Wege aus der Vertrauenskrise

Psychology faces a so-called crisis of confidence as does sport psychology (see title of this special issue). While the debate on its causes and consequences is lively, the deduction of individual opportunities to collectively increase trust is missing. We propose ways out of this crisis and above all describe individual steps toward a reliable and open science. Reliable science refers to the publication of robust effects, as well as to direct and conceptual replications, and open science refers to transparency regarding the design (preregistration), the conducting (open material), and the analysis (open data, reproducible code) of scientific studies. The commitment to reliable and open science will change our behavior in the diverse roles within the scientific system (e.g., as researchers, reviewers, supervisors, editors, or members of commissions). In this sense, we consider the current discussion as a chance to enhance the trustworthiness of our findings and to ultimately create justified confidence.Die Psychologie, und mit ihr auch die Sportpsychologie, befindet sich in einer sogenannten Vertrauenskrise (siehe Titel des Themenhefts). Während die Diskussion ihrer Ursachen und Konsequenzen lebendig geführt wird, fehlt es an der Herausarbeitung individueller Möglichkeiten, Vertrauen wieder kollektiv herzustellen. In diesem Beitrag zeigen wir Wege aus dieser Vertrauenskrise auf und beschreiben insbesondere individuelle Schritte hin zu verlässlichem und offenem Forschen: Verlässliches Forschen bezieht sich auf das Publizieren von robusten Ergebnissen, sowie von direkten und konzeptuellen Replikationsstudien und offenes Forschen auf die Transparenz hinsichtlich der Planung (Präregistrierung), der Durchführung (Open Material) und der Analyse (Open Data, Reproducible Code) wissenschaftlicher Untersuchungen. Das Bekenntnis zu verlässlicher und offener Forschung wird unser Handeln in den verschiedenen Rollen im Wissenschaftssystem (als Forscher, Reviewer, Herausgeber, Betreuer, Kommissionsmitglied etc.) verändern. In diesem Sinne begreifen wir in diesem Beitrag die momentane Diskussion als Chance, die Zuverlässigkeit unserer Befunde nachhaltig zu steigern und langfristig gerechtfertigtes Vertrauen zu schaffen

Wege aus der Vertrauenskrise

Psychology faces a so-called crisis of confidence as does sport psychology (see title of this special issue). While the debate on its causes and consequences is lively, the deduction of individual opportunities to collectively increase trust is missing. We propose ways out of this crisis and above all describe individual steps toward a reliable and open science. Reliable science refers to the publication of robust effects, as well as to direct and conceptual replications, and open science refers to transparency regarding the design (preregistration), the conducting (open material), and the analysis (open data, reproducible code) of scientific studies. The commitment to reliable and open science will change our behavior in the diverse roles within the scientific system (e.g., as researchers, reviewers, supervisors, editors, or members of commissions). In this sense, we consider the current discussion as a chance to enhance the trustworthiness of our findings and to ultimately create justified confidence.Die Psychologie, und mit ihr auch die Sportpsychologie, befindet sich in einer sogenannten Vertrauenskrise (siehe Titel des Themenhefts). Während die Diskussion ihrer Ursachen und Konsequenzen lebendig geführt wird, fehlt es an der Herausarbeitung individueller Möglichkeiten, Vertrauen wieder kollektiv herzustellen. In diesem Beitrag zeigen wir Wege aus dieser Vertrauenskrise auf und beschreiben insbesondere individuelle Schritte hin zu verlässlichem und offenem Forschen: Verlässliches Forschen bezieht sich auf das Publizieren von robusten Ergebnissen, sowie von direkten und konzeptuellen Replikationsstudien und offenes Forschen auf die Transparenz hinsichtlich der Planung (Präregistrierung), der Durchführung (Open Material) und der Analyse (Open Data, Reproducible Code) wissenschaftlicher Untersuchungen. Das Bekenntnis zu verlässlicher und offener Forschung wird unser Handeln in den verschiedenen Rollen im Wissenschaftssystem (als Forscher, Reviewer, Herausgeber, Betreuer, Kommissionsmitglied etc.) verändern. In diesem Sinne begreifen wir in diesem Beitrag die momentane Diskussion als Chance, die Zuverlässigkeit unserer Befunde nachhaltig zu steigern und langfristig gerechtfertigtes Vertrauen zu schaffen

The study design of UDRIVE: the Naturalistic Driving Study across Europe for cars, trucks and scooters

Purpose: UDRIVE is the first large-scale European Naturalistic Driving Study on cars, trucks and powered two wheelers. The acronym stands for "European naturalistic Driving and Riding for Infrastructure & Vehicle safety and Environment". The purpose of the study is to gain a better understanding of what happens on the road in everyday traffic situations. Methods: The paper describes Naturalistic Driving Studies, a method which provides insight into the actual real-world behaviour of road users, unaffected by experimental conditions and related biases. Naturalistic driving can be defined as a study undertaken to provide insight into driver behaviour during everyday trips by recording details of the driver, the vehicle and the surroundings through unobtrusive data gathering equipment and without experimental control. Data collection will take place in six EU Member States. Results: Road User Behaviour will be studied with a focus on both safety and environment. The UDRIVE project follows the steps of the FESTA-V methodology, which was originally designed for Field Operational Tests. Conclusions: Defining research questions forms the basis of the study design and the specification of the recording equipment. Both will be described in this paper. Although the project has just started collecting data from drivers, we consider the process of designing the study as a major result which may help other initiatives to set up similar studies

Psychological well-being in Europe after the outbreak of war in Ukraine

The Russian invasion of Ukraine on February 24, 2022, has had devastating effects on the Ukrainian population and the global economy, environment, and political order. However, little is known about the psychological states surrounding the outbreak of war, particularly the mental well-being of individuals outside Ukraine. Here, we present a longitudinal experience-sampling study of a convenience sample from 17 European countries (total participants = 1,341, total assessments = 44,894, countries with >100 participants = 5) that allows us to track well-being levels across countries during the weeks surrounding the outbreak of war. Our data show a significant decline in well-being on the day of the Russian invasion. Recovery over the following weeks was associated with an individual’s personality but was not statistically significantly associated with their age, gender, subjective social status, and political orientation. In general, well-being was lower on days when the war was more salient on social media. Our results demonstrate the need to consider the psychological implications of the Russo-Ukrainian war next to its humanitarian, economic, and ecological consequences

Toxicity Testing in the 21st Century: Defining New Risk Assessment Approaches Based on Perturbation of Intracellular Toxicity Pathways

The approaches to quantitatively assessing the health risks of chemical exposure have not changed appreciably in the past 50 to 80 years, the focus remaining on high-dose studies that measure adverse outcomes in homogeneous animal populations. This expensive, low-throughput approach relies on conservative extrapolations to relate animal studies to much lower-dose human exposures and is of questionable relevance to predicting risks to humans at their typical low exposures. It makes little use of a mechanistic understanding of the mode of action by which chemicals perturb biological processes in human cells and tissues. An alternative vision, proposed by the U.S. National Research Council (NRC) report Toxicity Testing in the 21st Century: A Vision and a Strategy, called for moving away from traditional high-dose animal studies to an approach based on perturbation of cellular responses using well-designed in vitro assays. Central to this vision are (a) “toxicity pathways” (the innate cellular pathways that may be perturbed by chemicals) and (b) the determination of chemical concentration ranges where those perturbations are likely to be excessive, thereby leading to adverse health effects if present for a prolonged duration in an intact organism. In this paper we briefly review the original NRC report and responses to that report over the past 3 years, and discuss how the change in testing might be achieved in the U.S. and in the European Union (EU). EU initiatives in developing alternatives to animal testing of cosmetic ingredients have run very much in parallel with the NRC report. Moving from current practice to the NRC vision would require using prototype toxicity pathways to develop case studies showing the new vision in action. In this vein, we also discuss how the proposed strategy for toxicity testing might be applied to the toxicity pathways associated with DNA damage and repair

Musculoskeletal Response to Whole-Body Vibration During Fracture Healing in Intact and Ovariectomized Rats

This study investigated the effect of vibration on bone healing and muscle in intact and ovariectomized rats. Thirty ovariectomized (at 3 months of age) and 30 intact 5-month old female Sprague-Dawley rats underwent bilateral metaphyseal osteotomy of tibia. Five days later, half of the ovariectomized and of the intact rats were exposed to whole-body vertical vibration (90 Hz, 0.5 mm, 4 × g acceleration) for 15 min twice a day during 30 days. The other animals did not undergo vibration. After decapitation of rats, one tibia was used for computed tomographic, biomechanical, and histological analyses; the other was used for gene expression analyses of alkaline phosphatase (Alp), osteocalcin (Oc), tartrate-resistant acid phosphatase 1, and insulinlike growth factor 1. Serum Alp and Oc were measured. Mitochondrial activity, fiber area and distribution, and capillary densities were analyzed in M. gastrocnemius and M. longissimus. We found that vibration had no effect on body weight and food intake, but it improved cortical and callus densities (97 vs. 99%, 72 vs. 81%), trabecular structure (9 vs. 14 trabecular nodes), blood supply (1.7 vs. 2.1 capillaries/fiber), and oxidative metabolism (17 vs. 23 pmol O2/s/mg) in ovariectomized rats. Vibration generally increased muscle fiber size. Tibia biomechanical properties were diminished after vibration. Oc gene expression was higher in vibrated rats. Serum Alp was increased in ovariectomized rats. In ovariectomized rats, vibration resulted in an earlier bridging; in intact rats, callus bridging occurred later after vibration. The chosen vibration regimen (90 Hz, 0.5 mm, 4 × g acceleration, 15 min twice a day) was effective in improving musculoskeletal tissues in ovariectomized rats but was not optimal for fracture healing

Crowdsourcing hypothesis tests: Making transparent how design choices shape research results

To what extent are research results influenced by subjective decisions that scientists make as they design studies? Fifteen research teams independently designed studies to answer fiveoriginal research questions related to moral judgments, negotiations, and implicit cognition. Participants from two separate large samples (total N > 15,000) were then randomly assigned to complete one version of each study. Effect sizes varied dramatically across different sets of materials designed to test the same hypothesis: materials from different teams renderedstatistically significant effects in opposite directions for four out of five hypotheses, with the narrowest range in estimates being d = -0.37 to +0.26. Meta-analysis and a Bayesian perspective on the results revealed overall support for two hypotheses, and a lack of support for three hypotheses. Overall, practically none of the variability in effect sizes was attributable to the skill of the research team in designing materials, while considerable variability was attributable to the hypothesis being tested. In a forecasting survey, predictions of other scientists were significantly correlated with study results, both across and within hypotheses. Crowdsourced testing of research hypotheses helps reveal the true consistency of empirical support for a scientific claim.</div

Psychological well-being in Europe after the outbreak of war in Ukraine

The Russian invasion of Ukraine on February 24, 2022, has had devastating effects on the Ukrainian population and the global economy, environment, and political order. However, little is known about the psychological states surrounding the outbreak of war, particularly the mental well-being of individuals outside Ukraine. Here, we present a longitudinal experience-sampling study of a convenience sample from 17 European countries (total participants = 1,341, total assessments = 44,894, countries with >100 participants = 5) that allows us to track well-being levels across countries during the weeks surrounding the outbreak of war. Our data show a significant decline in well-being on the day of the Russian invasion. Recovery over the following weeks was associated with an individual’s personality but was not statistically significantly associated with their age, gender, subjective social status, and political orientation. In general, well-being was lower on days when the war was more salient on social media. Our results demonstrate the need to consider the psychological implications of the Russo-Ukrainian war next to its humanitarian, economic, and ecological consequences

Die Nutzung hepatischer Funktionen fuer in vitro-Verfahren zur Pruefung von Stoffen mit dem Ziel der Einsparung von Tierversuchen. Teilprojekt 16: Standardisierung und Weiterentwicklung von in vitro-Metabolisierungssystemen mit kryokonservierten Hepatozyten des Beagle-Hundes Abschlussbericht

Available from TIB Hannover: DtF QN1(68,33) / FIZ - Fachinformationszzentrum Karlsruhe / TIB - Technische InformationsbibliothekSIGLEBundesministerium fuer Bildung, Wissenschaft, Forschung und Technologie, Bonn (Germany)DEGerman