2,346 research outputs found
Electron bombardment propulsion system characteristics for large space systems
The results of an anlaysis of electron bombardment ion propulsion systems for use in the transportation and on-orbit operations of large space systems are presented. Using baseline technology from the ongoing primary propulsion program and other sources, preliminary estimates of the expected characteristics of key system elements such as thrusters and propellant storage systems were performed. Projections of expected thruster performance on argon are presented based on identified constraints which limit the achievable thrust and/or power density of bombardment thrusters. System characteristics are then evaluated as a function of thruster diameter and specific impulse
Amino acid racemization reveals differential protein turnover in osteoarthritic articular and meniscal cartilages
INTRODUCTION: Certain amino acids within proteins have been reported to change from the L form to the D form over time. This process is known as racemization and is most likely to occur in long-lived low-turnover tissues such as normal cartilage. We hypothesized that diseased tissue, as found in an osteoarthritic (OA) joint, would have increased turnover reflected by a decrease in the racemized amino acid content. METHODS: Using high-performance liquid chromatography methods, we quantified the L and D forms of amino acids reported to racemize in vivo on a biological timescale: alanine, aspartate (Asp), asparagine (Asn), glutamate, glutamine, isoleucine, leucine (Leu), and serine (Ser). Furthermore, using a metabolically inactive control material (tooth dentin) and a control material with normal metabolism (normal articular cartilage), we developed an age adjustment in order to make inferences about the state of protein turnover in cartilage and meniscus. RESULTS: In the metabolically inactive control material (n = 25, ages 13 to 80 years) and the normal metabolizing control material (n = 19, ages 17 to 83 years), only Asp + Asn (Asx), Ser, and Leu showed a significant change (increase) in racemization with age (P < 0.01). The age-adjusted proportions of racemized to total amino acid (D/D+L expressed as a percentage of the control material) for Asx, Ser, and Leu when compared with the normal articular cartilage control were 97%, 74%, and 73% in OA meniscal cartilage and 97%, 70%, and 78% in OA articular cartilage. We also observed lower amino acid content in OA articular and meniscal cartilages compared with normal articular cartilage as well as a loss of total amino acids with age in the OA meniscal but not the OA articular cartilage. CONCLUSIONS: These data demonstrate comparable anabolic responses for non-lesioned OA articular cartilage and OA meniscal cartilage but an excess of catabolism over anabolism for the meniscal cartilage
Six solutions for more reliable infant research
Infant research is often underpowered, undermining the robustness and replicability of our findings. Improving the reliability of infant studies offers a solution for increasing statistical power independent of sample size. Here, we discuss two senses of the term reliability in the context of infant research: reliable (large) effects and reliable measures. We examine the circumstances under which effects are strongest and measures are most reliable and use synthetic datasets to illustrate the relationship between effect size, measurement reliability, and statistical power. We then present six concrete solutions for more reliable infant research: (a) routinely estimating and reporting the effect size and measurement reliability of infant tasks, (b) selecting the best measurement tool, (c) developing better infant paradigms, (d) collecting more data points per infant, (e) excluding unreliable data from the analysis, and (f) conducting more sophisticated data analyses. Deeper consideration of measurement in infant research will improve our ability to study infant development
Radiative decays of quarkonium states, momentum operator expansion and nilpotent operators
We present the method of calculation of radiative decays of composite
quark-antiquark systems with different J^{PC}: (Q\bar Q)_{in} -> gamma (Q\bar
Q)_{out}. The method is relativistic invariant, it is based on the double
dispersion relation integrals over the masses of composite mesons, it can be
used for the high spin particles and provides us with the gauge invariant
transition amplitudes. We apply this method to the case when the photon is
emitted by a constituent in the intermediate state (additive quark model). We
perform the momentum operator expansion of the spin amplitudes for the decay
processes. The problem of nilpotent spin operators is discussed.Comment: 21 pages, 1 figur
Reemergence of Policy Practice: A Journey Back to our Roots
Many people and events have contributed to a renewed focus on policy practice in social work and social work education, culminating in the inclusion of policy practice as one of the ten core social work competencies in the 2008 Council on Social Work Education EPAS. Robert Schneider, founder of Influencing State Policy, was a key player in elevating policy practice, particularly at the state level, in light of the increasing devolution of social policy decision-making to the states. Other social workers and educators created opportunities for policy scholars and practitioners to collaborate, including Leon Ginsberg and the Policy Conference that he and others initiated. Now a new generation of policy practitioners will continue to educate social workers in policy practice skills in the pursuit of social justic
Establishment of reference intervals for osteoarthritis related biomarkers – the FNIH/OARSI OA biomarkers consortium
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