Aerobic exercise training as a potential source of natural antibodies protective against human immunodeficiency virus-1

Despite the effectiveness of HAART in controlling HIV-1 replication, the emergence of drug-resistant viruses in infected patients and the severe side effects caused by the currently used drug regimens and the lack of an effective vaccine necessitate the continued search for new therapeutic strategies for prevention and therapy of HIV disease. Previously we reported that natural autoantibodies, recognizing peptide FTDNAKTI (peptide NTM1) derived from the C2 domain of HIV-1 gp120, contribute to the control of HIV disease. Here we demonstrated that sera from well-trained athletic (HIV-negative) subjects showed high reactivity with peptide NTM1. This result confirms that aerobic exercise training stimulates production of natural autoantibodies, which recognize peptide NTM1. Bioinformatics analysis indicates that these natural autoantibodies could slow down disease progression by blocking the superantigenic site on HIV-1 gp120. The results suggest that aerobic exercise training may be a promising non-toxic and inexpensive adjunctive anti-HIV therapy

Anthropometric characteristics and physiological responses of high level swimmers and performance in 100 m freestyle swimming

The effect of the anthropometric characteristics on performances has been the subject of many studies (Reilly, T., Bangsbo, J., & Franks, A. (2000). Anthropometric and physiological predispositions for elite soccer. Journal of Sports Science, 18(9), 669–683) but performance also depends on different physiological parameters. The aim of the present study is to define the anthropometric and physiological variables that best predict performance time of 100 m freestyle swimming. Twenty-five competitive male swimmers (age: 15 ± 1.2 years) participated in the research. Multiple stepwise regression analysis showed that arm span is the best predictor of 100 m freestyle swimming performance (r = 0.835). Arm span explains 68.5% of the variance of dependent variable (Adj R2: 0.685). In the final model, the variables that best describe 100 m freestyle swimming are the number of strokes of 100 m freestyle swimming, triceps skinfold, pelvis and shoulders width (Adj R2: 0.882). These findings confirm the importance of the anthropometric variables for swimming performance and could help coaches in the selection of high-level athletes

Can natural antibodies to VIP or VIP-like HIV-1 glycoprotein facilitate prevention and supportive treatment of breast cancer?

Objectives: The incidence of non-AIDS-defining cancer is remarkably higher in HIV-infected than in the general population. In contrast, breast cancer risk is significantly reduced in the HIV-infected population. The molecular mechanisms underlying the phenomenon of suppression of breast cancer in the HIV-infected population may serve as a basis for development of a new platform for prevention and treatment of breast cancer. Hypothesis: Various evidences indicate that vasoactive intestinal peptide (VIP) plays an important role in growth, and differentiation of breast cancer. We previously showed (i) that natural antibodies recognizing VIP and the gp120-derived peptide NTM significantly contribute to the control of HIV disease progression by suppression of VIP-like activity of HIV-1 gp120 and (ii) that physical exercise stimulates production of these natural antibodies. These findings suggest that natural anti-VIP/NTM antibodies could contribute to a decrease of breast cancer in the HIV-infected population by suppression of VIP, which may play a pro/oncogenic function. Aerobic exercise which stimulates production of anti-VIP/NTM antibodies could be used as prevention and supportive treatment of breast cancer. Impact: Immunotherapy based on natural anti-VIP/NTM antibodies could serve as an effective adjunct therapy for the treatment of breast cancer. Similarly, aerobic exercise, which stimulates production of these antibodies, should be considered as an inexpensive and safe preventive and supportive breast cancer therapy. Natural anti-VIP/NTM antibodies also represent promising prognostic marker for breast cancer. (C) 2011 Elsevier Ltd. All rights reserved

Differences in the efficiency between the grab and track starts for both genders in Greek young swimmers

The aim of this study was to determine the differences in the kinematic parameters between the grab and track starts and the differences in these two starts between genders. A total of 27 swimmers at the competitive level participated in the study, 13 boys (mean ± SD: age 15.8 ± 0.8 years, body mass 67.7 ± 7.7 kg and body height 178.6 ± 5.7 cm) and 14 girls (mean ± SD: age 16 ± 0.8 years, body mass 59.2 ± 6.6 kg and body height 166.2 ± 6.7 cm). Each swimmer performed three attempts for both start techniques. The best attempt of the grab start and the track start was taken for further analysis. The following kinematic parameters were analysed: flight distance, flight time, flight velocity, entry angle and reaction time. The males had greater numeric values for the results in all kinematic parameters for the grab start compared with the track start, except for flight velocity and entry angle (flight time 0.42 vs. 0.41 s, flight distance 3.21 vs. 3.14 m, flight velocity 7.76 vs. 7.83 m/s, entry angle 44.22 vs. 43.85 degrees and reaction time 0.86 vs. 0.81 s). The females also had greater numeric values for the results in all kinematic parameters for the grab start compared with the track start, except for flight time (flight time 0.38 vs. 0.38 s, flight distance 2.82 vs. 2.73 m, flight velocity 7.47 vs. 7.31 m/s, entry angle 45.18 vs. 44.79 degrees and reaction time 0.88 vs. 0.82 s). These results indicate that the males had significantly better results for flight time and flight distance compared with the females for the grab start (flight time 0.42 vs. 0.38 s, flight distance 3.21 vs. 2.82 m). In the case of the track start, the males had significantly better results for flight distance (3.14 vs. 2.73 m). Exploring the characteristics of the two starts did not lead to any significant kinematic differences. Therefore, a conclusion that demonstrates the superiority of one of the techniques cannot be reached. The coach, together with each swimmer individually, should devote some time to decide after some tests what type of start is better for the body type and general qualifications of the swimmer

Could depression be a new branch of MIA syndrome?

The aims of the present study were to determine the prevalence of depression in our dialysis patients, to detect the most powerful variables associated with depression, and to determine the role of depression in prediction of mortality. The prospective follow-up study of 128 patients (77 HD and 51 CAPD, 65 male, aged 53.8 +/- 13.5 years, dialysis duration 64.7 +/- 64.8 months) was carried out over 3 6 months. Depression by the Beck Depression Inventory-BDI-II score, laboratory parameters (hemoglobin, serum albumin and creatinine concentration), immunological status (cytokines and hsCRP), comorbidity by Index of Physical Impairment (IPI) and adequacy of dialysis by Kt/V were monitored. The overall prevalence of depression in the dialysis patients (BDI score >= 14) was 45.3%, and 28.2%, respectively, for moderate and severe depression (BDI >= 20). The most powerful variable associated with depression was IL-6, but associations with albumin, hemoglobin, creatinine and IPI score were also found. During the follow-up period 36 patients died, 7 patients left the cohort and 2 patients were transplanted. If IPI score was not included in the multivariate Cox analysis, the BDI score remained one of the best predictors of mortality along with albumin. In conclusion, because of the close association of depression with inflammation, malnutrition, and cardiovascular mortality, it could be speculated that depression is one branch of the MIA (malnutrition, inflammation, atherosclerosis) syndrome

Lipid peroxidation as risk factor for endothelial dysfunction in antiphospholipid syndrome patients

The aim of this study was to evaluate oxidative stress markers and it relations to endothelial damage as risk factor for thrombosis in patients with primary (PAPS) and secondary (SAPS) antiphospholipid syndrome (APS) in correlation to traditional risk factors. Flow-mediated (FMD) and nitroglycerine (NMD)-induced dilation of the brachial artery were studied in 140 APS patients (90 PAPS, 50 SAPS) and 40 controls matched by age, sex, and conventional risk factors for atherosclerosis. Markers of oxidative stress, lipid hydroperoxydes (LOOH), advanced oxidation protein products (AOPP), total sulfhydryl groups (tSHG), and paraoxonase 1 activity (PON1) were determined by spectrophotometric method. Oxidative stress dominates in APS patients. LOOH and AOPP correlate to lipid fractions (p lt 0.05), unlike PON1, tSHG that correlated to antiphospholipid antibody positivity (p lt 0.05). FMD was lower in APS patients comparing to controls (p lt 0.001). Cholesterol is independent variable for FMD impairment in control group (p = 0.011); LOOH in PAPS (p = 0.004); LOOH, aCL, and triglycerides in SAPS patients (p = 0.009, p = 0.049, and p = 0.012, respectively). Combined predictive of aCL and LOOH is better for FMD impairment than LOOH alone in both PAPS and SAPS patients (AUC 0.727, p = 0.001, 95 % CI 0.616-0.837 and AUC 0.824, pE,0.001, 95 % CI 0.690-0.957, respectively). Lipid peroxidation is independent predictor for endothelial dysfunction in APS patients. We demonstrated synergistic effect of aCL and LOOH as risk for endothelial impairment in both PAPS and SAPS patients