200 research outputs found
CEP-stable Tunable THz-Emission Originating from Laser-Waveform-Controlled Sub-Cycle Plasma-Electron Bursts
We study THz-emission from a plasma driven by an incommensurate-frequency
two-colour laser field. A semi-classical transient electron current model is
derived from a fully quantum-mechanical description of the emission process in
terms of sub-cycle field-ionization followed by continuum-continuum electron
transitions. For the experiment, a CEP-locked laser and a near-degenerate
optical parametric amplifier are used to produce two-colour pulses that consist
of the fundamental and its near-half frequency. By choosing two incommensurate
frequencies, the frequency of the CEP-stable THz-emission can be continuously
tuned into the mid-IR range. This measured frequency dependence of the
THz-emission is found to be consistent with the semi-classical transient
electron current model, similar to the Brunel mechanism of harmonic generation
Bound-to-bound and bound-to-continuum optical transitions in combined quantum dot - superlattice systems
By combining band gap engineering with the self-organized growth of quantum
dots, we present a scheme of adjusting the mid-infrared absorption properties
to desired energy transitions in quantum dot based photodetectors. Embedding
the self organized InAs quantum dots into an AlAs/GaAs superlattice enables us
to tune the optical transition energy by changing the superlattice period as
well as by changing the growth conditions of the dots. Using a one band
envelope function framework we are able, in a fully three dimensional
calculation, to predict the photocurrent spectra of these devices as well as
their polarization properties. The calculations further predict a strong impact
of the dots on the superlattices minibands. The impact of vertical dot
alignment or misalignment on the absorption properties of this dot/superlattice
structure is investigated. The observed photocurrent spectra of vertically
coupled quantum dot stacks show very good agreement with the calculations.In
these experiments, vertically coupled quantum dot stacks show the best
performance in the desired photodetector application.Comment: 8 pages, 10 figures, submitted to PR
In response to: Anatomy of 18F-GE180, a failed radioligand for the TSPO protein
Purpose!#!Pulmonary hypertension (PH) is characterized by a progressive remodelling of the pulmonary vasculature resulting in right heart failure and eventually death. The serotonin transporter (SERT) may be involved in the pathogenesis of PH in patients with chronic-obstructive pulmonary disease (COPD). This study investigated for the first time the SERT in vivo availability in the lungs of patients with COPD and PH (COPD+PH).!##!Methods!#!SERT availability was assessed using SERT-selective [!##!Results!#![!##!Conclusion!#!By applying
Electrically Switchable Photonic Molecule Laser
We have studied the coherent intercavity coupling of the evanescent fields of
the whispering gallery modes of two terahertz quantum-cascade lasers
implemented as microdisk cavities. The electrically pumped single-mode
operating microcavities allow to electrically control the coherent mode
coupling for proximity distances of the cavities up to 30-40 \mu\m. The optical
emission of the strongest coupled photonic molecule can be perfectly switched
by the electrical modulation of only one of the coupled microdisks. The
threshold characteristics of the strongest coupled photonic molecule
demonstrates the linear dependence of the gain of a quantum-cascade laser on
the applied electric field.Comment: 4 pages, 4 figure
Intersubband gain in a Bloch oscillator and Quantum cascade laser
The link between the inversion gain of quantum cascade structures and the
Bloch gain in periodic superlattices is presented. The proposed theoretical
model based on the density matrix formalism is able to treat the gain mechanism
of the Bloch oscillator and Quantum cascade laser on the same footing by taking
into account in-plane momentum relaxation. The model predicts a dispersive
contribution in addition to the (usual) population-inversion-dependent
intersubband gain in quantum cascade structures and - in the absence of
inversion - provides the quantum mechanical description for the dispersive gain
in superlattices. It corroborates the predictions of the semi-classical
miniband picture, according to which gain is predicted for photon energies
lower than the Bloch oscillation frequency, whereas net absorption is expected
at higher photon energies, as a description which is valid in the
high-temperature limit. A red-shift of the amplified emission with respect to
the resonant transition energy results from the dispersive gain contribution in
any intersubband transition, for which the population inversion is small.Comment: 10 pages, 6 figure
Spontaneous DC Current Generation in a Resistively Shunted Semiconductor Superlattice Driven by a TeraHertz Field
We study a resistively shunted semiconductor superlattice subject to a
high-frequency electric field. Using a balance equation approach that
incorporates the influence of the electric circuit, we determine numerically a
range of amplitude and frequency of the ac field for which a dc bias and
current are generated spontaneously and show that this region is likely
accessible to current experiments. Our simulations reveal that the Bloch
frequency corresponding to the spontaneous dc bias is approximately an integer
multiple of the ac field frequency.Comment: 8 pages, Revtex, 3 Postscript figure
Longitudinal [F-18]GE-180 PET Imaging Facilitates In Vivo Monitoring of TSPO Expression in the GL261 Glioblastoma Mouse Model
The 18 kDa translocator protein (TSPO) is increasingly recognized as an interesting target for the imaging of glioblastoma (GBM). Here, we investigated TSPO PET imaging and autoradiography in the frequently used GL261 glioblastoma mouse model and aimed to generate insights into the temporal evolution of TSPO radioligand uptake in glioblastoma in a preclinical setting. We performed a longitudinal [F-18]GE-180 PET imaging study from day 4 to 14 post inoculation in the orthotopic syngeneic GL261 GBM mouse model (n = 21 GBM mice, n = 3 sham mice). Contrast-enhanced computed tomography (CT) was performed at the day of the final PET scan (+/- 1 day). [F-18] GE-180 autoradiography was performed on day 7, 11 and 14 (ex vivo: n = 13 GBM mice, n = 1 sham mouse;in vitro: n = 21 GBM mice;n = 2 sham mice). Brain sections were also used for hematoxylin and eosin (H&E) staining and TSPO immunohistochemistry. [F-18]GE-180 uptake in PET was elevated at the site of inoculation in GBM mice as compared to sham mice at day 11 and later (at day 14, TBRmax +27% compared to sham mice, p = 0.001). In GBM mice, [F-18]GE-180 uptake continuously increased over time, e.g., at day 11, mean TBRmax +16% compared to day 4, p = 0.011. [(18) F]GE-180 uptake as depicted by PET was in all mice co-localized with contrast-enhancement in CT and tissue-based findings. [F-18]GE-180 ex vivo and in vitro autoradiography showed highly congruent tracer distribution (r = 0.99, n = 13, p < 0.001). In conclusion, [F-18]GE-180 PET imaging facilitates non-invasive in vivo monitoring of TSPO expression in the GL261 GBM mouse model. [F-18]GE-180 in vitro autoradiography is a convenient surrogate for ex vivo autoradiography, allowing for straightforward identification of suitable models and scan time-points on previously generated tissue sections
Free carrier absorption in quantum cascade structures
We show that the free carrier absorption in Quantum Cascade Lasers is very
small and radically different from the classical Drude result on account of the
orthogonality between the direction of the carrier free motion and the electric
field of the laser emission. A quantum mechanical calculation of the free
carrier absorption and inter-subband oblique absorption induced by interface
defects, coulombic impurities and optical phonon absorption/emission is
presented for QCL's with a double quantum well design. The interaction between
the electrons and the optical phonons dominates at room temperature
Intrinsic response time of graphene photodetectors
Graphene-based photodetectors are promising new devices for high-speed
optoelectronic applications. However, despite recent efforts, it is not clear
what determines the ultimate speed limit of these devices. Here, we present
measurements of the intrinsic response time of metal-graphene-metal
photodetectors with monolayer graphene using an optical correlation technique
with ultrashort laser pulses. We obtain a response time of 2.1 ps that is
mainly given by the short lifetime of the photogenerated carriers. This time
translates into a bandwidth of ~262 GHz. Moreover, we investigate the
dependence of the response time on gate voltage and illumination laser power
Linear optical absorption spectra of mesoscopic structures in intense THz fields: free particle properties
We theoretically study the effect of THz radiation on the linear optical
absorption spectra of semiconductor structures. A general theoretical
framework, based on non-equilibrium Green functions, is formulated, and applied
to the calculation of linear optical absorption spectrum for several
non-equilibrium mesoscopic structures. We show that a blue-shift occurs and
sidebands appear in bulk-like structures, i.e., the dynamical Franz-Keldysh
effect [A.-P. Jauho and K. Johnsen, Phys. Rev. Lett. 76, 4576 (1996)]. An
analytic calculation leads to the prediction that in the case of superlattices
distinct stable steps appear in the absorption spectrum when conditions for
dynamical localization are met.Comment: 13 Pages, RevTex using epsf to include 8 ps figures. Submitted to
Phys. Rev. B (3 April 97
- …