16 research outputs found
Los fantasmas en el teatro de Itziar Pascual : memoria y construcción identitaria
Este ensayo ofrece un análisis de los personajes fantasmales y las sombras que aparecen en varias obras de Itziar Pascual (Fuga, El domador de sombras, Blue Mountain, La paz del crepúsculo, Père Lachaise, Despedida, Mascando ortigas y Variaciones sobre Rosa Parks), en las que se observa la estrecha relación que guarda la introducción de espectros con la reivindicación de la memoria y la indagación en la identidad tanto individual como colectiva.This essay offers an analysis of the phantoms that appear in several plays by Itziar Pascual (Fuga, El domador de sombras, Blue Mountain, La paz del crepúsculo, Père Lachaise, Despedida, Mascando ortigas y Variaciones sobre Rosa Parks). There is a relationship between the presence of these spectral characters in theatre, the recovery of memory and the construction of personal and collective identity
Catalytic Enantioselective Allylic Amination of Unactivated Terminal Olefins via an Ene Reaction/[2,3]-Rearrangement
The enantioselective allylic amination of unactivated
terminal
olefins represents a direct and attractive strategy for the synthesis
of enantioenriched amines. We have developed the first use of a nitrogen-containing
reagent and a chiral palladium catalyst to convert unfunctionalized
olefins into enantioenriched allylic amines via an ene reaction/[2,3]-rearrangement
Synthesis of (±)-Amathaspiramide F and Discovery of an Unusual Stereocontrolling Element for the [2,3]-Stevens Rearrangement
A formal total synthesis of (±)-amathaspiramide F through a tandem palladium-catalyzed allylic amination/[2,3]-Stevens rearrangement is reported. The unexpected diastereoselectivity of the [2,3]-Stevens rearrangement was controlled by the substitution patterns of an aromatic ring. This discovery represents a new stereocontrolling element for [2,3]-sigmatropic rearrangements in complex molecular settings
Synthesis of (±)-Amathaspiramide F and Discovery of an Unusual Stereocontrolling Element for the [2,3]-Stevens Rearrangement
A formal total synthesis of (±)-amathaspiramide F through a tandem palladium-catalyzed allylic amination/[2,3]-Stevens rearrangement is reported. The unexpected diastereoselectivity of the [2,3]-Stevens rearrangement was controlled by the substitution patterns of an aromatic ring. This discovery represents a new stereocontrolling element for [2,3]-sigmatropic rearrangements in complex molecular settings
Ligand-Controlled Regiodivergence in the Copper-Catalyzed [2,3]- and [1,2]-Rearrangements of Iodonium Ylides
Despite the importance
of allylic ylide rearrangements for the
synthesis of complex molecules, the catalyst control of [2,3]- and
[1,2]-rearrangements remains an unsolved problem. We developed the
first regiodivergent [2,3]- and [1,2]-rearrangements of iodonium
ylides that are controlled by copper catalysts bearing different ligands.
In the presence of a 2,2′-dipyridyl ligand, diazoesters
and allylic iodides react via a [2,3]-rearrangement pathway. Alternatively,
a phosphine ligand favors the formation of the [1,2]-rearrangement
product. A series of α-iodoesters containing a broad range of
functional groups were obtained in high yields, regioselectivities,
and diastereoselectivities. Deuterium-labeling studies suggest
distinct mechanisms for the regioselective rearrangements
Synthesis of (±)-Amathaspiramide F and Discovery of an Unusual Stereocontrolling Element for the [2,3]-Stevens Rearrangement
A formal total synthesis of (±)-amathaspiramide F through a tandem palladium-catalyzed allylic amination/[2,3]-Stevens rearrangement is reported. The unexpected diastereoselectivity of the [2,3]-Stevens rearrangement was controlled by the substitution patterns of an aromatic ring. This discovery represents a new stereocontrolling element for [2,3]-sigmatropic rearrangements in complex molecular settings
Synthesis of (±)-Amathaspiramide F and Discovery of an Unusual Stereocontrolling Element for the [2,3]-Stevens Rearrangement
A formal total synthesis of (±)-amathaspiramide F through a tandem palladium-catalyzed allylic amination/[2,3]-Stevens rearrangement is reported. The unexpected diastereoselectivity of the [2,3]-Stevens rearrangement was controlled by the substitution patterns of an aromatic ring. This discovery represents a new stereocontrolling element for [2,3]-sigmatropic rearrangements in complex molecular settings
Synthesis of (±)-Amathaspiramide F and Discovery of an Unusual Stereocontrolling Element for the [2,3]-Stevens Rearrangement
A formal total synthesis of (±)-amathaspiramide F through a tandem palladium-catalyzed allylic amination/[2,3]-Stevens rearrangement is reported. The unexpected diastereoselectivity of the [2,3]-Stevens rearrangement was controlled by the substitution patterns of an aromatic ring. This discovery represents a new stereocontrolling element for [2,3]-sigmatropic rearrangements in complex molecular settings
Catalytic Enantioselective Allylic Amination of Unactivated Terminal Olefins via an Ene Reaction/[2,3]-Rearrangement
The enantioselective allylic amination of unactivated
terminal
olefins represents a direct and attractive strategy for the synthesis
of enantioenriched amines. We have developed the first use of a nitrogen-containing
reagent and a chiral palladium catalyst to convert unfunctionalized
olefins into enantioenriched allylic amines via an ene reaction/[2,3]-rearrangement
Stereoselective Synthesis of Functionalized Cyclic Amino Acid Derivatives via a [2,3]-Stevens Rearrangement and Ring-Closing Metathesis
Unnatural cyclic amino acids are valuable tools in biomedical research and drug discovery. A two-step stereoselective strategy for converting simple glycine-derived aminoesters into unnatural cyclic amino acid derivatives has been developed. The process includes a palladium-catalyzed tandem allylic amination/[2,3]-Stevens rearrangement followed by a ruthenium-catalyzed ring-closing metathesis. The [2,3]-rearrangement proceeds with high diastereoselectivity through an <i>exo</i> transition state. Oppolzer’s chiral auxiliary was utilized to access an enantiopure cyclic amino acid by this approach, which will enable future biological applications