187 research outputs found
Clinical value of procedures in invasive cardiology for the assessment and relief of myocardial ischemia
ACTH- and cortisol-associated neutrophil modulation in coronary artery disease patients undergoing stent implantation
BACKGROUND: Psychosocial stress and activation of neutrophil granulocytes are increasingly recognized as major risk factors of coronary artery disease (CAD), but the possible relationship of these two factors in CAD patients is largely unexplored. Activation of neutrophils was reported to be associated with stenting; however, the issue of neutrophil state in connection with percutaneous coronary intervention (PCI) is incompletely understood from the aspect of stress and its hypothalamic-pituitary-adrenal axis (HPA) background. Thus, we aimed to study cortisol- and ACTH-associated changes in granulocyte activation in patients undergoing PCI. METHODOLOGY/PRINCIPAL FINDINGS: Blood samples of 21 stable angina pectoris (SAP) and 20 acute coronary syndrome (ACS) patients were collected directly before (pre-PCI), after (post-PCI) and on the following day of PCI (1d-PCI). Granulocyte surface L-selectin, CD15 and (neutrophil-specific) lactoferrin were analysed by flow cytometry. Plasma cortisol, ACTH, and lactoferrin, IL-6 were also assayed. In both groups, pre- and post-PCI ratios of lactoferrin-bearing neutrophils were relatively high, these percentages decreased substantially next day; similarly, 1d-PCI plasma lactoferrin was about half of the post-PCI value (all p</=0.0001). Post-PCI ACTH was reduced markedly next day, especially in ACS group (SAP: p<0.01, ACS: p</=0.0001). In ACS, elevated pre-PCI cortisol decreased considerably a day after stenting (p<0.01); in pre-PCI samples, cortisol correlated with plasma lactoferrin (r approximately 0.5, p<0.05). In 1d-PCI samples of both groups, ACTH showed negative associations with the ratio of lactoferrin-bearing neutrophils (SAP: r = -0.601, p<0.005; ACS: r = -0.541, p<0.05) and with plasma lactoferrin (SAP: r = -0.435, p<0.05; ACS: r = -0.609, p<0.005). CONCLUSIONS/SIGNIFICANCE: Pre- and post-PCI states were associated with increased percentage of activated/degranulated neutrophils indicated by elevated lactoferrin parameters, the 1d-PCI declines of which were associated with plasma ACTH in both groups. The correlation of plasma cortisol with plasma lactoferrin in the extremely stressed ACS before stenting, however, suggests an association of cortisol with neutrophil activation
Videodensitometric time-density curve change after alcohol 5 septal ablation of obstructive hypertrophic cardiomyopathy
Functional assessment of a left coronary-pulmonary artery fistula by coronary flow reserve
We report a 71-year-old man who presented with atypical chest pain. Coronary angiography did not reveal left main or proximal left anterior descending coronary artery stenosis, but a fistulous communication with a stronger tube-like fistula was present originating from the proximal left anterior descending coronary artery and emptying into the main pulmonary artery. Fractional flow reserve and coronary flow reserve measurements were performed to gain more data on the potential functional aspects of this fistula. With the present case, the importance of functional evaluation of these fistulas is demonstrated
Az anterográd technikák szerepe a krónikus teljes koszorúér-elzáródás perkután revaszkularizációjában = The Role of Antegrade Techniques in Current Practice of Percutaneous Coronary Interventions for Chronic Total Occlusions
Rotációs aterectomia alkalmazása krónikus teljes koronária-okklúzió katéteres revaszkularizációjában = Use of rotational atherectomy in chronic total occlusion percutaneous revascularization
A guidingkatéter szerepe a thrombusaspiráció hatékonyságának növelésében: Esetismertetés = The role of the guiding catheter to increas the efficiency of thrombus aspiration
A koronáriabifurkációk percutan kezelési lehetőségei: a simplified highway-technika = Simplified highway technique for the treatment of bifurcation lesions – initial experiences in our center
KrĂłnikus jobb koronária-elzárĂłdás megnyitása homokoronáriás kollaterálison keresztĂĽli retrográd megközelĂtĂ©ssel = Recanalisation of a right coronary CTO using retrograde approach via homocoronary collateral
Detection of perfusion abnormalities on coronary angiograms in hypertension by myocardium selective densitometric perfusion assessments
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