A Mixed-Methods Exploration of Intentional Self Regulation and Youth Beliefs about the Chances of Achieving Future Aspirations

Using a mixed methods approach, the connection between Intentional Self Regulation (ISR) and feelings about the chances of achieving future aspirations among 94 Scottish youth (56% female) was examined. Regression analyses demonstrated ISR, as measured by the SOC 9-item scale, was predictive of youths’ feelings about their chances of achieving future aspirations. Qualitative data collected from 26 interviews suggested the use of ISR skills among adolescents, even when those skills were not evident quantitatively. Results indicated the need to employ mixed methodologies when conducting research on ISR with young adolescents, and suggest the need for further testing and development of measures for both ISR and beliefs about the chances of achieving future aspirations. Potential programmatic implications for youth development and character education programs are also discussed

Using Cognitive Interviewing to Test Youth Survey and Interview Items in Evaluation: A Case Example

Background: Cognitive interviewing is a pretesting tool used by evaluators to increase item and response option validity. Cognitive interviewing techniques are used to assess the cognitive processes utilized by participants to respond to items. This approach is particularly appropriate for testing items with children and adolescents who have more limited cognitive capacities than adults, vary in their cognitive development, and have a unique perspective on their life experiences and context. Purpose: This paper presents a case example of cognitive interviewing with youth as part of a national program evaluation, and aims to expand the use of cognitive interviewing as a pretesting tool for both quantitative and qualitative items in evaluation studies involving youth. Setting: Youth participants were located in four regions of the United States: Northeast, Central, Southern, and Western. Interviewers were located at Montclair State University. Intervention: Not applicable. Research design: A cognitive interview measure was designed to include a subset of survey items, interview questions, and verbal probes, to evaluate if these items and questions would be understood as intended by both younger and older youth participants. An iterative design was used with cognitive interviewing testing rounds, analysis, and revisions. Data Collection and Analysis: The cognitive interview was administered by phone to 10 male youth, five from the 10-13-year-old age range and five from the 15-17-year-old age range. Interviews were audio-recorded, transcribed, reviewed, and coded. Survey items and interview questions were revised based on feedback from the participants and consensus agreement among the evaluation team. Item revisions were included in further testing rounds with new participants. Findings: As a result of using cognitive interviewing to pretest survey and interview items with youth, response errors were identified. Participants did not understand some of the items and response options as intended, indicating problems with validity. These findings support the use of cognitive interviewing for testing and modifying survey items adapted for use with youth, as well as qualitative interview items. Additionally, the perspective of the youth participants was valuable for informing decisions to modify items and helping the evaluators learn the participants’ program culture and experiences. Based on the findings and limitations of the study, we give practice recommendations for future studies using cognitive interviewing with a youth sample. Keywords: cognitive interviewing; item validity; response error; verbal probes; pre-testing surveys; qualitative evaluation; interviewing children and adolescents; survey developmen

Intentional Self Regulation and Positive Youth Development: Implications for Youth Development Programs

Character education programs are mission-aligned with the positive youth development (PYD) perspective, which, in research with American youth suggests that intentional self-regulation (ISR) develops through mutually beneficial interactions between youth and their environment. Cross-cultural studies of Western youth suggest an adolescence-specific ISR process may exist. We begin to extend this work to assess the relationship between ISR and positive development in young Scottish adolescents (approximately 7th grade, N = 82; 50% male), a previously unexamined group. ISR was correlated with the Five Cs of PYD and OLS regression analyses demonstrated that ISR predicted two of the Five Cs: Character and Connection. We discuss implications for youth development programs of the findings that ISR and some indices of PYD were linked in a sample of Scottish youth

Pink verrucous plaque in a man with systemic mastocytosis

Porokeratosis ptychotropica is a rare and commonly misdiagnosed subtype of porokeratosis involving the body folds. We present a 53-year-old man with systemic mastocytosis who presented with a pruritic, verrucous plaque in the gluteal fold that showed multiple cornoid lamellae on histopathologic evaluation, diagnostic of porokeratosis ptychotropica. Various treatments have been reported, including topical corticosteroids, retinoids, vitamin D analogs, calcineurin inhibitors, imiquimod, phototherapy, cryotherapy, or ablative laser therapy, but recurrences are common

Solving the Orphan Works Problem for the United States

Over the last decade, the problem of orphan works—i.e., copyrighted works whose owners cannot be located by a reasonably diligent search—has come sharply into focus as libraries, archives and other large repositories of copyrighted works have sought to digitize and make available their collections online. Combined with new technology that has changed the way that copyrighted works are created and the way that consumers expect to access and use copyrighted works, the orphan works problem has grown into a significant and, as former Register of Copyrights Marybeth Peters observed, a “pervasive” problem. Although this problem is certainly not limited to digital libraries, it has proven especially challenging for these organizations because they hold diverse collections that include millions of books, articles, letters, photographs, home movies, films and other types of works. Many items come with a complex, unknown and often unknowable history of copyright ownership. Because U.S. copyright law provides for both strong injunctive relief and monetary damages (in the form of statutory damages of up to $150,000 per work infringed), organizations that cannot obtain permission often do not make their collections available at all. Large projects, such as Google Book Search and the HathiTrust digital library, which aim in part to address orphan works on a larger scale, have been drawn into litigation

On the Correlations between Flavour Observables in Minimal U(2)^3 Models

The stringent correlations between flavour observables in models with CMFV are consistent with the present data except for the correlation Delta M_{s,d}-epsilon_K. Motivated by the recent work of Barbieri et al, we compare the CMFV correlations with the ones present in a special class of models with an approximate global U(2)^3 flavour symmetry, constrained by a minimal set of spurions governing the breakdown of this symmetry and the assumption that only SM operators are relevant in flavour physics. This analog of CMFV to be called MU(2)^3 allows to avoid the Delta M_{s,d}-epsilon_K tension in question because of reduced flavour symmetry and implied non-MFV contributions to Delta M_{s,d}. While the patterns of flavour violation in K meson system is the same as in CMFV models, the CP-violation in B_{s,d} meson systems can deviate from the one in the SM and CMFV models. We point out a stringent triple S_{psi K_S}-S_{psi phi}-|V_ub| correlation in this class of models that could in the future provide a transparent distinction between different MU(2)^3 models and in the context of these models determine |V_ub| by means of precise measurements of S_{psi K_S} and S_{psi phi} with only small hadronic uncertainties. For fixed S_{psi K_S} the correlation between B(B^+ -> tau^+nu_tau) and S_{psi phi} follows. We also find that MU(2)^3 models could in principle accommodate a negative value of S_{psi phi}, provided |V_ub| is found to be in the ballpark of exclusive determinations and the particular MU(2)^3 model provides a 25% enhancement of epsilon_K. A supersymmetric U(2)^3 model worked out in the Barbieri-School appears to satisfy these requirements. However if B(B^+ -> tau^+nu_tau)>1.0 10^{-4} will be confirmed by future experiments only positive S_{psi phi} is allowed in this framework. We summarize briefly the pattern of flavour violation in rare K and B_{s,d} decays in MU(2)^3 models.Comment: 28 pages, 6 figures; v2: Few references and discussion on CP violation in B_s-> mu^+ mu^- added; v3: Several clarifying comments added, conclusions unchanged, version accepted for publication in JHE

Capacitating Community: The Writing Innovation Symposium

The topic of this symposium, capacitating community, invites CLJ readers to consider what makes a community possible. This piece showcases one means, small conferences, via a retrospective on the Writing Innovation Symposium (WIS), a regional event with national scope that has hosted writers and writing educators annually in Milwaukee, WI, since 2018. Through a quilted conversation pieced from hours of small-group discussion, twenty-nine participants across academic and nonacademic ranks, roles, and ranges of experience offer insight into the WIS as well as the nature and value of professional community

Creation of an Enhanced Recovery after Surgery (ERAS) Guideline for neonatal intestinal surgery patients: A knowledge synthesis and consensus generation approach and protocol study

Introduction: Enhanced Recovery After Surgery (ERAS) guidelines integrate evidence-based practices into multimodal care pathways designed to optimise patient recovery following surgery. The objective of this project is to create an ERAS protocol for neonatal abdominal surgery. The protocol will identify and attempt to bridge the gaps between current practices and best evidence. Our study is the first paediatric ERAS protocol endorsed by the International ERAS Society. Methods: A research team consisting of international clinical and family stakeholders as well as methodological experts have iteratively defined the scope of the protocol in addition to individual topic areas. A modified Delphi method was used to reach consensus. The second phase will include a series of knowledge syntheses involving a rapid review coupled with expert opinion. Potential protocol elements supported by synthesised evidence will be identified. The Grades of Recommendation, Assessment, Development, and Evaluation (GRADE) system will be used to determine strength of recommendations and the quality of evidence. The third phase will involve creation of the protocol using a modified RAND/UCLA Appropriateness Method. Group consensus will be used to rate each element in relation to the quality of evidence supporting the recommendation and the appropriateness for guideline inclusion. This protocol will form the basis of a future implementation study. Ethics and dissemination: This study has been registered with the ERAS Society. Human ethics approval (REB 18-0579) is in place to engage patient families within protocol development. This research is to be published in peer-reviewed journals and will form the care standard for neonatal intestinal surgery

Long-Distance Delivery of Bacterial Virulence Factors by Pseudomonas aeruginosa Outer Membrane Vesicles

Bacteria use a variety of secreted virulence factors to manipulate host cells, thereby causing significant morbidity and mortality. We report a mechanism for the long-distance delivery of multiple bacterial virulence factors, simultaneously and directly into the host cell cytoplasm, thus obviating the need for direct interaction of the pathogen with the host cell to cause cytotoxicity. We show that outer membrane–derived vesicles (OMV) secreted by the opportunistic human pathogen Pseudomonas aeruginosa deliver multiple virulence factors, including β-lactamase, alkaline phosphatase, hemolytic phospholipase C, and Cif, directly into the host cytoplasm via fusion of OMV with lipid rafts in the host plasma membrane. These virulence factors enter the cytoplasm of the host cell via N-WASP–mediated actin trafficking, where they rapidly distribute to specific subcellular locations to affect host cell biology. We propose that secreted virulence factors are not released individually as naked proteins into the surrounding milieu where they may randomly contact the surface of the host cell, but instead bacterial derived OMV deliver multiple virulence factors simultaneously and directly into the host cell cytoplasm in a coordinated manner

Modifying Ligand-Induced and Constitutive Signaling of the Human 5-HT4 Receptor

G protein–coupled receptors (GPCRs) signal through a limited number of G-protein pathways and play crucial roles in many biological processes. Studies of their in vivo functions have been hampered by the molecular and functional diversity of GPCRs and the paucity of ligands with specific signaling effects. To better compare the effects of activating different G-protein signaling pathways through ligand-induced or constitutive signaling, we developed a new series of RASSLs (receptors activated solely by synthetic ligands) that activate different G-protein signaling pathways. These RASSLs are based on the human 5-HT4b receptor, a GPCR with high constitutive Gs signaling and strong ligand-induced G-protein activation of the Gs and Gs/q pathways. The first receptor in this series, 5-HT4-D100A or Rs1 (RASSL serotonin 1), is not activated by its endogenous agonist, serotonin, but is selectively activated by the small synthetic molecules GR113808, GR125487, and RO110-0235. All agonists potently induced Gs signaling, but only a few (e.g., zacopride) also induced signaling via the Gq pathway. Zacopride-induced Gq signaling was enhanced by replacing the C-terminus of Rs1 with the C-terminus of the human 5-HT2C receptor. Additional point mutations (D66A and D66N) blocked constitutive Gs signaling and lowered ligand-induced Gq signaling. Replacing the third intracellular loop of Rs1 with that of human 5-HT1A conferred ligand-mediated Gi signaling. This Gi-coupled RASSL, Rs1.3, exhibited no measurable signaling to the Gs or Gq pathway. These findings show that the signaling repertoire of Rs1 can be expanded and controlled by receptor engineering and drug selection