Big Bang-Big Crunch Algorithm for Dynamic Deployment of Wireless Sensor Network

This paper proposes soft computing technique Big Bang-Big Crunch (BB-BC) to address the main issue of deployment of wireless sensor networks. Deployment is the main factor that significantly affects the performance of the wireless sensor network. This approach maximizes the coverage area of the given set of sensors. We implemented our approach in MATLAB and compared it with ABC approach and found that the proposed approach is much better than the said approach

FPOA Implementation for WSN Energy Efficient Routing

In this paper,a soft computing technique Flower Pollination optimization Algorithm(FPOA) for WSN is proposed.The Sensor Network is heterogeneous in nature. Proposed algorithm is designed and implemented in MATLAB.In this technique some nodes send data directly to base station as local pollination and some by Multihop Routing as global pollination. A routing scheme is process which helps in minimizing the energy consumption. We implemented FPOA and compared the results with techniques that are already developed.(Low Energy adaptive clustering hierarchy (LEACH), Stable Election Protocol (SEP) and Zonal-Stable Election Protocol (Z-SEP) Simulation results show that FPOA enhance first node dead time, throughput and overall energy consumes less than existing protocols like LEACH, SEP and Z-SE

Role of Negative Pressure Wound Therapy in Healing of Diabetic Foot Ulcers

Introduction: Foot disorders such as ulceration, infection and gangrene are the most common, complex and costly sequelae of diabetes mellitus.[1-3] Even for the most superficial wounds, treatment is often difficult with poor healing responses and high rates of complications. The purpose of this study is to compare the rate of ulcer healing with the negative pressure dressing technique to conventional moist dressings in the treatment of diabetic foot ulcers. Materials and Methods: The study was conducted on 30 patients, which were divided into two groups. One group received negative pressure dressing while other group received conventional saline moistened gauze dressing. Results were compared for rate of wound healing. Results: There was a statistically significant difference in the rate of appearance of granulation tissue between the two groups; with granulation tissue appearing earlier in the study group. The study group promised a better outcome (80% complete responders) as compared to the control group (60% complete responders). Conclusions: Negative pressure wound therapy has a definitive role in healing of diabetic foot ulcers

Community-engaged primary care medical education

BACKGROUND: Community-engaged medical education (CEME) requires medical schools to partner with local communities to help address community priorities, whilst enhancing the learning experiences of students. Current literature on CEME has focused on evaluating its effects on students; however, there remains a gap in exploring whether CEME initiatives can have a sustainable impact for communities. APPROACH: The Community Action Project (CAP) at Imperial College London, is an eight-week, community-engaged, quality improvement project for Year 3 medical students. Students initially consult with clinicians, patients and wider community stakeholders to understand local needs and assets, and identify a health priority to address. They then work with relevant stakeholders to design, implement and evaluate a project to help address their identified priority. EVALUATION: All CAPs (n = 264) completed in the 2019-2021 academic years were evaluated for evidence of several key areas, including community engagement and sustainability. 91% of projects evidenced a needs analysis, 71% demonstrated patient involvement in their development, and 64% demonstrated sustainable impacts from their projects. Analysis revealed the topics frequently addressed, and the formats used by students. Two CAPs are described in more detail to demonstrate their community impact. IMPLICATIONS: The CAP demonstrates how the principles of CEME (meaningful community engagement and social accountability) can lead to sustainable benefits for local communities through purposeful collaboration with patients and local communities. Strengths, limitations and future directions are highlighted

Thermoelectric transport properties of a T-shaped double quantum dot system in the Coulomb blockade regime

We investigate the thermoelectric properties of a T-shaped double quantum dot system described by a generalized Anderson Hamiltonian. The system's electrical conduction (G) and the fundamental thermoelectric parameters such as the Seebeck coefficient ($S$) and the thermal conductivity ($\kappa$), along with the system's thermoelectric figure of merit (ZT) are numerically estimated based on a Green's function formalism that includes contributions up to the Hartree-Fock level. Our results account for finite onsite Coulomb interaction terms in both component quantum dots and discuss various ways leading to an enhanced thermoelectric figure of merit for the system. We demonstrate that the presence of Fano resonances in the Coulomb blockade regime is responsible for a strong violation of the Wiedemann-Franz law and a considerable enhancement of the system's figure of merit ($ZT$).Comment: 7 pages, 10 figure

Simultaneous analysis for Dry well and Future prospective location with the use of calibrated seismic attributes and newly generated rock property volumes -A Case Study

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ZIKV infection regulates inflammasomes pathway for replication in monocytes

© 2017 The Author(s). ZIKV causes microcephaly by crossing the placental barrier, however, the mechanism of trans-placental dissemination of ZIKV remains unknown. Here, we sought to determine whether monocytes, which can cross tissue barriers, assist ZIKV dissemination to the fetus. We determined this by infecting monocytes with two strains of ZIKV: South American (PRVABC59) and Nigerian (IBH30656) and analyzing viral replication. We found that ZIKV infects and replicates in monocytes and macrophages, which results in the modulation of a large number of cellular genes. Analysis of these genes identified multiple pathways including inflammasome to be targeted by ZIKV, which was confirmed by analyzing the transcript levels of the proteins of inflammasome pathways, NLRP3, ASC, caspase 1, IL-1 and IL-18. Interestingly, IFNα and the IFN inducible gene, MxA were not enhanced, suggesting prevention of innate antiviral defense by ZIKV. Also, inhibition of inflammasome led to an increased transcriptional activity of IFNα, MxA and CXCL10. Based on these results we suggest that ZIKV transcription is regulated by inflammasomes