Being forced? Getting far? Speaking the language? What matters in the process of going abroad as a student?

Student mobility is a common phenomenon in Luxembourg, as almost every student spends a period abroad before graduating. Based on material from this “hyper-mobile” academic context, we will focus on the first phase of going abroad. First, we will analyse how the idea to study abroad is related to different notions of forced or non-forced mobility. Second, we will turn to the choice of destination, focussing on geographical distance and language distance between the country of origin and the place of destination. Geographical distance is not a goal as such but is a proxy for other dimensions, e.g. greater distance can be equated with a wish to try out new things and start a new life phase while shorter distance emphasises strong embeddedness in pre-existing social ties and obligations. In terms of language, students mostly choose countries where one of Luxembourg’s official languages is spoken (either because they have mastered it or because they would like to improve it for professional reasons), and countries where an additional language can be learnt or practised. Our results show that studying abroad is not the decision of a moment, but rather a process embedded in students’ past, present and future as well as in their social surroundings

Can a connectionist model explain the processing of regularly and irregularly inflected words in German as L1 and L2?

The connectionist model is a prevailing model of the structure and functioning of the cognitive system of the processing of morphology. According to this model, the morphology of regularly and irregularly inflected words (e.g., verb participles and noun plurals) is processed in the same cognitive network. A validation of the connectionist model of the processing of morphology in German as L2 has yet to be achieved. To investigate L2-specific aspects, we compared a group of L1 speakers of German with speakers of German as L2. L2 and L1 speakers of German were assigned to their respective group by their reaction times in picture naming prior to the central task. The reaction times in the lexical decision task of verb participles and noun plurals were largely consistent with the assumption of the connectionist model. Interestingly, speakers of German as L2 showed a specific advantage for irregular compared with regular verb participles

Quantification of heat-stress related mortality hazard, vulnerability and risk in Berlin, Germany

Many studies have addressed the challenge of heat stress for human health in recent years. However, appropriate concepts and methods for quantifying heat-stress hazards, vulnerabilities and risks are yet under development. The objective of this study is to test the applicability of a risk concept and associated event-based risk-analysis method for quantifying heat-stress related mortality. The study reveals that about 5 % of all deaths between 2001 and 2010 in Ber­lin can statistically be related to elevated air temperatures. Most of the affected people are 65 years or older, while the mortality of people below 65 years shows only weak statistical correlation to air temperature. Mean daily air tempera­ture was best suitable for risk analysis. The results demonstrate that the novel approach for quantitative risk analysis delivers statistically highly significant results on the city scale when analysing heat stress on an event basis. Performing the risk analysis on a spatially distributed data basis for city districts would allow to account for spatial variations of ur­ban climates and demographic properties. Using indoor climate data is expected to provide new insight into heat-stress related mortality risks, particularly for highly vulnerable persons like elderly persons or patients residing in hospitals

BioCAS: Biometeorological Climate impact Assessment System for building-scale impact assessment of heat-stress related mortality

An urban climate analysis system for Seoul was combined with biometeorological models for the spatially distributed assessment of heat stress risks. The Biometeorological Climate impact Assessment System (BioCAS) is based on the Climate Analysis Seoul (CAS) workbench which provides urban planners with gridded data relevant for local climate assessment at 25 m and 5 m spatial resolutions. The influence of building morphology and vegetation on mean radiant temperature Tmrt was simulated by the SOLWEIG model. Gridded hourly perceived temperature PT was computed using the Klima-Michel Model for a hot day in 2012. Daily maximum perceived temperature PTmax was then derived from these data and applied to an empirical-statistical model that explains the relationship between PTmax and excess mortality rate rEM in Seoul. The resultant rEM map quantifies the detrimental impact of hot weather at the building scale. Mean (maximum) values of rEM in old and new town areas in an urban re-development site in Seoul were estimated at 2.3 % (50.7 %) and 0 % (8.6 %), respectively, indicating that urban re-development in the new town area has generally resulted in a strong reduction of heat-stress related mortality. The study illustrates that BioCAS can generally be applied for the quantification of the impacts of hot weather on human health for different urban development scenarios. Further improvements are required, particularly to consider indoor climate conditions causing heat stress, as well as socio-economic status and population structure of local residents

Designing the (Most) Mobile University: The Centrality of International Student Mobility in Luxembourg’s Higher Education Policy Discourse

The nexus of national educational and migration policies and international student mobility (ISM) in Europe becomes strikingly visible in Luxembourg. ISM is central for higher education policy in Luxembourg, but also for larger questions of social integration and economic development. Based on a discourse analysis of the political debates surrounding the foundation of the University of Luxembourg in 2003, we analyze how and why ISM became a cornerstone of higher education policy in Luxembourg. Our findings reveal that, on the one hand, incoming student mobility — and the establishment of an international research university — was and is seen as a means of competing for the best and brightest, regionally and globally, and of securing human resources to satisfy a booming, internationalized labor market. On the other hand, outgoing student mobility has traditionally been viewed as the main mechanism to establish international networks across Europe and foster elites back home. Both incoming and outgoing mobility are thought necessary to establish and maintain a competitive and sustainable knowledge economy. Reconstructing the underlying rationales behind the support for ISM as the key to higher education policy, we explain why Luxembourg currently has the highest proportion of ISM worldwide

NSP-Dependent Simple Nitrile Formation Dominates upon Breakdown of Major Aliphatic Glucosinolates in Roots, Seeds, and Seedlings of Arabidopsis thaliana Columbia-0

One of the best-studied plant defense systems, the glucosinolate-myrosinase system of the Brassicales, is composed of thioglucosides known as glucosinolates and their hydrolytic enzymes, the myrosinases. Tissue disruption brings these components together, and bioactive products are formed as a consequence of myrosinase-catalyzed glucosinolate hydrolysis. Among these products, isothiocyanates have attracted most interest as chemical plant defenses against herbivores and pathogens and health-promoting compounds in the human diet. Previous research has identified specifier proteins whose presence results in the formation of alternative product types, e.g., nitriles, at the expense of isothiocyanates. The biological roles of specifier proteins and alternative breakdown products are poorly understood. Here, we assessed glucosinolate breakdown product profiles obtained upon maceration of roots, seedlings and seeds of Arabidopsis thaliana Columbia-0. We identified simple nitriles as the predominant breakdown products of the major endogenous aliphatic glucosinolates in root, seed, and seedling homogenates. In agreement with this finding, genes encoding nitrile-specifier proteins (NSPs) are expressed in roots, seeds, and seedlings. Analysis of glucosinolate breakdown in mutants with T-DNA insertions in any of the five NSP genes demonstrated, that simple nitrile formation upon tissue disruption depended almost entirely on NSP2 in seeds and mainly on NSP1 in seedlings. In roots, about 70–80% of the nitrile-forming activity was due to NSP1 and NSP3. Thus, glucosinolate breakdown product profiles are organ-specifically regulated in A. thaliana Col-0, and high proportions of simple nitriles are formed in some parts of the plant. This should be considered in future studies on biological roles of the glucosinolate-myrosinase system

Bored at home?—A systematic review on the effect of environmental enrichment on the welfare of laboratory rats and mice

Boredom is an emotional state that occurs when an individual has nothing to do, is not interested in the surrounding, and feels dreary and in a monotony. While this condition is usually defined for humans, it may very well describe the lives of many laboratory animals housed in small, barren cages. To make the cages less monotonous, environmental enrichment is often proposed. Although housing in a stimulating environment is still used predominantly as a luxury good and for treatment in preclinical research, enrichment is increasingly recognized to improve animal welfare. To gain insight into how stimulating environments influence the welfare of laboratory rodents, we conducted a systematic review of studies that analyzed the effect of enriched environment on behavioral parameters of animal well–being. Remarkably, a considerable number of these parameters can be associated with symptoms of boredom. Our findings show that a stimulating living environment is essential for the development of natural behavior and animal welfare of laboratory rats and mice alike, regardless of age and sex. Conversely, confinement and under-stimulation has potentially detrimental effects on the mental and physical health of laboratory rodents. We show that boredom in experimental animals is measurable and does not have to be accepted as inevitable

<i>Mycoplasma pneumoniae</i> IgG positivity is associated with tic severity in chronic tic disorders

Infectious pathogens may represent an environmental risk factor for chronic tic disorders (CTD). This cross-sectional study aimed to determine whether Mycoplasma pneumoniae (M. pneumoniae) IgG positivity is associated with the presence or severity of tics. We compared M. pneumoniae IgG positivity across three groups: children and adolescents (3-16 years) with CTD (CTD group; n=302); siblings (3-10 years) of people with CTD who developed tics within a seven-year follow-up period (tic onset group; n=51); siblings (4-10 years) who did not develop tics within the study period and were ≥ 10-years-old at their last assessment (unaffected group; n=88). The relationship between M. pneumoniae IgG positivity and the presence and severity of tics was analysed using multilevel models controlling for site, family relatedness, sex, age, presence of comorbid obsessive-compulsive and/or attention-deficit/hyperactivity disorder and use of psychotropic medication. M. pneumoniae IgG positivity was not associated with the presence of CTD, or the first onset of tics as compared to siblings who remained unaffected. M. pneumoniae IgG positivity was associated with a higher tic severity score within the CTD group (β=2.64, s.e.=1.15, p=0.02). It is possible that M. pneumoniae infection influences tic severity in CTD or, that having more severe tics, increases the risk of infection. However, it is more likely that the association observed in this study reflects a propensity toward enhanced immune responses in people with CTD and that, rather than a causal relationship, infection and greater tic severity are indirectly linked via shared underlying immune mechanisms

Molecular phylogeny and taxonomic revision of the sportive lemurs (Lepilemur, Primates)

BACKGROUND: The number of species within the Malagasy genus Lepilemur and their phylogenetic relationships is disputed and controversial. In order to establish their evolutionary relationships, a comparative cytogenetic and molecular study was performed. We sequenced the complete mitochondrial cytochrome b gene (1140 bp) from 68 individuals representing all eight sportive lemur species and most major populations, and compared the results with those obtained from cytogenetic studies derived from 99 specimens. RESULTS: Interspecific genetic variation, diagnostic characters and significantly supported phylogenetic relationships were obtained from the mitochondrial sequence data and are in agreement with cytogenetic information. The results confirm the distinctiveness of Lepilemur ankaranensis, L. dorsalis, L. edwardsi, L. leucopus, L. microdon, L. mustelinus, L. ruficaudatus and L. septentrionalis on species level. Additionally, within L. ruficaudatus large genetic differences were observed among different geographic populations. L. dorsalis from Sahamalaza Peninsula and from the Ambanja/Nosy Be region are paraphyletic, with the latter forming a sister group to L. ankaranensis. CONCLUSION: Our results support the classification of the eight major sportive lemur taxa as independent species. Moreover, our data indicate further cryptic speciation events within L. ruficaudatus and L. dorsalis. Based on molecular data we propose to recognize the sportive lemur populations from north of the Tsiribihina River, south of the Betsiboka River, and from the Sahamalaza Peninsula, as distinct species