748 research outputs found
Nuclear functions of the tyrosine kinase Src
Src is the representative member of the Src-family kinases (SFKs), a group of tyrosine kinases involved in several cellular processes. Its main function has been for long confined to the plasma membrane/cytoplasm compartment, being a myristoylated protein anchored to the cell membrane and functioning downstream to receptors, most of them lacking intrinsic kinase activity. In the last decades, new roles for some SFKs have been described in the nuclear compartment, suggesting that these proteins can also be involved in directly regulating gene transcription or nucleoskeleton architecture. In this review, we focused on those nuclear functions specifically attributable to Src, by considering its function as both tyrosine kinase and adapting molecule. In particular, we addressed the Src involvement in physiological as well as in pathological conditions, especially in tumors
Hydroxytyrosol and oleuropein-enriched extracts obtained from olive oil wastes and by-products as active antioxidant ingredients for poly (Vinyl alcohol)-based films
Oxidative stability of food is one of the most important parameters affecting integrity and consequently nutritional properties of dietary constituents. Antioxidants are widely used to avoid deterioration during transformation, packaging, and storage of food. In this paper, novel poly (vinyl alcohol) (PVA)-based films were prepared by solvent casting method adding an hydroxytyrosol-enriched extract (HTyrE) or an oleuropein-enriched extract (OleE) in different percentages (5, 10 and 20% w/w) and a combination of both at 5% w/w. Both extracts were obtained from olive oil wastes and by-products using a sustainable process based on membrane technologies. Qualitative and quantitative analysis of each sample carried out by high performance liquid chromatography (HPLC) and nuclear resonance magnetic spectroscopy (NMR) proved that the main components were hydroxytyrosol (HTyr) and oleuropein (Ole), respectively, two well-known antioxidant bioactive compounds found in Olea europaea L. All novel formulations were characterized investigating their morphological, optical and antioxidant properties. The promising performances suggest a potential use in active food packaging to preserve oxidative-sensitive food products. Moreover, this research represents a valuable example of reuse and valorization of agro-industrial wastes and by-products according to the circular economy model
Spectroscopy of Li-9 (Lambda) by Electroproduction
Background: In the absence of accurate data on the free two-body hyperon-nucleon interaction, the spectra of hypernuclei provides information on the details of the effective hyperon-nucleon interaction.
Purpose: To obtain a high-resolution binding-energy spectrum for the 9Be(e, e\u27 K+)9ΛLi reaction.
Method: Electroproduction of the hypernucleus 9ΛLi has been studied for the first time with sub-MeV energy resolution in Hall A at Jefferson Lab on a 9Be target. In order to increase the counting rate and to provide unambiguous kaon identification, two superconducting septum magnets and a ring imaging Cherenkov detector were added to the Hall A standard equipment.
Results: The cross section to low-lying states of 9ΛLi is concentrated within 3 MeV of the ground state and can be fit with four peaks. The positions of the doublets agree with theory while a disagreement could exist with respect to the relative strengths of the peaks in the doublets. The Λ separation energy, BΛ, of 8.36 ± 0.08 (stat.) ± 0.08 (syst.) MeV was measured, in agreement with an earlier experiment
Update of High Resolution (e,e'K^+) Hypernuclear Spectroscopy at Jefferson Lab's Hall A
Updated results of the experiment E94-107 hypernuclear spectroscopy in Hall A
of the Thomas Jefferson National Accelerator Facility (Jefferson Lab), are
presented. The experiment provides high resolution spectra of excitation energy
for 12B_\Lambda, 16N_\Lambda, and 9Li_\Lambda hypernuclei obtained by
electroproduction of strangeness. A new theoretical calculation for
12B_\Lambda, final results for 16N_\Lambda, and discussion of the preliminary
results of 9Li_\Lambda are reported.Comment: 8 pages, 5 figures, submitted to the proceedings of Hyp-X Conferenc
Performance of the Two Aerogel Cherenkov Detectors of the JLab Hall A Hadron Spectrometer
We report on the design and commissioning of two silica aerogel Cherenkov
detectors with different refractive indices. In particular, extraordinary
performance in terms of the number of detected photoelectrons was achieved
through an appropriate choice of PMT type and reflector, along with some design
considerations. After four years of operation, the number of detected
photoelectrons was found to be noticeably reduced in both detectors as a result
of contamination, yellowing, of the aerogel material. Along with the details of
the set-up, we illustrate the characteristics of the detectors during different
time periods and the probable causes of the contamination. In particular we
show that the replacement of the contaminated aerogel and parts of the
reflecting material has almost restored the initial performance of the
detectors.Comment: 18 pages, 9 Figures, 4 Tables, 44 Reference
Are standard cell culture conditions adequate for human umbilical cord blood mesenchymal stem cells?
The Impact of Functional Bars and Adapted Physical Activity on Quality of Life in Chronic Kidney Disease: A Pilot Study
Chronic kidney disease (CKD) represents a public health problem because it is characterized by several comorbidities, including uremic sarcopenia (US), and a poor quality of life. Currently, there are no standardized treatments available to counteract the onset of US but only some possible therapeutic approaches to slow its progression. The aim of this pilot study is to collect descriptive data in order to design a clinical trial based on the power analysis and simple size. The purpose of this pilot study was to evaluate the possible beneficial action induced by the functional anti-inflammatory and antioxidant bars in combination with the adapted physical activity (APA), on the onset and progression of US and other related-CKD comorbidities. We enrolled 21 CKD patients under conservative therapy, divided into four groups: (A) the physical exercise program (PEP), three times a week, in combination with the daily consumption of the two functional bars group; (B) the PEP group; (C) the daily consumption of the two functional bars group; (D) the control group. The duration of the study protocol was 12 weeks. We observed an improvement trend of body composition, blood pressure levels, lipid metabolism, and functional test in A and B groups. These preliminary data would seem to confirm the effectiveness of APA and to demonstrate the additive role of the natural bioactive compound’s assumption in countering US and other CKD comorbidities
A RICH detector for strangeness physics in Hall A at Jefferson Lab
The high-resolution hypernuclear spectroscopy experiment at Jefferson Lab, Hall A (E94-107), needs unambiguous kaon identification. Due to the huge pion and proton background, the standard Hall A hadron particle identification, based on a time of flight and two aerogel threshold Cherenkov detectors, is not sufficient. For this task a proximity focusing C6F14/CsI RICH has been built. Recently, after some improvements to the mechanical structure of its wire chamber and to its electronics rate capability, the RICH has been tested with cosmic rays. This paper represents a status report of the RICH detector
The HERMES Dual-Radiator Ring Imaging Cerenkov Detector
The construction and use of a dual radiator Ring Imaging Cerenkov(RICH)
detector is described. This instrument was developed for the HERMES experiment
at DESY which emphasizes measurements of semi-inclusive deep-inelastic
scattering. It provides particle identification for pions, kaons, and protons
in the momentum range from 2 to 15 GeV, which is essential to these studies.
The instrument uses two radiators, C4F10, a heavy fluorocarbon gas, and a wall
of silica aerogel tiles. The use of aerogel in a RICH detector has only
recently become possible with the development of clear, large homogeneous and
hydrophobic aerogel. A lightweight mirror was constructed using a newly
perfected technique to make resin-coated carbon-fiber surfaces of optical
quality. The photon detector consists of 1934 photomultiplier tubes for each
detector half, held in a soft steel matrix to provide shielding against the
residual field of the main spectrometer magnet.Comment: 25 pages, 23 figure
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