p-Adic and Adelic Harmonic Oscillator with Time-Dependent Frequency

The classical and quantum formalism for a p-adic and adelic harmonic oscillator with time-dependent frequency is developed, and general formulae for main theoretical quantities are obtained. In particular, the p-adic propagator is calculated, and the existence of a simple vacuum state as well as adelic quantum dynamics is shown. Space discreteness and p-adic quantum-mechanical phase are noted.Comment: 10 page

Impact of genetics on neoadjuvant therapy with complete pathological response in metastatic colorectal cancer: case report and review of the literature

Treatment of colorectal metastatic cancer is still challenging, despite recent improvements in chemotherapy. A genetic cancer profile, such as the KRAS (Kirsten rat sarcoma) gene status, plays a key role in individualized tailored therapy. Molecular targeted therapy added to neoadjuvant chemotherapy can achieve a better pathological response and prolong survival. Pathological complete response of colorectal cancer stage N is rare. A 47-year-old female patient presented with rectal adenocarcinoma and three liver metastases (cT3d/4, N2, M1). After seven cycles of Bevacizumab and CAPOX in neoadjuvant setting, we noted more than 70.0% regression of metastases and complete regression of the primary tumor. We performed low anterior resection of rectum and synchronous subsegmental resection of S3, because the other two lesions were not detectable. Pathology revealed complete response of the primary and also secondary tumors. After 8 months, diagnostic tests did not show any sign of recurrence and the remaining liver lesions disappeared. Colorectal cancer is a heterogeneous disease and it is necessary to identify patients who are at-risk of recurrence and suitable for neoadjuvant therapy. Genetic biomarkers play an important role in metastatic colorectal cancer treatment. Because of the mutated KRAS gene, Bevacizumab was added to cytotoxic therapy achieving a complete pathological response of primary tumor and metastasis. This case is unique because all reported cases with similar results, described staged surgery and one of reverse staged surgery, but with similar results. This neoadjuvant therapy has extra ordinary results for colorectal cancer stage IV and can help disease-free and long-term survival

Uticaj mikrobiološkog đubriva i oplemenjivača zemljišta na prinos heljde (Fagopyrum esculentum Moench) u uslovima veće nadmorske visine

Effect of microbiological fertilizer (Slavol) and soil additives (zeolite and hydrogel) on buckwheat (Fagopyrum esculentum Moench) yield was investigated in this paper. Trial was set up in the village of Radijevići, Serbia in agroecological conditions of mountain Zlatar (altitude 1,065 m) during a two-year period 2009 and 2010. A randomized complete block design with four replications was set up. In organic cropping system three combinations of microbiological fertilizer (Slavol) with zeolite and hydrogel were used prior to sowing. Different combinations of the microbiological fertilizer and the soil additives gave positive results especially in the second year of the trial. The best combination in organic cropping system was Slavol+hydrogel with foliar application of the microbiological fertilizer, which resulted in the greatest yield of buckwheat and this treatment can be recommended to producers. Buckwheat performed very well under limited conditions of acidic soil on high altitude in organic cropping system and it can be recommended as a very suitable crop for organic producers.U ovom radu je ispitivan uticaj mikrobiološkog đubriva (Slavol) i oplemenjivača zemljišta (zeolita i hidrogela) na prinos heljde (Fagopyrum esculentum Moench). Ogled je postavljen u selu Radijevići u agroekološkim uslovima planine Zlatar na nadmorskoj visini od 1.065 m tokom dvogodišnjeg perioda 2009. i 2010. Ogled je postavljen po slučajnom blok sistemu u četiri ponavljanja. U organskom sistemu gajenja su primenjene tri kombinacije mikrobiološkog đubriva sa zeolitom i hidrogelom pre setve useva. Sve varijante đubrenja su dale pozitivne rezultate u odnosu na prinos, naročito u drugoj godini istraživanja. Najbolja kombinacija u organskom sistemu gajenja je bila varijanta Slavol+hydrogel sa folijarnom primenom mikrobiološkog đubriva Slavola, koja je dala i najveći prinos heljde. Gajenje heljde pod limitiranim uslovima kiselog zemljišta na većoj nadmorskoj visini u organskom sistemu gajenja se pokazalo opravdanim i može se preporučiti proizvođačima

On p-Adic Sector of Adelic String

We consider construction of Lagrangians which are candidates for p-adic sector of an adelic open scalar string. Such Lagrangians have their origin in Lagrangian for a single p-adic string and contain the Riemann zeta function with the d'Alembertian in its argument. In particular, we present a new Lagrangian obtained by an additive approach which takes into account all p-adic Lagrangians. The very attractive feature of this new Lagrangian is that it is an analytic function of the d'Alembertian. Investigation of the field theory with Riemann zeta function is interesting in itself as well.Comment: 10 pages. Presented at the 2nd Conf. on SFT and Related Topics, Moscow, April 2009. Submitted to Theor. Math. Phy

Varijabilnost i koeficijent heritabilnosti prosečnog sadržaja suve materije u lukovicama crnog luka (Allium cepa L.)

In order to research the variability of average dry matter content in onion bulbs, the trial has been set up on the experimental plot in the Centre for Vegetable Crops in Smederevska Palanka during 2000. and 2001. The trial has been performed by applying the method of random block design with five replicas. Ten cultivars of different geographical origin have been used. Examined characteristics were determined by applying the variance analysis of two-factorial trial - model 2. Hadzivukovic, 1991. The components of phenotype variance, genotype and phenotype coefficient of variance and heritability in broader sense have been calculated according to SINGH and CHAUDHARY (1976). The significant variability has been found for dry matter content in bulbs during both years of research. The researched trait had a greater genotype variance than out door conditions factor variance and the coefficient of phenotype variation greater than genetic variance coefficient. High percentage of genetic variability in total phenotype variability has been confirmed by high heritability. .U cilju ispitivanja varijabilnosti prosečnog sadržaja suve materije u lukovicama crnog luka, postavljen je ogled na oglednom polju Centra za povrtarstvo u Smederevskoj Palanci u toku 2000. i 2001. godine. Ogled je izveden po slučajnom blok sistemu u pet ponavljanja. Za istraživački materijal korišćeno je deset sorata, različitog geografskog porekla. Utvrđene vrednosti ispitivanih svojstava su obrađene analizom varijanse dvofaktorijalnog ogleda-model 2. (Hadživuković, 1991). Komponente fenotipske varijanse, genotipski i fenotipski koeficijent varijacije i heritabilnost u širem smislu izračunate su prema Singh i Chaudhary (1976). Značajna varijabilnost je dobijena za prosečni sadržaj suve materije u lukovicama tokom obe godine istraživanja. Ispitivana osobina imala je varijansu genotipa veću od varijanse faktora spoljašnje sredine i koeficijent fenotipske varijacije veći od koeficijenta genetičke varijacije. Veći udeo genetičke u ukupnoj fenotipskoj varijabilnosti potvrđuje visoka heritabilnost.

Agriotypus armatus Curtis, 1832, a parasitoid of Silo pallipes Fabricius, 1781: the first record for the Balkan Peninsula

Among the diverse order of Hymenoptera, aquatic species are of special interest. During macrozoobenthos sampling in the rivers of Serbia in 2003 and during the period 2011-2012, pupae of Silo pallipes Fabricius, 1781 were recorded which were parasitized by an ichneumonid wasp Agriotypus armatus Curtis, 1832, this being the first record of it for the Balkan Peninsula. A total of 217 A. armatus specimens were collected at 29 localities situated along 16 watercourses of Serbia. All four parasitoid stages (egg, larva, pupa and resting adult) were recorded. The identity of the parasitoid was confirmed using standard molecular methods. This study also focuses on the ecology of the parasitoid and its host. The widespread distribution of A. armatus in Europe suggests the presence of this species in other Balkan countries, but this has not yet been confirmed due to a lack of surveys and/or the constantly increasing pollution of freshwaters

The influence of temperature on mechanical properties of the base material (BM) and welded joint (WJ) made of steel S690QL

This paper presents the analysis of the influence of temperature on mechanic properties of the base material and welded joints made of high strength steel. The joints were welded on S690QL high strength steel plates using the Metal Active Gas (MAG) Welding and two filler materials of different properties. Since the steel S690QL belongs to a group of steels with high strength, the aim of this paper is to determine the temperature at which strength starts to decrease. Experimental tensile testings of the welded joints were performed at five different temperatures in the range from 20 to 550 °C

Selection of the optimal hard facing (HF) technology of damaged forging dies based on cooling time t8/5

In exploitation, the forging dies are exposed to heating up to very high temperatures, variable loads: compressive, impact and shear. In this paper, the reparatory hard facing of the damaged forging dies is considered. The objective was to establish the optimal reparatory technology based on cooling time t8/5 . The verification of the adopted technology was done by investigation of the hard faced layers microstructure and measurements of hardness within the welded layers’ characteristic zones. Cooling time was determined theoretically, numerically and experimentally

The influence of temperature on mechanical properties of the base material (BM) and welded joint (WJ) made of steel S690QL

This paper presents the analysis of the influence of temperature on mechanic properties of the base material and welded joints made of high strength steel. The joints were welded on S690QL high strength steel plates using the Metal Active Gas (MAG) Welding and two filler materials of different properties. Since the steel S690QL belongs to a group of steels with high strength, the aim of this paper is to determine the temperature at which strength starts to decrease. Experimental tensile testings of the welded joints were performed at five different temperatures in the range from 20 to 550 °C