Angiogenesis inhibitors in cancer therapeutics

In the era molecular pharmacology, development of angiogenesis inhibitors is certainly a master discovery .There are specific angiogenesis inhibitors are being used in cancer and various endogenous anti-angiogenesis molecules are discovered .This review is a coverage of basic anti-angiogenic molecule like bevacizumab and other newer targets, after explaining the basic physiology of new vessel formation which helps in better understanding of these drugs.

USE OF TECHNOLOGY IN E-COMMERCE BUSINESSES WITH SPECIAL REFERENCE TO SERVICE SECTORS

The use of electronic commerce by business in developed countries as well as developing countries has grown considerably in the past few years. E- commerce businesses are capturing the worldwide markets very easily and helping in earning profits. The use of E-commerce in service sectors is contributing in national income of the country and also generating employment opportunities in India. There are various Indian service sectors has done tremendous recognition not only in Indian markets but also world markets. The India’s telecom sector is growing and became popular in world market in providing better services to overseas buyers. E-commerce use in service sector enables the marketers to reach all areas of the world with minimal cost. It is very important to know about the challenges and opportunities in service sector using of e-commerce in India. The above study has taken for the study by the researcher

Putting Women's Health Care Disparities on the Map: Examining Racial and Ethnic Disparities at the State Level

Assesses the racial/ethnic disparities in women's health status, access to and utilization of health care, and social factors such as poverty and gender wage gap by state. Examines how healthcare payment and worker shortages affect access to care

Hyper-Zagreb indices of graphs and its applications

The first and second Hyper-Zagreb index of a connected graph $G$ is defined by $HM_{1}(G)=\sum_{uv \in E(G)}[d(u)+d(v)]^{2}$ and $HM_{2}(G)=\sum_{uv \in E(G)}[d(u).d(v)]^{2}$. In this paper, the first and second Hyper-Zagreb indices of certain graphs are computed. Also the bounds for the first and second Hyper-Zagreb indices are determined. Further linear regression analysis of the degree based indices with the boiling points of benzenoid hydrocarbons is carried out. The linear model, based on the Hyper-Zagreb index, is better than the models corresponding to the other distance based indices

A REVIEW ON PATIENT-CONTROLLED ANALGESIA INFUSION SYSTEM

PCA is a patient-controlled analgesia infusion pump, which is used to infuse the medicine into the patients after surgery. It contains a syringe with pain medicine to infuse that is prescribed by the physician. The drugs used for pain control are high-alert medicines, since overmedication may cause death to the patients. These types of unbearable events may happen due to medical errors, prescription errors, adverse events (AEs), etc. Hence, it requires a precautionary attention or continuous monitoring for PCA pump infusion patients. However, always physicians or nurses may not monitor a patient continuously. To provide safety to the patient, the PCA pump needs a smart care process to alert the physician. This study represents the survey on PCA pump errors, AEs, and solutions for it to avoid them. The solution will automatically alert the infusion-related situation of the patients, those are taking the intravenous drug infusion at different procedure rooms in the hospitals. Moreover, it increases the safety to infusion pump with advances of decision-making in health, patient monitoring, alert notification to nursing, and productivity. This quality care can be achieved by integrating the PCA pump with other intelligent systems. Â

The Pattern of Seasonal Sediment Transport Mechanisms Around Arichaimunai by Sediment Trend Matrix (STM)

Source: ICHE Conference Archive - https://mdi-de.baw.de/icheArchiv

ANTIOXIDANT ACTIVITY OF RHIZOME EXTRACTS OF COLEUS FORSKOHLII BRIQ

Objective: The present study was on the analysis of the phytochemical constituents of Coleus forskohlii which was collected from five different areas in Tamil Nadu, where it is grown for commercial purposes.Methods: C. forskohlii tubers were collected from five areas (Thiruvannamalai, Kanchipuram, Kallakuruchi, Salem, and Vandalur) of Tamil Nadu. Dried tubers were extracted with different solvents such as aqueous, ethanol, and acetone (polar) and petroleum and chloroform (non-polar). Extracts were evaluated for total phenol and flavonoid content and antioxidant activity evaluation by 1,1-diphenyl-2-picrylhydrazyl (DPPH) reduction.Results: The highest DPPH radical scavenging activity (87.6%) was observed in ethanol extract of rhizome collected from Thiruvannamalai area. Total phenol and flavonoid contents were found to be, respectively, 38.82±0.22 mg gallic acid equivalents/g and 21.34±0.32 quercetin equivalent/g.Conclusion: The study clearly indicated the antioxidative potential of different extracts of C. forskohlii and this property may be useful in the preparation of drug formulations, health tonics, and cosmetics

Drug utilization study of atopic dermatitis in a tertiary care hospital

Background: Atopic dermatitis is a chronic relapsing hypersensitivity manifestation of the skin which has shown an increasing prevalence world over. It ranges from a mild atopic itch to an unrelenting chronic eczema. Its prevalence which is on the rise necessitates a rational approach to the diagnosis and treatment.Methods: A prospective study was conducted for a period of six months and 245 prescriptions were collected after obtaining requisite permission and a proper informed consent. The data was analysed by using WHO drug use indicators.Results: Of the 245 prescriptions analysed, there was a female predominance with a female to male ratio of 1.63:1. Age group presenting more with the symptoms of atopic dermatitis was 20 to 29 years. Antihistamines were the most commonly prescribed medication (221), Emollients were present in 193 prescriptions. Topical steroids were received by 150 patients of whom 51 were prescribed as an FDC. Tacrolimus was given to 17 patients.Conclusions: It is essential to rule out helminthic infestation, scabies and seborrhoea dermatitis to make a proper diagnosis of atopic dermatitis. More generic prescribing wherever possible might help to reduce the cost per patient

General anesthesia for cesarean section in the presence of mitral stenosis associated with severe pulmonary hypertension

Rheumatic heart disease (RHD) is the most common cause of cardiac disease during pregnancy in India. A case of severe pulmonary hypertension (pulmonary arterial pressure- 98 mm Hg) secondary to mitral stenosis associated with RHD in a 28-year old woman, is described. She underwent a high risk elective cesarean section under general anesthesia at 36 weeks of gestation. The intraoperative and postoperative course was uneventful. The advantages of general anesthesia over neuraxial blockade during cesarean section are discussed in this report. The management of patients at a high risk of developing pulmonary edema and decompensated heart failure in the perioperative period has been stressed upon. A thorough understanding of the pathophysiology and complications of RHD during pregnancy and cesarean section is required for managing the disease successfully