Design and evaluation of PM Ti surfaces modified by colloidal techniques and diffusion processes for biomedical applications

The aim of this work was the modification of the composition and surface microstructure of powder metallurgy titanium to improve the wear resistance and reduce the elastic modulus while maintaining the corrosion behavior, characteristics needed for biomedical applications. For this purpose, Mo and Nb coatings were produced by colloidal techniques. Stable aqueous suspensions were prepared from micro-sized powder of Mo and Nb particles, deposited onto the powder metallurgy titanium substrates (green or sintered). After a heat treatment to promote the diffusion and the consolidation of the layers, microstructural changes were obtained. In the case of green substrates, the co-sintering process provides a diffusion depth of 85-100 micron. In the as-sintered case, a uniform depth of 40-65 microns was reached. The surfaces were characterised by micro-hardness, corrosion and tribocorrosion testing, and the results showed that hardened surfaces presented lower tendency to corrosion both under static conditions and under sliding.Funds were provided by Spanish Government (programme MINECO, ref. MAT2012-38650-C02-01), Regional Government of Madrid (programme MULTIMAT-CHALLENGE, ref. S2013/MIT-2862) and Institute of Alvaro Alonso Barba (IAAB) for the research stay in CMEMS-UMINHO (University of Minho).info:eu-repo/semantics/publishedVersio

Curvaton reheating: an application to braneworld inflation

The curvaton was introduced recently as a distinct inflationary mechanism for generating adiabatic density perturbations. Implicit in that scenario is that the curvaton offers a new mechanism for reheating after inflation, as it is a form of energy density not diluted by the inflationary expansion. We consider curvaton reheating in the context of a braneworld inflation model, {\em steep inflation}, which features a novel use of the braneworld to give a new mechanism for ending inflation. The original steep inflation model featured reheating by gravitational particle production, but the inefficiency of that process brings observational difficulties. We demonstrate here that the phenomenology of steep inflation is much improved by curvaton reheating.Comment: 8 pages RevTeX4 file with two figures incorporated. Improved referencing, matches PRD accepted versio

Galactic Collapse of Scalar Field Dark Matter

We present a scenario for galaxy formation based on the hypothesis of scalar field dark matter. We interpret galaxy formation through the collapse of a scalar field fluctuation. We find that a cosh potential for the self-interaction of the scalar field provides a reasonable scenario for galactic formation, which is in agreement with cosmological observations and phenomenological studies in galaxies.Comment: 4 pages, 3 figue

Oscillatons revisited

In this paper, we study some interesting properties of a spherically symmetric oscillating soliton star made of a real time-dependent scalar field which is called an oscillaton. The known final configuration of an oscillaton consists of a stationary stage in which the scalar field and the metric coefficients oscillate in time if the scalar potential is quadratic. The differential equations that arise in the simplest approximation, that of coherent scalar oscillations, are presented for a quadratic scalar potential. This allows us to take a closer look at the interesting properties of these oscillating objects. The leading terms of the solutions considering a quartic and a cosh scalar potentials are worked in the so called stationary limit procedure. This procedure reveals the form in which oscillatons and boson stars may be related and useful information about oscillatons is obtained from the known results of boson stars. Oscillatons could compete with boson stars as interesting astrophysical objects, since they would be predicted by scalar field dark matter models.Comment: 10 pages REVTeX, 10 eps figures. Updated files to match version published in Classical and Quantum Gravit

A new cosmological tracker solution for Quintessence

In this paper we propose a quintessence model with the potential $V(\Phi )=V_{o}[ \sinh {(\alpha \sqrt{\kappa_{o}}\Delta \Phi})] ^{\beta}$, which asymptotic behavior corresponds to an inverse power-law potential at early times and to an exponential one at late times. We demonstrate that this is a tracker solution and that it could have driven the Universe into its current inflationary stage. The exact solutions and the description for a complete evolution of the Universe are also given. We compare such model with the current cosmological observations.Comment: 13 pages REVTeX, 5 eps color figure

Dark energy and dark matter from an inhomogeneous dilaton

A cosmological scenario is proposed where the dark matter (DM) and dark energy (DE) of the universe are two simultaneous manifestations of an inhomogenous dilaton. The equation of state of the field is scale-dependent and pressureless at galactic and larger scales and it has negative pressure as a DE at very large scales. The dilaton drives an inflationary phase followed by a kinetic energy-dominated one, as in the "quintessential inflation" model introduced by Peebles & Vilenkin, and soon after the end of inflation particle production seeds the first inhomogeneities that lead to galaxy formation. The dilaton is trapped near the minimum of the potential where it oscillates like a massive field, and the excess of kinetic energy is dissipated via the mechanism of "gravitational cooling" first introduced by Seidel & Suen. The inhomogeneities therefore behave like solitonic oscillations around the minimum of the potential, known as "oscillatons", that we propose account for most DM in galaxies. Those regions where the dilaton does not transform enough kinetic energy into reheating or carry an excess of it from regions that have cooled, evolve to the tail of the potential as DE, driving the acceleration of the universe.Comment: 9 pages, 8 figures, uses revtex, submitted PR

Multiple mutations in the nicotinic acetylcholine receptor Ccα6 gene associated with resistance to spinosad in medfly

Spinosad is an insecticide widely used for the control of insect pest species, including Mediterranean fruit fly, Ceratitis capitata. Its target site is the α6 subunit of the nicotinic acetylcholine receptors, and different mutations in this subunit confer resistance to spinosad in diverse insect species. The insect α6 gene contains 12 exons, with mutually exclusive versions of exons 3 (3a, 3b) and 8 (8a, 8b, 8c). We report here the selection of a medfly strain highly resistant to spinosad, JW-100 s, and we identify three recessive Ccα6 mutant alleles in the JW-100 s population: (i) Ccα63aQ68* containing a point mutation that generates a premature stop codon on exon 3a (3aQ68*); (ii) Ccα63aAG>AT containing a point mutation in the 5' splicing site of exon 3a (3aAG > AT); and (iii) Ccα63aQ68*-K352* that contains the mutation 3aQ68* and another point mutation on exon 10 (K352*). Though our analysis of the susceptibility to spinosad in field populations indicates that resistance has not yet evolved, a better understanding of the mechanism of action of spinosad is essential to implement sustainable management practices to avoid the development of resistance in field populations

Trametinib ameliorates aging-associated gut pathology in Drosophila females by reducing Pol III activity in intestinal stem cells

Pharmacological therapies are promising interventions to slow down aging and reduce multimorbidity in the elderly. Studies in animal models are the first step toward translation of candidate molecules into human therapies, as they aim to elucidate the molecular pathways, cellular mechanisms, and tissue pathologies involved in the anti-aging effects. Trametinib, an allosteric inhibitor of MEK within the Ras/MAPK (Ras/Mitogen-Activated Protein Kinase) pathway and currently used as an anti-cancer treatment, emerged as a geroprotector candidate because it extended lifespan in the fruit fly Drosophila melanogaster . Here, we confirm that trametinib consistently and robustly extends female lifespan, and reduces intestinal stem cell (ISC) proliferation, tumor formation, tissue dysplasia, and barrier disruption in guts in aged flies. In contrast, pro-longevity effects of trametinib are weak and inconsistent in males, and it does not influence gut homeostasis. Inhibition of the Ras/MAPK pathway specifically in ISCs is sufficient to partially recapitulate the effects of trametinib. Moreover, in ISCs, trametinib decreases the activity of the RNA polymerase III (Pol III), a conserved enzyme synthesizing transfer RNAs and other short, non-coding RNAs, and whose inhibition also extends lifespan and reduces gut pathology. Finally, we show that the pro-longevity effect of trametinib in ISCs is partially mediated by Maf1, a repressor of Pol III, suggesting a life-limiting Ras/MAPK-Maf1-Pol III axis in these cells. The mechanism of action described in this work paves the way for further studies on the anti-aging effects of trametinib in mammals and shows its potential for clinical application in humans

TOpic: rare and special cases, the real "Strange cases"

Introduction: The bladder hernia represents approximately 1-3% of all inguinal hernias, where patients aged more than 50 years have a higher incidence (10%). Many factors contribute to the development of a bladder hernia, including the presence of a urinary outlet obstruction causing chronic bladder distention, the loss of bladder tone, pericystitis, the perivesical bladder fat protrusion and the obesity

Identification of Colletotrichum species associated with anthracnose disease of coffee in Vietnam

Colletotrichum gloeosporioides, C. acutatum, C. capsici and C. boninense associated with anthracnose disease on coffee (Coffea spp.) in Vietnam were identified based on morphology and DNA analysis. Phylogenetic analysis of DNA sequences from the internal transcribed spacer region of nuclear rDNA and a portion of mitochondrial small subunit rRNA were concordant and allowed good separation of the taxa. We found several Colletotrichum isolates of unknown species and their taxonomic position remains unresolved. The majority of Vietnamese isolates belonged to C. gloeosporioides and they grouped together with the coffee berry disease (CBD) fungus, C. kahawae. However, C. kahawae could be distinguished from the Vietnamese C. gloeosporioides isolates based on ammonium tartrate utilization, growth rate and pathogenictity. C. gloeosporioides isolates were more pathogenic on detached green berries than isolates of the other species, i.e. C. acutatum, C capsici and C. boninense. Some of the C. gloeosporioides isolates produced slightly sunken lesion on green berries resembling CBD symptoms but it did not destroy the bean. We did not find any evidence of the presence of C. kahawae in Vietnam