Evaluasi Adverse Drug Reactions (Adrs) Penyakit Kanker Payudara Dengan Kemoterapi Berbasis Antrasiklin Di RSUD Prof. Dr. Margono Soekardjo Purwokerto

Breast cancer is one of the most type of cancer with highest incidence in women. one of therapy in breast cancer is anthracycline-based chemotherapy. Drugs uses increases occurance of adverse drug reactions (ADRs) that may lead endanger the health and life patients. This research is a descriptive and analytical observational research with prospective data collection methods. Data collected by interview with naranjo scale. There were 46 patients included as samples of this research. The most frequently adverse drug reactions was nausea (89.15%), vomiting (82.6%), alopecia (76.08%), anorexia (71.74%), fatigue (60.87%), diarhea (45.65%), fever (39.13%), dehydration (34.77%), sleep disorder (32.6%), oral ulceration (21.74%), and anemia (13.04%). Based on the research, the most frequently adverse drug reactions of anthracycline-based chemotherapy in patient with breast cancer was nausea. Key words: anthracycline-based chemotherapy, naranjo scale, nausea

Perbandingan Tingkat Keberhasilan Terapi Tuberkulosis Pada Puskesmas Yang Sudah Bersertifikat Iso Dan Tidak Di Kabupaten Purbalingga

Tuberculosis is a kind of disease caused by Mycobacterium tuberculosis basille. It belongs to the third most of the deadly disease after Cardiovaskuler and Respiration disease, while the first deadly disease comes from infection disease group. The aim of this research is to know the succesfull level of tuberculosis therapy between ISO certified Puskesmas (Puskesmas Padamara) and ISO uncertified puskesmas (Puskesmas Serayu Larangan) by using the succesfull indicator and the comparison of TBC\u27s cure rate with two samples chi-square test. The data was taken from medical record of all diagnosed patients whose its cure started from July 2009 until June 2010. The data then was analized to get the indicator of TBC\u27s successful level. This research shows that there is no difference between ISO 2001-2008 certified Puskesmas and ISO uncertifiedPuskesmas. Keywords : The comparison of TBC therapy, tuberculosis, ISO certificate

Identifikasi Drug Related Problems (Drps) Pengobatan Tuberkulosis Pada Pasien Rawat Jalan Di RSUD Kardinah Kota Tegal Tahun 2009

Tuberculosis is a global health problem that needs to be overcome well and appropriately. The tuberculosis treatment needs more drugs of therapy so it causes Drug Related Problems (DRPs). The aim of this research was to explore the DRPs in the tuberculosis treatment covers wrong drug, over dosage, sub therapy dosage and drug interaction. This research was retrospectively and applicated to 170 patients of out patients in RSUD Kardinah Tegal during January-December 2009. Appropriate descriptive analysis was used. The results showed that unnecessary drug interaction 98,24%, the other DRPs were wrong drug (52,94%), sub therapy dosage (29,41%) and over dosage (1,76%). According to the results of this research can be concluded that there are many mistakes which will cause problem in tuberculosis treatment. Key words : tuberculosis, DRPs, wrong drug, over dosage, sub therapy dosage, drug interaction

Tingkat Kepuasan Konsumen Apotek Di Kabupaten Banjarnegara

Has done research on the level of consumer satisfaction in the district of Banjarnegara pharmacies. The purpose of this study was to determine the level of consumer satisfaction in pharmacies Banjarnegara district. This research is descriptive analytical model with the observational approach. Sampling for this study using random sampling method with sample areas totaling 400 people of consumers. Methods of data collection is done by using a questionnaire and analyzed by the method of customer satisfaction index (CSI). The analysis showed the value of customer satisfaction index (CSI) on the dimensions of 0.8324 Responsiveness including categories very satisfied, on the assurance dimension of 0.8242 including the category of very satisfied, on the dimensions of reliability of 0.7189, including categories of content, on tangible dimension of 0 , 7704 including the categories of satisfaction and the dimensions of empathy for 0.6194 categorized quite satisfied. CSI overall value of 0.695 is in the range of values from 0.66 to 0.80 are categorized as satisfied. Levels of consumer satisfaction pharmacy Banjarnegara District is satisfied. Keywords: Level of customer satisfaction, pharmacy services, pharmacy

Tingkat Keberhasilan Terapi Tuberkulosis Di Puskesmas Kabupaten Purbalingga Tahun 2009

Research on tuberculosis treatment success rate has been performed in Purbalingga district health center in 2009. Tuberculosis is a disease caused by Mycobacterium tuberculosis bacilli. The purpose of this study was to determine the level of success of treatment for tuberculosis seen from the conversion rate, cure rate, and percentage of new case detection rate (CDR). Data retrieved from medical records that all TB patients are diagnosed and completed treatment period from January until December 2009. Data obtained 138 cases and then analyzed by descriptive The results of this study indicate that the conversion rate to 86.96% for category I and category II by 100% (target 80%). Cure rate for category I by 86.96% and for 11 categories by 100% (target 85%). And for the percentage of new case detection rate (CDR) of 60% (target 70%), the rate of crawl of 71 suspects, the proportion of smear positive TB patients were suspected of 21.59%, the proportion of pulmonary TB patients were positive among all pulmonary TB patients were 100%, proportion of children among all TB patients 6% of TB patients, case notification rate (CNR) 49 persons, 99.27% success rate of therapy. From the results of the conversion rate, cure rate, it can be concluded that the therapy of tuberculosis in health centers Purbalingga declared unsuccessful due to a percentage, new case detection rate (CDR) was still below, the standards set DEPKES. Keywords: success rate, tuberculosis, health center Purbalingg

Evaluasi Kepatuhan Dan Respon Mual Muntah Penggunaan Antiemetik Pada Pasien Kanker Payudara Yang Menjalani Kemoterapi Di RSUD Prof. Dr. Margono Soekarjo

Breast cancer is one of the cancers with the highest incidence, especially in women. The development of therapy has been implemented to improve the survival and prognosis of breast cancer patients. Breast cancer treatment is given by considering many factors, including age, menopausal status, comorbidities, stage of cancer, biological factors and history of chemotherapy. Optimization of quality of life during treatment is very important. Chemotherapy Induced Nausea vomitting (CINV) is a common side effect and can affect the quality of life of cancer patients. The aims of this study are to know response of nausea vomitting, patients adherence, relationship between adherence and response of nausea vomitting. This study is an observational study conducted by descriptive and analytic study design in Prof. Dr. Margono Soekarjo hospital. The results of this study are the nausea and vomitting response are the most in the acute emesis phase (80%) and delayed emesis (90%). A total of 79% were adherent to antiemetics therapy. There is no relationship between adherence and the response of nausea vomitting in Prof. Dr. Margono Soekarjo hospital. Key words: breast cancer, chemotherapy induced nausea and vomitting, antiemetics response, adherence

Evaluasi Pola Peresepan Berdasarkan Beers Criteria Pada Pasien Geriatri Rawat Jalan Pada Poli Penyakit Dalam Di RSUD Prof. Dr. Margono Soekarjo Purwokerto Periode Agustus 2010-maret 2011

Geriatric derived from the word geros is meaning oldest and iatriea is meaning to care. WHO set the population between the ages of 65-75 years as a geriatric ward. At this age, a decline of physiological functions of the body so that needed careful consideration in choosing a drug. Beers Criteria is a standard criteria to be specific to geriatric drug use. Beers Criteria specifically set forth basic guidelines for the surpass Drug Related Problem in geriatrics. Goal of the research is evaluating of prescription patterns in geriatric outpatient based on Beers Criteria in Geriatrics outpatient on internist division regional public hospital of Prof. Dr. Margono Soekarjo Purwokerto and all at once to see irrasionalist praescription patterns in geriatric outpatient in August 2010 to March 2011 period. The method`used was non experimental, with retrospective data collection. The analysis was done with descriptive method to get an idea of prescription patterns in geriatric outpatient on internist division based on Beers Criteria 2003. Results obtained show that during August 2010 to March 2011 period, of total 425 recipe there are 84 recipe (19,8%) that is not appropriate rational Beers Criteria 2003. The most widely prescribed drugs were diazepam 26 drug item (31,0 %), Chlordiazepoksid-clidinium 25 drug item (29,8%), Digoxin 24 drug item (28,6%), Alprazolam 6 drug item (7,1%), Ferrosi Sulfat 1 drug item (1,2%), Bisakodil 1 drug item (1,2%), Clonidine 1 drug item (1,2%) Keywords: geriatrics outpatient on internist division, beers criteria 200

Evaluasi Manajemen Pengelolaan Obat Di Puskesmas Rawat Inap Kabupaten Purbalingga Berdasarkan Tiga Besar Alokasi Dana Pengadaan Obat

A research about Evaluation of Drug Management in Public Health Centre with Lodge Care of Purbalingga Based on Three Major of Public Sector Drug. The purpose of this study to evaluate management of drug in Public Health Centre with lodge care of Purbalingga based on three major of public sector drug. This research use descriptive method with approach qualitative which supported with quantitative data. The sample's of this research are Public Health Centre of Kalimanah, Bobotsari and Rembang. The result of research show that Public Health Centre in planning was not good. Optimum stock is not be noted at stock card and there are still requested of drug outside DOEN for the Public Health Centre of Kalimanah 84,51%, Bobotsari 79,64% and Rembang 85,35%. Acceptance of drug have been done with procedure. Storing of Psikotropika drug is not according the rule and not guarantee the quality of drug. Drug distribution, operation of USAge, reporting and record-keeping have been done with procedure. Key words : Evaluation, Drug Management, Public Health Centre with lodge care, Public Sector Drug

Optimasi Metode Penetapan Ranitidin Dalam Plasma Manusia Secara in Vitro Dengan Metode Spektrofotometri Ultraviolet-visibel

Research of determination ranitidine plasma concentration in vitro has been done. This research aimed to analysis ranitidine in human plasma in vitro with Ultraviolet-Visible spectrophotometry and to get result that optimal of analysis method in human plasma in vitro with Ultraviolet-Visible spectrophotometry. A method for determination ranitidine in human plasma in vitro used UV-VIS spectrophotometry with solvent HCl 0.1 N. This research was used two method. First method the ranitidine standard solution was added early, while the second method ranitidine standard solution was added after TCA and plasma had been mixed and sentrifugated. From second method has been gotten maximum wave length 320.5 nm in finish concentration ranitidine in human plasma 500 ppm. Determination of linearity calibration curve was linear between concentration with absorbantion range of 200-600 ppm with correlation efficient (r) = 0.997 a = 0.081 and b = 9.417x10-4. The result of precision with first method to 500 ppm (CV=2.28%), while CV value to 500 ppm with second method was 1.60%. Limit of detection was 43.64 ppm, limit of quantitation was 145.48%. The accuracy of recoveries 500 ppm was 104.99%. This second method was sufficiently applicable to bioavailability and bioequivalence studies of ranitidine in human plasma in vivo. Keywords : ranitidine; human plasma; method optimation; spectrophotometry