203 research outputs found
Shields and Kirpans: How RFRA Promotes Irrational-Basis Review as for-Profit Companies Challenge the Affordable Care Act\u27s Women\u27s Health Amendment
Working the Borderlands, Becoming \u3cem\u3eMestiza\u3c/em\u3e: An Interview with Gloria Anzaldúa
The Effect of Coherent Structures on Stochastic Acceleration in MHD Turbulence
We investigate the influence of coherent structures on particle acceleration
in the strongly turbulent solar corona. By randomizing the Fourier phases of a
pseudo-spectral simulation of isotropic MHD turbulence (Re ), and
tracing collisionless test protons in both the exact-MHD and phase-randomized
fields, it is found that the phase correlations enhance the acceleration
efficiency during the first adiabatic stage of the acceleration process. The
underlying physical mechanism is identified as the dynamical MHD alignment of
the magnetic field with the electric current, which favours parallel
(resistive) electric fields responsible for initial injection. Conversely, the
alignment of the magnetic field with the bulk velocity weakens the acceleration
by convective electric fields - \bfu \times \bfb at a non-adiabatic stage of
the acceleration process. We point out that non-physical parallel electric
fields in random-phase turbulence proxies lead to artificial acceleration, and
that the dynamical MHD alignment can be taken into account on the level of the
joint two-point function of the magnetic and electric fields, and is therefore
amenable to Fokker-Planck descriptions of stochastic acceleration.Comment: accepted for publication in Ap
Recognising the need for innovation in digitalising urgent or advance care planning in adults aged 70 years and over following emergency admission.
Forbush decreases and solar events seen in the 10 - 20GeV energy range by the Karlsruhe Muon Telescope
Since 1993, a muon telescope located at Forschungszentrum Karlsruhe
(Karlsruhe Muon Telescope) has been recording the flux of single muons mostly
originating from primary cosmic-ray protons with dominant energies in the 10 -
20 GeV range. The data are used to investigate the influence of solar effects
on the flux of cosmic-rays measured at Earth. Non-periodic events like Forbush
decreases and ground level enhancements are detected in the registered muon
flux. A selection of recent events will be presented and compared to data from
the Jungfraujoch neutron monitor. The data of the Karlsruhe Muon Telescope help
to extend the knowledge about Forbush decreases and ground level enhancements
to energies beyond the neutron monitor regime.Comment: 9 pages, 7 figures, in Press AS
A novel application of capnography during controlled human exposure to air pollution
BACKGROUND: The objective was to determine the repeatability and stability of capnography interfaced with human exposure facility. METHODS: Capnographic wave signals were obtained from five healthy volunteers exposed to particle-free, filtered air during two consecutive 5 min intervals, 10 min apart, within the open and then the sealed and operational human exposure facility (HEF). Using a customized setup comprised of the Oridion Microcap(® )portable capnograph, DA converter and AD card, the signal was acquired and saved as an ASCII file for subsequent processing. The minute ventilation (VE), respiratory rate (RR) and expiratory tidal volume (V(TE)) were recorded before and after capnographic recording and then averaged. Each capnographic tracing was analyzed for acceptable waves. From each recorded interval, 8 to 19 acceptable waves were selected and measured. The following wave parameters were obtained: total length and length of phase II and III, slope of phase II and III, area under the curve and area under phase III. In addition, we recorded signal measures including the mean, standard deviation, mode, minimum, maximum – which equals end-tidal CO(2 )(EtCO(2)), zero-corrected maximum and true RMS. RESULTS: Statistical analysis using a paired t-test for means showed no statistically significant changes of any wave parameters and wave signal measures, corrected for RR and V(TE), comparing the measures when the HEF was open vs. sealed and operational. The coefficients of variation of the zero-corrected and uncorrected EtCO(2), phase II absolute difference, signal mean, standard deviation and RMS were less than 10% despite a sub-atmospheric barometric pressure, and slightly higher temperature and relative humidity within the HEF when operational. CONCLUSION: We showed that a customized setup for the acquisition and processing of the capnographic wave signal, interfaced with HEF was stable and repeatable. Thus, we expect that analysis of capnographic waves in controlled human air pollution exposure studies is a feasible tool for characterization of cardio-pulmonary effects of such exposures
Diffusion and drift of cosmic rays in highly turbulent magnetic fields
We determine numerically the parallel, perpendicular, and antisymmetric
diffusion coefficients for charged particles propagating in highly turbulent
magnetic fields, by means of extensive Monte Carlo simulations. We propose
simple expressions, given in terms of a small set of fitting parameters, to
account for the diffusion coefficients as functions of magnetic rigidity and
turbulence level, and corresponding to different kinds of turbulence spectra.
The results obtained satisfy scaling relations, which make them useful for
describing the cosmic ray origin and transport in a variety of different
astrophysical environments.Comment: 17 pages, 7 figure
Combustion-derived nanoparticulate induces the adverse vascular effects of diesel exhaust inhalation
Traffic-related air pollution and respiratory symptoms among asthmatic children, resident in Mexico City: the EVA cohort study
<p>Abstract</p> <p>Background</p> <p>Taffic-related air pollution has been related to adverse respiratory outcomes; however, there is still uncertainty concerning the type of vehicle emission causing most deleterious effects.</p> <p>Methods</p> <p>A panel study was conducted among 147 asthmatic and 50 healthy children, who were followed up for an average of 22 weeks. Incidence density of coughing, wheezing and breathing difficulty was assessed by referring to daily records of symptoms and child's medication. The association between exposure to pollutants and occurrence of symptoms was evaluated using mixed-effect models with binary response and poisson regression.</p> <p>Results</p> <p>Wheezing was found to relate significantly to air pollutants: an increase of 17.4 μg/m<sup>3 </sup>(IQR) of PM<sub>2.5 </sub>(24-h average) was associated with an 8.8% increase (95% CI: 2.4% to 15.5%); an increase of 34 ppb (IQR) of NO<sub>2 </sub>(1-h maximum) was associated with an 9.1% increase (95% CI: 2.3% to16.4%) and an increase of 48 ppb (IQR) in O<sub>3 </sub>levels (1 hr maximum) to an increase of 10% (95% CI: 3.2% to 17.3%). Diesel-fueled motor vehicles were significantly associated with wheezing and bronchodilator use (IRR = 1.29; 95% CI: 1.03 to 1.62, and IRR = 1.32; 95% CI: 0.99 to 1.77, respectively, for an increase of 130 vehicles hourly, above the 24-hour average).</p> <p>Conclusion</p> <p>Respiratory symptoms in asthmatic children were significantly associated with exposure to traffic exhaust, especially from natural gas and diesel-fueled vehicles.</p
Augmentation of arginase 1 expression by exposure to air pollution exacerbates the airways hyperresponsiveness in murine models of asthma
Abstract
Background
Arginase overexpression contributes to airways hyperresponsiveness (AHR) in asthma. Arginase expression is further augmented in cigarette smoking asthmatics, suggesting that it may be upregulated by environmental pollution. Thus, we hypothesize that arginase contributes to the exacerbation of respiratory symptoms following exposure to air pollution, and that pharmacologic inhibition of arginase would abrogate the pollution-induced AHR.
Methods
To investigate the role of arginase in the air pollution-induced exacerbation of airways responsiveness, we employed two murine models of allergic airways inflammation. Mice were sensitized to ovalbumin (OVA) and challenged with nebulized PBS (OVA/PBS) or OVA (OVA/OVA) for three consecutive days (sub-acute model) or 12 weeks (chronic model), which exhibit inflammatory cell influx and remodeling/AHR, respectively. Twenty-four hours after the final challenge, mice were exposed to concentrated ambient fine particles plus ozone (CAP+O3), or HEPA-filtered air (FA), for 4 hours. After the CAP+O3 exposures, mice underwent tracheal cannulation and were treated with an aerosolized arginase inhibitor (S-boronoethyl-L-cysteine; BEC) or vehicle, immediately before determination of respiratory function and methacholine-responsiveness using the flexiVent®. Lungs were then collected for comparison of arginase activity, protein expression, and immunohistochemical localization.
Results
Compared to FA, arginase activity was significantly augmented in the lungs of CAP+O3-exposed OVA/OVA mice in both the sub-acute and chronic models. Western blotting and immunohistochemical staining revealed that the increased activity was due to arginase 1 expression in the area surrounding the airways in both models. Arginase inhibition significantly reduced the CAP+O3-induced increase in AHR in both models.
Conclusions
This study demonstrates that arginase is upregulated following environmental exposures in murine models of asthma, and contributes to the pollution-induced exacerbation of airways responsiveness. Thus arginase may be a therapeutic target to protect susceptible populations against the adverse health effects of air pollution, such as fine particles and ozone, which are two of the major contributors to smog
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