Allopurinol-induced DRESS syndrome

A 70-year-old man was admitted to our clinic with complaints of fever, jaundice, dyspnea, and generalized rash after 3 months of allopurinol treatment for gout. On physical examination, he was found to have fever (38.5 degrees C), jaundice, and generalized maculopapular rash. Leukocytosis, eosinophilia, elevation of liver enzymes, and hyperbilirubinemia were detected in his blood analysis. Skin biopsy was consistent with drug-induced hypersensitivity. He was diagnosed as Drug Rash with Eosinophilia and Systemic Symptoms (DRESS). Allopurinol treatment was stopped and steroid treatment was launched. At day 24 of admission, the patient died because of multiple organ failure

Five methods for detection of Helicobacter pylori in the Turkish population

AIM: To compare culture analysis, Helicobacter pylori (H. pylori) stool antigen (HpSA) test, polymerase chain reaction (PCR) and fluorescence in situ hybridization (FISH) for H. pylori detection

Transient postpartum diabetes insipidus associated with HELLP syndrome

Diabetes insipidus in pregnancy has different causes. The association of diabetes insipidus with disturbances of liver function has been reported, however, diabetes insipidus has rarely been reported in HELLP syndrome. We present a 23-year-old primigravida with a singleton gestation complicated by HELLP syndrome who developed postpartum diabetes insipidus. Labor was induced promptly to terminate pregnancy because of intrauterine fetal death and liver dysfunction. 1-deamino-8-D-arginine-vasopressin was administered. Diabetes insipidus and liver dysfunction resolved within 2 weeks. Development of diabetes insipidus may result from increased vasopressinase activity mainly caused by deterioration of liver functions caused by HELLP syndrome. In pregnant women with liver disease as a result of any cause, the development of diabetes insipidus should be assessed with particular attention

Compte-rendu de la 191e séance. Assemblée générale du 6 mars 1977

Bonnemain Henri. Compte-rendu de la 191e séance. Assemblée générale du 6 mars 1977. In: Revue d'histoire de la pharmacie, 65ᵉ année, n°233, 1977. pp. 112-122

Evaluation Of The Diagnostic Criteria Of Restless Leg Syndrome In Hemodialysis Patients

Aim: In diagnosis of restless leg syndrome (RLS), seen frequently in hemodialysis patients, minimal criteria of International RLS Study Group have been commonly used. Our purpose is to investigate the significance of minimal criteria of International RLS Study Group for the diagnosis of RLS in hemodialysis patients in our district. Methods: We investigated the criteria of International RLS Study Group in 68 hemodialysis patients in three dialysis units of Afyonkarahisar city center. Twenty four patients were excluded due to absence of first criteria. Forty four patients answered positively to first question were evaluated for the diagnosis of RLS according to minimal criteria including 4 questions and neurological examination. Results: Among 44 (20 men, 24 women) hemodialysis patients mean age was 51+/-16.1 years and dialysis period was 25 (3-190) months. According to minimal criteria for diagnosis of RLS number of patients considered as positively responded to all four questions was 15 (%34.1); however number of real patients determined on neurological examination was 31 (%70.5). In the same group difference between RLS prevalence determined according to these two criteria was statistically significant (P = 0.001). Conclusion: All patients answered positively to at least first question for diagnosis of RLS, which affects quality of life, morbidity and mortality in HD patients through sleep disorders, should be evaluated in detail

Retrograde dilation of a complex radiation-induced esophageal stricture through percutaneous gastrostomy

Upper esophageal strictures occur in approximately 3-4% of patients who receive radiotherapy for head and neck cancers. The standart initial treatment is dilation by using bougie or through-the-scope balloon dilators. Endoscopic treatment requires the passage of a guidewire through the stricture which cannot be accomplished in some of the patients with complex strictures. Retrograde dilation of esophageal strictures through a mature percutaneous gastrostomy tract have been reported in a limited number of cases and small case series up to date and can be considered as a rescue treatment before considering surgery in such patients. Herein we report retrograde dilatation of a radiation-induced complex esophageal stricture through the percutaneous gastrostomy tract in a patient with operated larynx cancer