Clinical evaluation of endolymphatic radiotherapy in malignant lymphoma

By endolymphatic injection of radioisotope 131I.Lipiodol, so.called endolymphatic radiotherapy, we treated 10 cases with malignant lymphoma and found a marked tumor reduction to normal size in all the 10 cases we tried. It seems that this method is one of the most effective therapeutic methods for malignant lymphoma, espe. cially invading into the retroperitoneal lymph nodes.</p

Experimental studies of the endolymphatic radiotherapy

By injecting 131I-Lipiodol into lymphatics of the dorsum of dog feet, the distribution of 13JI in the lymph nodes and other principal organs as well as its histological effect were studied periodically after the injection for the period of two months. The characteristic feature of J3JI distribution was the fact that J31I was accumulated into lymph nodes markedly higher than in any other organs and it was retained there over a long period of time. Histological examinations of the lymph nodes revealed a marked lymphocytopenia, the loss of germinal center, practically complete loss of lymphoid elements already 5 days after injection, and marked fibrosis. In the lung a considerable J3JI·distribution could be seen in early stage:, but with lapse of time it decreased rapidly. The distribution in other organs such as liver, spleen, bone marrow, kidney, ureter, bladder, thyroid gland, pancreas, testicles and small and large intestines was negligible in amount, and any specific histologic effect of irradiation could not be recognized in these organs including the lung. From these results, the authors concluded that 131I-Lipiodol has a selective activity on lymph nodes by injecting it via lymphatics and it is a safe method in clinical application to treat the patients bearing malignant lymphoma or metastatic lymph nodes.</p

New Stable Sulfonium Ylides. 1-Dimethylsulfuranylidene-l-phenylsulfonyl-2-propanone and Related Compounds

The preparation of the title compounds as a new type of stable S-ylides has been described. The reaction of 1-dimethylsulfuranylidene-1-phenylsulfonyl-2-propanone (IIb) with lithium aluminium hydride was found to result in the formation of trans-phenylpropenylsulfone (IV), phenylsulfonyl-2-propanone (Ib), and an unidentified paraffin as major products

Lactone Carboxylic Acids. IV. Reaction of Ethyl Chloroarylpyruvate with Ethyl Malonate

The condensation of ethyl chloroarylpyruvate (Ⅰ) with ethyl malonate in the presence of sodium ethoxide afforded γ-aryl-α,β-dicarbethoxy-⊿(β),γ-butenolide. On the basis of the chemical and spectral evidences, the structure of the product (II) has been elucidated. This reaction provides new routes to α,β-dicarboalkoxy-γ-butyrolactones and/or to γ-ketocarboxylic acids

Energy Distribution in Electrical Discharge Machining with Graphite Electrode

In EDM, the machining characteristics greatly depend on the energy distribution. Therefore, it is very important to clarify the energy distribution for understanding various phenomena in EDM. In this paper, the energy distribution in EDM with graphite electrode is investigated by measuring the temperatures of electrode and workpiece. Experimental analysis shows that the material removal rate depends on energy density while the electrode wear greatly depends on the adhesion of heat resolved carbon from machining fluid, and the energies distributed into electrode and workpiece are almost constant regardless of pulse duration

月経異常患者の尿中17-Ketosteroid分画に関す｣る研究

Reently, it has been discussed the menstrual disorder caused by deranged metabolism of androgens in ovaries. While the derangement may not be demonstrable by urinary total 17-KS estimation, it is necessary to study urinary 17-KS in detail such as 1) fractionation study of 17-KS, 2) adrenal suppression and gonadal stimulation, dynamic test, after Netter, 3) ratio analysis of specific 17-KS fraction, as androsterone or DHA (dehydoepiandrosterone), to total 17-KS. The ratio analysis of urinary 17-KS after Yoshida were performed in 32 cases of menstrual disorder and 19 carses of normal female in proliferative phase and dynamic test was combined in 15 cases of menstrual disorder. 1) Specific change in urinary total 17-KS level has not been observed in the cases of menstrual disorder. 2) Urinary 17-KS fractions also did not show specific excretion pattern in these patients. 3) The ratio analysis of androsterone/total 17-KS and DHA/total 17-KS clearly revealed deranged metabolism of androgens in Primary amenorrhea patients. 4) The ratio analysis combined dynamic test demonstrated more clearly the deranged metabolism. As the conclusion, it should be emphasized that the ratio analysis and the dynamic test were required in evaluating deranged steroid metabolism

Studies on the acid-base properties of the ZnBr2NaBr molten salt system

The acid-base properties of the ZnBr2-NaBr melts at 623 K were investigated on the basis of the electromotive force measurements of a zinc-zinc concentration cell. The following two chemical equilibria were postulated to describe the acid-base character of the melts.</p

The Effects of Font Type on Reading Accuracy and Fluency in Japanese Children with Developmental Dyslexia

We administered rapid reading tasks in Japanese children (32 with typical development and 24 with developmental dyslexia), and investigated the effects of two different font types: Rounded-Gothic and Mincho style font. In the experiment, we used four kinds of stimuli: two scripts (paragraphs and random kana character non-words) in two font types (Rounded-Gothic and Mincho style font). In this experiment, the duration time, the number of errors and the number of self-corrections were measured during reading. Participants were asked which font type was easier to read. There was no significant difference in the duration time, the number of errors and the number of self-corrections between two types of fonts among the 56 participants. On the other hand, regarding subjective readability, the developmental dyslexia group reported that the Rounded-Gothic font was easier to read. There was a difference between objective and subjective readability. In this study, there was no difference in reading performance of Rounded-Gothic and Mincho style fonts in Japanese children with developmental dyslexia

Cognitive Abilities Related to Reading and Writing Skills in Chinese Third-grade Children

In this study, we analysed the cognitive abilities that predict reading and writing attainment in the Chinese language for Mandarin-speaking children. A total of 140 Chinese third-graders studying in Ningbo, Zhejiang were evaluated for their visual cognition including visual perception and memory, naming speed, vocabulary knowledge, phonological skills, nonverbal intelligence, and abilities to read and write. The results of multiple regression analyses revealed that word and nonword reading accuracy were predicted to a significant degree by visual memory and phonological awareness, respectively. Naming speed significantly contributed to the reading speeds regarding words, nonwords, and paragraphs. Our results also showed that the scores in word and nonword reading predicted the scores of writing as well. Visual memory and phonological awareness are essential for reading Chinese accurately, while naming speed is an important factor for Chinese reading fluency. The present results have implications regarding the design of useful tasks that screen poor readers of Chinese

Micro-Welding Of High Thermal Conductive Material Aluminum-Graphite Composite By Pulsed ND:YAG Laser.

The development of advanced materials with superior high thermal properties and high specific strength has led to new metal matrix composites (MMCs) as a great attractive material in electrical and electronic industries. In order to manufacture more practical component from MMCs, a tech-nique for joining MMCs to other similar composites or monolithic materials is strongly required. Therefore, the reliable and economic joining technique is investigated to increase the applications of MMCs. In this study, the overlap welding of pure aluminum and super thermal conductive (STC) aluminum-graphite composite was experimentally and numerically investigated by using a pulsed Nd:YAG laser. In order to discuss the welding of dissimilar materials with different thermophysical properties, the temporal change of heat input was controlled by arranging the laser pulse waveform. The porosities and bumps were observed as the remarkable weld defects in the welding process without a pulse control. On the other hand, the weld bead was largely free of defects, and a size of bump was relatively small with the appropriate controlled pulse waveform. It was clarified that the laser welded joint of an aluminum and a STC aluminum-graphite composite could be successfully achieved with the better weld penetration stability by the appropriate controlled pulse waveform