Exploring the Importance of Mentoring for New Scholars: A Social Exchange Perspective

This exploratory study examines the importance of mentor/mentee relationships on faculty development by measuring how social exchange between new faculty members (mentees) in information systems and their former dissertation chairs (mentors) relate to how quickly the new faculty members completed their doctoral program and the number of peer reviewed publications they produced in their first six years of academic employment. In addition, this study measures how gender and ethnicity relate to the strength of the social exchange between mentors and mentees. The results show a statistically significant relationship between social ties and the number of publications new faculty obtain in their early years of academic employment. The results also indicate that mixed gender pairs have higher social exchange in this context. This study has implications for shaping doctoral education by providing insight into the importance of social ties on the development and productivity of new faculty

Pharmacomodulation of the Antimalarial Plasmodione: Synthesis of Biaryl- and N-Arylalkylamine Analogues, Antimalarial Activities and Physicochemical Properties

With the aim of increasing the structural diversity on the early antimalarial drug plasmodione, an efficient and versatile procedure to prepare a series of biaryl- and N-arylalkylamines as plasmodione analogues is described. Using the naturally occurring and commercially available menadione as starting material, a 2-step sequence using a Kochi-Anderson reaction and subsequent Pd-catalyzed Suzuki-Miyaura coupling was developed to prepare three representative biphenyl derivatives in good yields for antimalarial evaluation. In addition, synthetic methodologies to afford 3-benzylmenadione derivatives bearing a terminal -N(Me)2 or -N(Et)2 in different positions (ortho, meta and para) on the aryl ring of the benzylic chain of plasmodione were investigated through reductive amination was used as the optimal route to prepare these protonable N-arylalkylamine privileged scaffolds. The antimalarial activities were evaluated and discussed in light of their physicochemical properties. Among the newly synthesized compounds, the para-position of the substituent remains the most favourable position on the benzyl chain and the carbamate -NHBoc was found active both in vitro (42 nM versus 29 nM for plasmodione) and in vivo in Plasmodium berghei-infected mice. The measured acido-basic features of these new molecules support the cytosol-food vacuole shuttling properties of non-protonable plasmodione derivatives essential for redox-cycling. These findings may be useful in antimalarial drug optimization

Preparation of heteroaryl and aryl pyridazine derivatives by organometallic

Les hétérocycles aromatiques sont des motifs structuraux rencontrés dans un grand nombre de substances d'intérêts biologiques ou pharmacologiques. Plus particulièrement, les pyridazines substituées font l'objet d'un intérêt grandissant pour leurs propriétés pharmaceutiques (antibactériens, anti-inflammatoires, médicaments cardiovasculaires…). De plus, les structures comportant des pyridazines peuvent également être utilisées en tant qu'agents chélatants de cations métalliques et s'ordonner en édifices utilisés en chimie supramoléculaire.Nous nous sommes donc intéressés à l'élaboration d'éléments de base comportant des cycles pyridaziniques de type aryl ou hétéroarylpyridazines. La mise au point de méthodes impliquant des espèces organométalliques a été l'un de nos objectifs primordial. L'élaboration de ces composés a été réalisée par formation de liaisons C-C. Une approche électrochimique d'hétérocouplage associé à une catalyse au nickel a été utilisée. Quelques limites à cette méthode ont cependant été observées dans le cas des couplages mettant en jeu des 3,6-dihalogénopyridazines. Une étude par électrochimie analytique a permis d'en comprendre les raisons. La seconde partie de notre travail a consisté en l'étude de la réactivité d'arylzinciques ou de triarylbismuths vis-à-vis de 3,6-dihalogénopyridazinesHeteroaromatic rings are present in various biological and pharmacological active molecules. Substituted aryl-pyridazines have given rise to considerable interest because of their diverse pharmacological properties (antibacterial, anti-inflammatory, cardiovascular drugs…). Moreover, structures which contain pyridazines are used in supramolecular chemistry for their applications through self-assembly processes in the presence of metal ions.In order to elaborate building blocks containing pyridazine rings such as aryl or heteroaryl-pyridazines, we turned our intention on the development of complementary methods involving organometallic reagents. Transition metal-catalyzed cross-coupling reaction of organometallic compounds with organic halides is one of the most powerful methods for the generation of C-C bonds.We chose to develop the most straightforward method involves heterocoupling reaction of aryl/heteroaryl compounds under electrochemical conditions (sacrificial anode process) associated to a nickel catalysis. However some limitations have been pointed out when 3,6-dihalogenopyridazines are involved in the cross-coupling reaction. An electrochemical study was investigated in order to propose some mechanistic considerations. A second part of this work consisted in the study of arylzinc and triarylbismuths reagents toward 3,6-dihalogenopyridazine

Quality Risk Management in Blood Donation Establishment

Le sujet de ce mémoire est de comprendre ce qu’est la gestion des risques dans la qualité appliqué au milieu médical. Le milieu de la transfusion sanguine n’est pas un sujet abordé dans notre société. Mais faut-il pour autant ne pas savoir comment tout cela est contrôle, normaliser. Suite aux scandales liés au sang contaminé et aux virus de plus en plus présent ce mémoire traitera des risques qualités au sein des établissements de l’EFS en France et de SBDC en Lettonie. En quoi la gestion de la qualité est-elle nécessaire dans les établissements du don du sang ? Dans la 1ère partie nous verrons qu’est-ce que le contrôle de la qualité et son importance. Au niveau de l’information donné aux donneurs, mais aussi du matériel utiliser. Dans la 2nd partie nous verrons les différentes techniques utiliser dans le contrôle du risque de la qualité en général en faisant l’attelage de plusieurs techniques utilisées dans divers établissement que ce soit dans le milieu médical ou non. Certaine des techniques qui seront expliqué ont été utilisées et seront décrire dans cette partie Dans la 3ème et dernière partie nous verrons comment l’EFS manage le risque aux seins de ses établissements. Mais aussi comment la Lettonie vie-t-elle le management du risque qualité dans ses établissement. Et un point de vue du don du sang en europe sera abordé. Ce mémoire a été écris car bien que qu’étant un produit de consommation le sang reste encore aujourd’hui un sujet « tabou » Mots clés : Don du sang, Etablissement, Produit Labile, Qualité, Management.The subject of this thesis is to understand what risk management in the quality applied to the medical community. The professional world related to blood transfusion is not a topic discussed in our society. But does this mean they do not know how it is controlled, standardized. Following the scandals linked to contaminated blood we’ll following the risks qualities risks process within institutions of EFS in France and Latvia SBDC. Why quality management must be in blood donation establishments? In the first part we will see what the quality control and its importance. Importance of information, the donors, but also the equipment used. In the 2nd part we will see the different techniques used in the quality by several techniques used in various institutions both in the medical field or not. Some techniques that have been used will be explained and will describe in this section In the third and final part we will see how EFS manage the quality risk. How Latvia take care of the quality risk management in its own establishment. And a point of view of blood donation in Europe will be discussed. This memory has been written as well as being a blood product consumption still remains a "taboo" Keywords: Blood donation, Establishment, Labile Product, Quality Management

Préparation de dérivés aryl- et hétéroaryl- pyridazine(s) par voies organométalliques chimiques ou électrochimiques

Les hétérocycles aromatiques sont des motifs structuraux rencontrés dans un grand nombre de substances d'intérêts biologiques ou pharmacologiques. Plus particulièrement, les pyridazines substituées font l'objet d'un intérêt grandissant pour leurs propriétés pharmaceutiques (antibactériens, anti-inflammatoires, médicaments cardiovasculaires ). De plus, les structures comportant des pyridazines peuvent également être utilisées en tant qu'agents chélatants de cations métalliques et s'ordonner en édifices utilisés en chimie supramoléculaire.Nous nous sommes donc intéressés à l'élaboration d'éléments de base comportant des cycles pyridaziniques de type aryl ou hétéroarylpyridazines. La mise au point de méthodes impliquant des espèces organométalliques a été l'un de nos objectifs primordial. L'élaboration de ces composés a été réalisée par formation de liaisons C-C. Une approche électrochimique d'hétérocouplage associé à une catalyse au nickel a été utilisée. Quelques limites à cette méthode ont cependant été observées dans le cas des couplages mettant en jeu des 3,6-dihalogénopyridazines. Une étude par électrochimie analytique a permis d'en comprendre les raisons. La seconde partie de notre travail a consisté en l'étude de la réactivité d'arylzinciques ou de triarylbismuths vis-à-vis de 3,6-dihalogénopyridazinesHeteroaromatic rings are present in various biological and pharmacological active molecules. Substituted aryl-pyridazines have given rise to considerable interest because of their diverse pharmacological properties (antibacterial, anti-inflammatory, cardiovascular drugs ). Moreover, structures which contain pyridazines are used in supramolecular chemistry for their applications through self-assembly processes in the presence of metal ions. In order to elaborate building blocks containing pyridazine rings such as aryl or heteroaryl-pyridazines, we turned our intention on the development of complementary methods involving organometallic reagents. Transition metal-catalyzed cross-coupling reaction of organometallic compounds with organic halides is one of the most powerful methods for the generation of C-C bonds.We chose to develop the most straightforward method involves heterocoupling reaction of aryl/heteroaryl compounds under electrochemical conditions (sacrificial anode process) associated to a nickel catalysis. However some limitations have been pointed out when 3,6-dihalogenopyridazines are involved in the cross-coupling reaction. An electrochemical study was investigated in order to propose some mechanistic considerations. A second part of this work consisted in the study of arylzinc and triarylbismuths reagents toward 3,6-dihalogenopyridazinesPARIS-EST-Université (770839901) / SudocSudocFranceF

Some mechanistic aspects of a nickel-catalyzed electrochemical cross-coupling between aryl halides and substituted chloropyridazines

The nickel-2,2'-bipyridine catalyzed electrochemical cross-coupling reaction between an aryl halide and a chloropyridazine was investigated by an electrochemical study The electrochemical behavior of the divalent nickel complex is affected by the presence of pyridazine rings which act as co-ligands of nickel Cyclic voltammetry indicates that the cross-coupling reaction involves first a rapid oxidative addition of the chloropyridazine on the electrogenerated zerovalent nickel complex. The coupling product is then obtained by reaction with the aryl halide. (C) 2010 Elsevier Ltd. All rights reserved

Pharmacomodulation of the antimalarial plasmodione: synthesis of biaryl- and N-arylalkylamine analogues, antimalarial activities and physicochemical properties

With the aim of increasing the structural diversity on the early antimalarial drug plasmodione, an efficient and versatile procedure to prepare a series of biaryl- and N-arylalkylamines as plasmodione analogues is described. Using the naturally occurring and commercially available menadione as starting material, a 2-step sequence using a Kochi-Anderson reaction and subsequent Pd-catalyzed Suzuki-Miyaura coupling was developed to prepare three representative biphenyl derivatives in good yields for antimalarial evaluation. In addition, synthetic methodologies to afford 3-benzylmenadione derivatives bearing a terminal -N(Me)2 or -N(Et)2 in different positions (ortho, meta and para) on the aryl ring of the benzylic chain of plasmodione were investigated through reductive amination was used as the optimal route to prepare these protonable N-arylalkylamine privileged scaffolds. The antimalarial activities were evaluated and discussed in light of their physicochemical properties. Among the newly synthesized compounds, the para-position of the substituent remains the most favourable position on the benzyl chain and the carbamate -NHBoc was found active both in vitro (42 nM versus 29 nM for plasmodione) and in vivo in Plasmodium berghei-infected mice. The measured acido-basic features of these new molecules support the cytosol-food vacuole shuttling properties of non-protonable plasmodione derivatives essential for redox-cycling. These findings may be useful in antimalarial drug optimization

Electrochemical coupling of mono and dihalopyridines catalyzed by nickel complex in undivided cell

International audienc

Pd-Catalyzed Chemoselective Cross-Coupling Reaction of Triaryl- or Triheteroarylbismuth Compounds with 3,6-Dihalopyridazines

International audienc