ROLE OF TEST ABRASION IN THE DIAGNOSTICS AND TREATMENT OF FEMALE INFERTILITY

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SURGICAL TREATMENT OF SUPPURATIVE INFLAMMATION OF OVARIES

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Diagnostic and treatment strategy in complicated colon diverticulitis

Acute diverticulitis is a disease with a wide clinical spectrum, ranging from a phlegmon (stage I a) to localized abscesses (stages I b and II), to free perforation with purulent (stage III) or feculent (stage IV) peritonitis. The planned therapy of colonic diverticulitis is very difficult because preoperative diagnosis is uncommon and the method of treatment is usually decided at the time of laparotomy. While there is a little debate about the best treatment for mild episodes, uncertainty persists about the optimal management for severe episodes and complicated diverticulitis

Matching three-point functions of BMN operators at weak and strong coupling

The agreement between string theory and field theory is demonstrated in the leading order by providing the first calculation of the correlator of three two-impurity BMN states with all non-zero momenta. The calculation is performed in two completely independent ways: in field theory by using the large-$N$ perturbative expansion, up to the terms subleading in finite-size, and in string theory by using the Dobashi-Yoneya 3-string vertex in the leading order of the Penrose expansion. The two results come out to be completely identical.Comment: 14 pages, 1 figur

Holographic three-point functions of giant gravitons

Working within the AdS/CFT correspondence we calculate the three-point function of two giant gravitons and one pointlike graviton using methods of semiclassical string theory and considering both the case where the giant gravitons wrap an S^3 in S^5 and the case where the giant gravitons wrap an S^3 in AdS_5. We likewise calculate the correlation function in N=4 SYM using two Schur polynomials and a single trace chiral primary. We find that the gauge and string theory results have structural similarities but do not match perfectly, and interpret this in terms of the Schur polynomials' inability to interpolate between dual giant and pointlike gravitons.Comment: 21 page

On the pulsating strings in AdS_5 x T^{1,1}

We study the class of pulsating strings in AdS_5 x T^{1,1}. Using a generalized ansatz for pulsating string configurations we find new solutions of this class. Further we semiclassically quantize the theory and obtain the first correction to the energy. The latter, due to AdS/CFT correspondence, is supposed to give the anomalous dimensions of operators in the dual N=1 superconformal gauge field theory.Comment: 12 pages, improvements made, references adde

Wave functions and correlation functions for GKP strings from integrability

We develop a general method of computing the contribution of the vertex operators to the semi-classical correlation functions of heavy string states, based on the state-operator correspondence and the integrable structure of the system. Our method requires only the knowledge of the local behavior of the saddle point configuration around each vertex insertion point and can be applied to cases where the precise forms of the vertex operators are not known. As an important application, we compute the contributions of the vertex operators to the three-point functions of the large spin limit of the Gubser-Klebanov-Polyakov (GKP) strings in $AdS_3$ spacetime, left unevaluated in our previous work [arXiv:1110.3949] which initiated such a study. Combining with the finite part of the action already computed previously and with the newly evaluated divergent part of the action, we obtain finite three-point functions with the expected dependence of the target space boundary coordinates on the dilatation charge and the spin.Comment: 80 pages, 7 figures, v2: typos and minor errors corrected, a reference added, v3: typos and a reference corrected, published versio

Study of cosolvent-induced α-chymotrypsin fibrillogenesis: Does protein surface hydrophobicity trigger early stages of aggregation reaction?

The misfolding of specific proteins is often associated with their assembly into fibrillar aggregates, commonly termed amyloid fibrils. Despite the many efforts expended to characterize amyloid formation in vitro, there is no deep knowledge about the environment (in which aggregation occurs) as well as mechanism of this type of protein aggregation. Alpha-chymotrypsin was recently driven toward amyloid aggregation by the addition of intermediate concentrations of trifluoroethanol. In the present study, approaches such as turbidimetric, thermodynamic, intrinsic fluorescence and quenching studies as well as chemical modification have been successfully used to elucidate the underlying role of hydrophobic interactions (involved in early stages of amyloid formation) in α-chymotrypsin-based experimental system. © 2009 Springer Science+Business Media, LLC

The Contrasting Effect of Macromolecular Crowding on Amyloid Fibril Formation

Amyloid fibrils associated with neurodegenerative diseases can be considered biologically relevant failures of cellular quality control mechanisms. It is known that in vivo human Tau protein, human prion protein, and human copper, zinc superoxide dismutase (SOD1) have the tendency to form fibril deposits in a variety of tissues and they are associated with different neurodegenerative diseases, while rabbit prion protein and hen egg white lysozyme do not readily form fibrils and are unlikely to cause neurodegenerative diseases. In this study, we have investigated the contrasting effect of macromolecular crowding on fibril formation of different proteins.As revealed by assays based on thioflavin T binding and turbidity, human Tau fragments, when phosphorylated by glycogen synthase kinase-3β, do not form filaments in the absence of a crowding agent but do form fibrils in the presence of a crowding agent, and the presence of a strong crowding agent dramatically promotes amyloid fibril formation of human prion protein and its two pathogenic mutants E196K and D178N. Such an enhancing effect of macromolecular crowding on fibril formation is also observed for a pathological human SOD1 mutant A4V. On the other hand, rabbit prion protein and hen lysozyme do not form amyloid fibrils when a crowding agent at 300 g/l is used but do form fibrils in the absence of a crowding agent. Furthermore, aggregation of these two proteins is remarkably inhibited by Ficoll 70 and dextran 70 at 200 g/l.We suggest that proteins associated with neurodegenerative diseases are more likely to form amyloid fibrils under crowded conditions than in dilute solutions. By contrast, some of the proteins that are not neurodegenerative disease-associated are unlikely to misfold in crowded physiological environments. A possible explanation for the contrasting effect of macromolecular crowding on these two sets of proteins (amyloidogenic proteins and non-amyloidogenic proteins) has been proposed

Efficacy and timing of some new products against pear psylla (Cacopsylla pyri L.) (Hemiptera: Psyllidae): I. Spirotetramat

Abstract. Pear psylla (Cacopsylla pyri L.) (Hemiptera: Psyllidae) is one of the key insect pests in pear orchards of Bulgaria. Field trials to evaluate the efficacy and timing of spirotetramat (Movento 100 SC ®) against C. pyri were carried out in a commercial pear orchard in the village Dink near Plovdiv (Bulgaria) in 2014 and 2015. Three periods of application were tested against the second summer generation of C. pyri: (А) in the presence of predominantly "white" eggs, (B) in the presence of predominantly "yellow" eggs and the first hatched larvae, and (C) in the presence of about 15 – 30% hatched larvae and nymphs. In all three periods of application spirotetramat (Movento 100 SC) applied at a dose of 150 ml/hl effectively reduced the population of pear psylla after only once application. Movento 100 SC applied in the presence of predominantly "white" eggs (A) and in the presence of predominantly "yellow" eggs and the first hatched larvae (B) demonstrated better efficacy than in the presence of about 15 – 30% hatched larvae and nymphs (C). The efficacy of spirotetramat (Movento100 SC) in the first two periods of application (A) and (B) was similar and insignificantly different from that of the reference insecticide abamectin (Vertimec 18 EC, applied at a dose of 150 ml/hl), but significantly higher than the efficacy of spirotetramat, applied in period (C). The total reduction of larvae at three week post-treatment was at the level of 94.6 - 98.7% for the period (A) and (B), 89.7 – 93.3% for the period (C) and 94.0 – 98.7% for the reference insecticide - abamectin. The high efficacy observed in different terms of application and long persistence makes this product extremely valuable in controlling populations of C. pyri