular mechanisms underlying LAP-mediated modulation of inflammation are unknown. We describe a mechanism by which inflammation is regulated during LAP through the death-associated protein kinase 1 (DAPK1). The ATF6/C/EBP-β/DAPK1 axis activated by IFN-γ not only mediates LAP to Aspergillus fumigatus but also concomitantly inhibits Nod-like receptor protein 3 (NLRP3) activation and restrains pathogenic inflammation. In mouse models and patient samples of chronic granulomatous disease, which exhibit defective autophagy and increased inflammasome activity, IFN-γ restores reduced DAPK1 activity and dampens fungal growth. Additionally, in a cohort of hematopoietic stem cell-transplanted patients, a genetic DAPK1 deficiency is associated with increased inflammation and heightened aspergillosis susceptibility. Thus, DAPK1 is a potential drugable player in regulating the inflammatory response during fungal clearance initiated by IFN-γ
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