Mitotic chromosomes fold by condensin-dependent helical winding of chromatin loop arrays

Chromosome organization investigation through Hi-CMitotic chromosome morphogenesis occurs through condensin-mediated disassembly of the interphase conformation and formation of extended prophase loop arrays that then shorten by condensin-dependent helical winding.Gibcus JH, Samejima K, Goloborodko A, Samejima I et al. A pathway for mitotic chromosome formation. Science 2018 Feb 9;359(6376). PMID: 2934836