45 research outputs found
33 RENO: A European surveillance registry of coronary brachytherapy with the NovosteTM Beta-CathTM System
Full text linkWorth to Share? How Content Characteristics and Article Competitiveness Influence News Sharing on Social Network Sites
No full textDoes communication studies have an identity? Setting the bases for contemporary research
No full textPsychological predictors of political Internet use and political knowledge in light of the perceived complexity of political issues
No full text
Highly Regioselective Protecting-Group-Free Synthesis of the Antimalarial Drug MMV693183
No full textMMV693183 is a promising
antimalarial drug candidate that works
for uncomplicated malaria treatment and resistance management. Herein,
we report an efficient and highly regioselective synthesis of MMV693183.
This novel synthetic method highlights a three-step route with an
overall yield of 46% from readily available starting materials. The
key to the success lies in (1) utilizing the subtle difference of
the two amino groups in the starting material (S)-propane-1,2-diamine
dihydrochloride without amino protection and (2) identifying the L-(+)-tartaric acid as the counter acid for the organic
salt formation, yielding the desired regioisomer up to 100:0. The
efficient and scalable three-step protocol operates under mild conditions
with a high chemo/regioselectivity, providing effective access to
MMV693183
