La orgía: un acercamiento conceptual desde la teoría psicoanalítica

En una reunión que congrega a la clase prestante de una sociedad, y tras la intervención de un mago, se produce una orgía de la cual sólo una persona mantendrá intacto el recuerdo. Todo lo sucedido en el evento y después de él, es lo que narra el cuento “La Orgía” de Germán Espinosa, que fue el pretexto para analizar algunos conceptos del psicoanálisis freudiano relativos al inconsciente, la pulsión, la represión, la censura y la psicología de las masas. Este escrito, producto de la lectura y escritura colaborativa a lo largo de un semestre académico, da cuenta de lo elaborado en el marco de un grupo de estudio en psicoanálisis en el que participan egresados y estudiantes de psicología de todos los niveles de formación

Clonal chromosomal mosaicism and loss of chromosome Y in elderly men increase vulnerability for SARS-CoV-2

The pandemic caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2, COVID-19) had an estimated overall case fatality ratio of 1.38% (pre-vaccination), being 53% higher in males and increasing exponentially with age. Among 9578 individuals diagnosed with COVID-19 in the SCOURGE study, we found 133 cases (1.42%) with detectable clonal mosaicism for chromosome alterations (mCA) and 226 males (5.08%) with acquired loss of chromosome Y (LOY). Individuals with clonal mosaic events (mCA and/or LOY) showed a 54% increase in the risk of COVID-19 lethality. LOY is associated with transcriptomic biomarkers of immune dysfunction, pro-coagulation activity and cardiovascular risk. Interferon-induced genes involved in the initial immune response to SARS-CoV-2 are also down-regulated in LOY. Thus, mCA and LOY underlie at least part of the sex-biased severity and mortality of COVID-19 in aging patients. Given its potential therapeutic and prognostic relevance, evaluation of clonal mosaicism should be implemented as biomarker of COVID-19 severity in elderly people. Among 9578 individuals diagnosed with COVID-19 in the SCOURGE study, individuals with clonal mosaic events (clonal mosaicism for chromosome alterations and/or loss of chromosome Y) showed an increased risk of COVID-19 lethality