Chronic course of Ixodes tick borreliosis in Krasnoyarsk region

The purpose of the study – the optimization of clinical diagnosis of chronic course of Ixodes tick-borne borreliosis based on indicators of immune and cytokine status of patients.Materials and Methods: clinical and immunological study of patients with chronic Ixodes tick-borne borreliosis in the Krasnoyarsk region. The observations were made on 205 patients for 1,5 years. The diagnosis was based on clinical and epidemiological data confirmed the identification of specific antibodies to borrelia by ELISA. The indices of cellular and humoral immune system, phagocytosis, cytokine (interleukin-1β, 4, 8 , tumor necrosis factor-α).Results: Show Part chronicity of infection after an noneritemic form of the disease (37,5%) and combined forms of Ixodes tick-borne borreliosis with tick-borne encephalitis (33,2%). Clinical manifestations were characterized by the involvement in the pathological process of the musculoskeletal system (42,9%) and combined lesions to the nervous system (38.5%). A rare variant of the chronic course of borreliosis was central nervous system as the onset of the disease (3,5%). Common infectious syndrome relapse accompanied by autonomic dysfunction with prevalence parasimpatotonus (59,0%) and simpatotonus (41,0%), and febrile reactions (71,2%) were more subfebrile with fever (51,2%).Conclusion: pathogenetic mechanisms of chronic course of Ixodes tick-borne borreliosis closely associated with inflammation and immune-mediated reactions of the organism , and are characterized by the presence of cellular immunodeficiency, insolvency phagocytosis, suppression of the synthesis of interleukin-4 and interleukin-8 intensive products

Dephasing times in quantum dots due to elastic LO phonon-carrier collisions

Interpretation of experiments on quantum dot (QD) lasers presents a challenge: the phonon bottleneck, which should strongly suppress relaxation and dephasing of the discrete energy states, often seems to be inoperative. We suggest and develop a theory for an intrinsic mechanism for dephasing in QD's: second-order elastic interaction between quantum dot charge carriers and LO-phonons. The calculated dephasing times are of the order of 200 fs at room temperature, consistent with experiments. The phonon bottleneck thus does not prevent significant room temperature dephasing.Comment: 4 pages, 1 figure, accepted for Phys. Rev. Let

Features of shear transformation texture in seamless pipes

Microstructure and texture in seamless 0.08C-Cr-Mo-V, 0.25C-Cr-Mo-V-Nb, 0.08-13Cr-3Ni-Mo-V-Nb, and 18Cr-9Ni steel pipes are studied in the as-rolled and heat-treated states using orientation EBSD microscopy. It has been found that all types of microstructure (ferrite, martensite, and bainite) in products, both after hot rolling and after heat treatment, have well-defined axial crystallographic texture, where the direction is predominately perpendicular to the pipe surface. It is demonstrated that texture formation in heat-treated states is inherited due to the following factors important for the rules of orientation selection during the γ→α phase transformation: 1) occurrence of stable orientation of austenite grains resulted from straining; 2) special misorientation (boundaries) of austenite grains where transformation starts; 3) orientation relationships known for phase transformation; 4) thermal stresses in a product, formed during cooling. The latter can be considered as factor determining special texture in seamless steel pipes. © 2018 Author(s)

Genetic environment of the blaKPC-2 gene in a Klebsiella pneumoniae isolate that may have been imported to Russia from Southeast Asia

The nucleotide sequence of a blaKPC-2-harboring plasmid (pKPCAPSS) from Klebsiella pneumoniae ST273 isolated in Saint Petersburg, Russia, from a patient with history of recent travel to Vietnam is presented. This 127,970-bp plasmid possessed both IncFII and IncR replicons. blaKPC-2 was localized on a hypothetical mobile element. This element was flanked by 38-bp inverted Tn3 repeats and included a Tn3-specific transposase gene, macrolide resistance operon (mphA-mrx-mphR), and a fragment of blaTEM with unique polymorphisms. © 2017 American Society for Microbiology. All Rights Reserved

ХРОНИЧЕСКОЕ ТЕЧЕНИЕ ИКСОДОВЫХ КЛЕЩЕВЫХ БОРРЕЛИОЗОВ В КРАСНОЯРСКОМ КРАЕ

The purpose of the study – the optimization of clinical diagnosis of chronic course of Ixodes tick-borne borreliosis based on indicators of immune and cytokine status of patients.Materials and Methods: clinical and immunological study of patients with chronic Ixodes tick-borne borreliosis in the Krasnoyarsk region. The observations were made on 205 patients for 1,5 years. The diagnosis was based on clinical and epidemiological data confirmed the identification of specific antibodies to borrelia by ELISA. The indices of cellular and humoral immune system, phagocytosis, cytokine (interleukin-1β, 4, 8 , tumor necrosis factor-α).Results: Show Part chronicity of infection after an noneritemic form of the disease (37,5%) and combined forms of Ixodes tick-borne borreliosis with tick-borne encephalitis (33,2%). Clinical manifestations were characterized by the involvement in the pathological process of the musculoskeletal system (42,9%) and combined lesions to the nervous system (38.5%). A rare variant of the chronic course of borreliosis was central nervous system as the onset of the disease (3,5%). Common infectious syndrome relapse accompanied by autonomic dysfunction with prevalence parasimpatotonus (59,0%) and simpatotonus (41,0%), and febrile reactions (71,2%) were more subfebrile with fever (51,2%).Conclusion: pathogenetic mechanisms of chronic course of Ixodes tick-borne borreliosis closely associated with inflammation and immune-mediated reactions of the organism , and are characterized by the presence of cellular immunodeficiency, insolvency phagocytosis, suppression of the synthesis of interleukin-4 and interleukin-8 intensive products.Цель исследования – оптимизация клинической диагностики хронического течения иксодовых клещевых боррелиозов с учетом показателей иммунного и цитокинового статусов пациентов.Материалы и методы: проведено клинико-иммунологическое обследование больных хроническим иксодовым клещевым боррелиозом в Красноярском крае. Наблюдения выполнены на 205 пациентах в течение 1,5 лет. Диагноз устанавливали на основании клинико- эпидемиологических сведений, подтверждали выявлением специфических антител к боррелиям методом иммуноферментного анализа. Определяли показатели клеточного и гуморального звеньев иммунной системы, фагоцитоза, цитокины (интерлейкин-1β, 4, 8, фактор некроза опухоли-α).Результаты исследования: показана частая хронизация инфекционного процесса после перенесенных безэритемной формы заболевания (37,5%) и сочетанных форм иксодового клещевого боррелиоза с клещевым энцефалитом (33,2%). Клинические проявления характеризовались вовлечением в патологический процесс опорно-двигательного аппарата (42,9%) и его сочетанным поражением с нервной системой (38,5%). Редким вариантом хронического течения боррелиоза являлось поражение центральной нервной системы как дебюта заболевания (3,5%). Общеинфекционный синдром в рецидив заболевания сопровождался вегетативными дисфункциями с преобладанием парасимпатотонуса (59,0%) и симпатотонуса (41,0%) и лихорадочными реакциями (71,2%), чаще с субфебрильным повышением температуры тела (51,2%).Заключение: патогенетические механизмы хронического течения иксодовых клещевых боррелиозов тесно связаны с воспалительным процессом и иммуноопосредованными реакциями организма и характеризуются наличием клеточного иммунодефицита, несостоятельностью фагоцитоза, подавлением синтеза интерлейкина-4 и интенсивной продукцией интерлейкина-8

Broadening of Plasmonic Resonance Due to Electron Collisions with Nanoparticle Boundary: а Quantum Mechanical Consideration

We present a quantum mechanical approach to calculate broadening of plasmonic resonances in metallic nanostructures due to collisions of electrons with the surface of the structure. The approach is applicable if the characteristic size of the structure is much larger than the de Broglie electron wavelength in the metal. The approach can be used in studies of plasmonic properties of both single nanoparticles and arrays of nanoparticles.Comment: 9 page

Optical Identification and Spectroscopic Redshift Measurements of 216 Galaxy Clusters from the SRG/eROSITA All-Sky Survey

We present the results of the optical identification and spectroscopic redshift measurements of 216 galaxy clusters detected in the SRG/eROSITA all-sky X-ray survey. The spectroscopic observations were performed in 2020-2023 with the 6-m BTA telescope at the Special Astrophysical Observatory of the Russian Academy of Sciences, the 2.5-m telescope at the Caucasus Mountain Observatory of the Sternberg Astronomical Institute of the Moscow State University, the 1.6-m AZT-33IK telescope at the Sayan Solar Observatory of the Institute of Solar-Terrestrial Physics of the Siberian Branch of the Russian Academy of Sciences, and the 1.5-m Russian-Turkish telescope (RTT-150) at the T\"{U}B\.{I}TAK Observatory. For all of the galaxy clusters presented here the spectroscopic redshift measurements have been obtained for the first time. Of these, 139 galaxy clusters have been detected for the first time in the SRG/eROSITA survey and 22 galaxy clusters are at redshifts $z_{spec} \gtrsim 0.7$, including three at $z_{spec} \gtrsim 1$. Deep direct images with the rizJK filters have also been obtained for four distant galaxy clusters at $z_{spec} > 0.7$. For these observations the most massive clusters are selected. Therefore, most of the galaxy clusters presented here most likely will be included in the cosmological samples of galaxy clusters from the SRG/eROSITA survey