Thermal log analysis for recognition of ground surface temperature change and water movements

International audienceA joint analysis of surface air temperature series recorded at meteorological stations and temperature-depth profiles logged in near-by boreholes was performed to estimate conditions existing prior to the beginning of the instrumental record in central-northern Italy. The adopted method considers conductive and advective heat transport in a horizontally layered medium and provides simultaneous estimates of the pre-observational temperatures and the Darcy velocities. The reconstruction of the ground surface temperature history using an inversion method was performed for boreholes where hydrological disturbances to measured temperature logs were proved to be negligible. Both methods revealed generally coherent climatic changes in the whole investigated area. Climatic conditions were generally warm and comparable with the reference period 1960?1990. The absence of the Little Ice Age in the middle ages seems to be a generic feature of the climate in central-northern Italy. Climate change of the 19th century was generally insignificant with well balanced periods of cold and warmth. The investigated area became significantly colder only at the end of the 19th century. Cooling culminated around 1950 when it was replaced by rapid warming. Recent warming was not inferred only for one of the investigated holes. This discrepancy can be attributed to local environmental conditions

Development status of the LAUE project

We present the status of LAUE, a project supported by the Italian Space Agency (ASI), and devoted to develop Laue lenses with long focal length (up to 100 meters), for hard X--/soft gamma--ray astronomy (80-600 keV). Thanks to their focusing capability, the design goal is to improve the sensitivity of the current instrumention in the above energy band by 2 orders of magnitude, down to a few times $10^{-8}$ photons/(cm$^2$ s keV).Comment: 9 pages, 9 figures, presented at the Space Telescopes and Instrumentation Symposium in Amsterdam, 2012: Ultraviolet to Gamma Ray Conference. Published in the Proceedings of the SPIE, Volume 8443, id. 84430B-84430B-9 (2012

New results on focusing of gamma-rays with Laue lenses

We report on new results on the development activity of broad band Laue lenses for hard X-/gamma-ray astronomy (70/100-600 keV). After the development of a first prototype, whose performance was presented at the SPIE conference on Astronomical Telescopes held last year in Marseille (Frontera et al. 2008), we have improved the lens assembling technology. We present the development status of the new lens prototype that is on the way to be assembled.Comment: 8 pages, 11 figures, to be Published in SPIE Proceedings, vol.7437-19, 200

A Cylindrical GEM Inner Tracker for the BESIII experiment at IHEP

The Beijing Electron Spectrometer III (BESIII) is a multipurpose detector that collects data provided by the collision in the Beijing Electron Positron Collider II (BEPCII), hosted at the Institute of High Energy Physics of Beijing. Since the beginning of its operation, BESIII has collected the world largest sample of J/{\psi} and {\psi}(2s). Due to the increase of the luminosity up to its nominal value of 10^33 cm-2 s-1 and aging effect, the MDC decreases its efficiency in the first layers up to 35% with respect to the value in 2014. Since BESIII has to take data up to 2022 with the chance to continue up to 2027, the Italian collaboration proposed to replace the inner part of the MDC with three independent layers of Cylindrical triple-GEM (CGEM). The CGEM-IT project will deploy several new features and innovation with respect the other current GEM based detector: the {\mu}TPC and analog readout, with time and charge measurements will allow to reach the 130 {\mu}m spatial resolution in 1 T magnetic field requested by the BESIII collaboration. In this proceeding, an update of the status of the project will be presented, with a particular focus on the results with planar and cylindrical prototypes with test beams data. These results are beyond the state of the art for GEM technology in magnetic field

Status of the array control and data acquisition system for the Cherenkov Telescope Array

The Cherenkov Telescope Array (CTA) will be the next-generation ground-based observatory using the atmospheric Cherenkov technique. The CTA instrument will allow researchers to explore the gamma-ray sky in the energy range from 20 GeV to 300 TeV. CTA will comprise two arrays of telescopes, one with about 100 telescopes in the Southern hemisphere and another smaller array of telescopes in the North. CTA poses novel challenges in the field of ground-based Cherenkov astronomy, due to the demands of operating an observatory composed of a large and distributed system with the needed robustness and reliability that characterize an observatory. The array control and data acquisition system of CTA (ACTL) provides the means to control, readout and monitor the telescopes and equipment of the CTA arrays. The ACTL system must be flexible and reliable enough to permit the simultaneous and automatic control of multiple sub-arrays of telescopes with a minimum effort of the personnel on-site. In addition, the system must be able to react to external factors such as changing weather conditions and loss of telescopes and, on short timescales, to incoming scientific alerts from time-critical transient phenomena. The ACTL system provides the means to time-stamp, readout, filter and store the scientific data at aggregated rates of a few GB/s. Monitoring information from tens of thousands of hardware elements need to be channeled to high performance database systems and will be used to identify potential problems in the instrumentation. This contribution provides an overview of the ACTL system and a status report of the ACTL project within CTA

Down-regulation of HSP70 sensitizes gastric epithelial cells to apoptosis and growth retardation triggered by H. pylori

<p>Abstract</p> <p>Background</p> <p><it>H. pylori </it>infection significantly attenuated the expression of HSP70 in gastric mucosal cells. However, the role of HSP70 cancellation in <it>H. pylori</it>-associated cell damages is largely unclear.</p> <p>Methods</p> <p>Small interfering RNA (siRNA) was used to down-regulate HSP70 in gastric epithelial cell lines AGS. The transfected cells were then incubated with <it>H. pylori </it>and the functions of HSP70 suppression were observed by viability assay, cell cycle analyses and TUNEL assay. HSP70 target apoptotic proteins were further identified by Western blot.</p> <p>Results</p> <p>The inhibition of HSP70 has further increased the effect of growth arrest and apoptosis activation triggered by <it>H. pylori </it>in gastric epithelial cells. The anti-proliferation function of HSP70 depletion was at least by up-regulating p21 and cell cycle modulation with S-phase accumulation. An increase of apoptosis-inducing factor (AIF) and cytosolic cytochrome C contributes to the activation of apoptosis following down-regulation of intracellular HSP70. Extracellular HSP70 increased cellular resistance to apoptosis by suppression the release of AIF and cytochrome c from mitochondria, as well as inhibition of p21 expression.</p> <p>Conclusions</p> <p>The inhibition of HSP70 aggravated gastric cellular damages induced by <it>H. pylori</it>. Induction of HSP70 could be a potential therapeutic target for protection gastric mucosa from <it>H. pylori</it>-associated injury.</p

Out-of-Plane Testing of Masonry Walls Retrofitted with Oriented Strand Board Timber Panels

Several studies on different techniques can be found on retrofitting existing unreinforced masonry (URM) walls using varieties of materials ranging from reinforced plaster, grout and epoxy injection to fibre-reinforced polymers. Still, there is a significant lack of experimental data that consider using a material such as oriented strand board (OSB) timber panels, which can be easily sourced around the globe, and are considered to be economical and sustainable. Hence, this paper presents the first stage of a multi-phase experimental investigation into the possibility of retrofitting URM walls using OSB panels. An experimental programme with full-scale testing is expensive, therefore small-scale testing such as the approach presented here is ideal to provide insight when proposing a new retrofit technique. In this paper, flexural strength in the form of four-point bending tests has been obtained on three plain masonry prisms and six OSB retrofitted specimens (615 × 215 × 102.5 mm). The effectiveness of the proposed OSB panel retrofit techniques has been assessed in terms of flexural strength, out-of-plane load capacity and displacement. It was observed that the application of the OSB panel at the back of a masonry prism greatly influenced the out-of-plane behaviour of the retrofitted specimen by increasing its flexural capacity and also by preventing its quasi-brittle collapse