252 research outputs found

    Cross-Sector Review of Drivers and Available 3Rs Approaches for Acute Systemic Toxicity Testing

    Get PDF
    Acute systemic toxicity studies are carried out in many sectors in which synthetic chemicals are manufactured or used and are among the most criticized of all toxicology tests on both scientific and ethical grounds. A review of the drivers for acute toxicity testing within the pharmaceutical industry led to a paradigm shift whereby in vivo acute toxicity data are no longer routinely required in advance of human clinical trials. Based on this experience, the following review was undertaken to identify (1) regulatory and scientific drivers for acute toxicity testing in other industrial sectors, (2) activities aimed at replacing, reducing, or refining the use of animals, and (3) recommendations for future work in this area

    Health assessment document for 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) and related compounds.

    No full text
    "Draft, do not quote or cite.""August 1994."Includes bibliographical references.Photocopy.Mode of access: Internet

    Methods for measuring the toxicity and bioaccumulation of sediment-associated contaminants with freshwater invertebrates.

    No full text
    "June 1994."Includes bibliographical references (p. 90-100).Mode of access: Internet

    Survey of Fish Contamination in Small Wadeable Streams in the Mid-Atlantic Region

    No full text
    122 pages; available for download at the link below.in 1993 and 1994, fish tissue samples were collected from first, second and third order streams in the Mid-Atlantic Region of the United States. The tissue samples were prepared from whole fish from prioritized lists of Small Target Species and Large Target Species. The two types of samples were analyzed for 56 contaminants, of which 22 had median values that were above the detection limits for at least one category of fish. For this report, the data analyses were conducted in order to determine 1) exposure to contaminants, 2) the magnitude of exposure, and 3) the location of the sites which exceeded toxicological benchmark values. All sites from which samples were taken showed exposure to at least one contaminant. In order to determine the magnitude of this exposure, no observed adverse effects level (NOAEL) benchmark values for 16 of the analytes were used. These NOAEL benchmark values are estimates of the greatest concentration of contaminants at which it is unlikely that the belted kingfisher (Megaceryle alcyon) would suffer adverse effects from consumption. These NOAEL benchmark values were then compared to the concentration of contaminants found in Small Target Species tissue sampled at each site. Maps were generated which showed the locations of the sites that exceeded the NOAEL benchmark values. Seventy sites (100%) exceeded at least one NOAEL benchmark value and twenty two sites (31.4%) exceeded four or more NOAEL benchmark values. The number of sites exceeding multiple NOAEL benchmark values suggests a comprehensive study of fish tissue contaminants is warranted for the region

    Proceedings of the Delmarva Coastal Bays Conference III: Tri-State Approaches to Preserving Aquatic Resources

    No full text
    162 pages; available for download at the link below.On November 12-13, 1999, approximately 300 people attended the Delmarva Coastal Bays Conference III: Tri-State Approaches to Preserving Aquatic Resources (CBCIII). The conference was organized by the Assateague Coastal Trust with planning and financial assistance from twenty-one local, state and federal agencies and organizations - plus support from the local business community. Much has been accomplished since the preceding Delmarva Coastal Bays Conference II held in 1996, including formation of the Maryland Coastal Bays Program, accomplishments by the Delaware Center for the Inland Bays, and the generally increased awareness along Delmarva's seaside of the importance of protecting the aquatic resources that underpin the local economy and quality of life. To date, relatively more attention has been given to land use and development issues that affect water quality. CBCIII has narrowed the focus to the direct impacts on the bays' "critters" from such aquatic stresses as habitat destruction, increaing harvest pressures, invasive species and diseases, and the relevant resource management strategies
    • ā€¦
    corecore