Environmental Impact on Vascular Development Predicted by High-Throughput Screening

Background: Understanding health risks to embryonic development from exposure to environmental chemicals is a significant challenge given the diverse chemical landscape and paucity of data for most of these compounds. High-throughput screening (HTS) in the U.S. Environmental Protection Agency (EPA) ToxCast™ project provides vast data on an expanding chemical library currently consisting of > 1,000 unique compounds across > 500 in vitro assays in phase I (complete) and Phase II (under way). This public data set can be used to evaluate concentration-dependent effects on many diverse biological targets and build predictive models of prototypical toxicity pathways that can aid decision making for assessments of human developmental health and disease

The Shaman and the Spirits: The Meaning of the Word 'ling' in the Jiuge Poems

In all major dictionaries the first entry for the Chinese word 'ling' is 'shaman' (wu). This meaning of the word is based on Wang Yi's interpretation of two Jiuge poems in the Chuci collection. The present article investigates the possibility of this identification and concludes that there is no evidence to support Wang Yi's opinion. On the other hand, there is ample evidence to suggest that the accepted meanings of ling (spirit, numinous, magical) and the general characteristics of the Chinese shaman are indeed interrelated in many respects