The Therapeutic Effects of Conservative Treatments on Burn Scars

Hypertrophic scar, which can be seen even after minor burn injuries, is a common complication and generally develops within 6–8 weeks following reepithelization. Hypertrophic scar/keloid is often seen when the injury affects the reticular dermis and, in particular, after a deep dermal or full thickness burn. There are various options used in the treatment of burn scar. The purpose of this chapter is to provide the reader a brief information on the conservative treatment methods used in burn scar treatment

Platelet-Rich Plasma in Burn Treatment

As a general definition, platelet-rich plasma (PRP) is the concentration of autologous human platelets in a small amount of plasma. PRP contains important growth factors deposited in alpha-granules of platelets and plasma proteins such as fibrin, fibronectin, and vitronectin. PRP has been shown to improve wound healing process in acute trauma wounds, incisional wounds, and chronic nonhealing wounds and is a beneficial agent in reconstructions of soft and hard tissue. Furthermore, PRP enhances differentiation of epithelial cell and collagen bundle organization. Effects of growth factors in PRP on wound healing and successful results obtained with PRP treatment in other types of wound lead to the use of PRP for burn treatment

The link between learning performance, immobility in the forced swim test, and hippocampal glia

Aim: To obtain maximal translational insights from animal models of depression, we need to know the meaning of behavioral parameters of animal models. The extent of construct and face validities of behavioral despair in the form of behavioral immobility in forced swim test (FST) is disputed. In this study, learning performance in a dual solution T-Maze and immobility on the 2nd day of FST was compared to shed light on this debate. Furthermore, we aimed to inspect the relationship between hippocampal glial densities and behaviors observed. Method: Twelve adult male Sprague Dawley rats were tested in the dual-solution T-Maze and in FST. Subsequently, hippocampal slices were obtained, astrocyte and microglia cells were stained, and the densities were calculated for each subject. Results: The rats utilized different learning strategies to solve the T-Maze. But irrespective of strategy, the rats that exhibited an overall efficiency in their learning performance, remained immobile for longer durations on the 2nd day of the FST. No significant relationship was detected between hippocampal microglia and behavioral indices in T-Maze and FST. However, we detected a significant positive correlation with CA1 astrocyte density and T-Maze learning and dentate gyrus CA1 astrocyte density and headshake behavior in FST. Conclusions: The subjects showing a better cognitive performance in the T-Maze were immobile longer in the FST. This observation raises doubts about immobility as depression index and posits that it might reflect better learning. Our results also suggest that hippocampal glia cell types are differentially involved in cognition and affect

The drug-transporter gene MDR1 C3435T and G2677T/A polymorphisms and the risk of multidrug-resistant epilepsy in Turkish children

One-third of all individuals with epilepsy are resistant to antiepileptic drug (AED) treatment. Antiepileptic treatment response has been suggested to be modulated by genetic polymorphisms of drug efflux transporters. Several polymorphic variants within the multidrug resistance 1 (MDR1) gene, which encodes the major transmembrane efflux transporter P-glycoprotein, have been proposed to be associated with AED resistance in epilepsy patients. The aim of this study was to evaluate the effect of C3435T and G2677T/A polymorphisms of MDR1 on AED resistance in Turkish children with epilepsy. MDR1 C3435T and G2677T/A were genotyped in 152 patients with epilepsy, classified as drug-resistant in 69 and drug-responsive in 83. Genotypes of the C3435T and G2677T/A polymorphisms were determined by polymerase chain reaction followed by restriction fragment length polymorphism. Genotype and allele frequencies of C3435T and G2677T/A polymorphisms of the MDR1 gene did not differ between drug-resistant and drug-responsive epilepsy patients. Our results suggest that MDR1 C3435T and G2677T/A polymorphisms are not associated with AED resistance in Turkish epileptic patients. To clarify the exact clinical implication of the MDR1 polymorphisms on the multidrug resistance in epilepsy, further investigations in various ethnic populations would be necessary

Journal of Air Transportation, Volume 10, No. 2

Topics discussed include: Mitigation Alternatives for Carbon Dioxide Emissions by the Air Transport Industry in Brazil; Air Transport Regulation Under Transformation: The Case of Switzerland; An Estimation of Aircraft Emissions at Turkish Airports; Guide to the Implementation of Iso 14401 at Airports; The Impact of Constrained Future Scenarios on Aviation and Emissions; The Immediate Financial Impact of Transportation Deregulation on the Stockholders of the Airline Industry; Aviation Related Airport Marketing in an Overlapping Metropolitan Catchment Area: The Case of Milan's Three Airports; and Airport Pricing Systems and Airport Deregulation Effects on Welfare

The prevalence of probable migraine and sleep quality among women aged 20-49 living in a semi-rural area in western Turkey

Background: We aimed to evaluate the prevalence of probable migraine, to examine the factors associated with probable migraine and to assess the level of sleep quality among women aged 20-45 who were living in the county town named Mahmudiye, in Eskisehir, in Turkey.Methods: The study was carried out in all women aged 20-45 years in Mahmudiye. 69.2% of women (n=570) comprised the study group. Questionnaire consisted of three parts: The first part included several socio-demographic, nutritional and health characteristics. The second part included questions about the headache type and third part included Pittsburgh Sleep Quality Index (PSQI). Migraine type headache was scanned via the International Headache Society (IHS) criteria for migraine. There were eight criteria which were defined by IHS. Individuals who possessed the six of the eight criteria were defined as “probable migraine”.Results: The mean age of the participants was 32.8±7.3 years. Prevalence of probable migraine was 13.3% (n=60) and it was significantly higher in women who have been smoking and who had a physician diagnosed chronic diseases. Of the women, 45.1% had poor sleep quality based on the PSQI. The sleep quality of probable migraineurs was found significantly lower than healthy women.Conclusions: To control the probable migraine symptoms and attacks, we suggest to giving regular treatment to women with chronic diseases and reducing the smoking.

Utjecaj lucerne i koncentriranih krmiva na razinu kolesterola i sastav masnih kiselina u serumu i iznutricama janjadi

This study was conducted to investigate the effects of fresh, ensiled and dried alfalfa on the fatty acid composition and cholesterol level of the serum, liver, kidney and spleen samples in yearling sheep. Forty Akkaraman lambs, 4 months of age, with an average body weight of 21 kg were used in the study. All diets were formulated to be isonitrogenous and isoenergetic. The lambs were divided into four groups according to feed: wheat straw as roughage (Control group, C); fresh alfalfa as roughage (AF group); ensiled alfalfa (AS group); and dried alfalfa (AD group). The alfalfa group had lower saturated fatty acid (SFA) and higher polyunsaturated fatty acid (PUFA) contents than the wheat straw group. In parallel, SFA concentrations in the serum and offal (liver, kidney and spleen) were signifi cantly higher in the controls, whereas the highest PUFA amounts were recorded in lambs fed with fresh alfalfa. Serum and offal proportions of ω3 and ω6 fatty acids significantly increased except in serum ω3 content of lambs fed with alfalfa. However, the cholesterol level decreased in all groups given alfalfa. In conclusion, the results of this study suggest that alfalfa consumption causes a significant decrease in cholesterol levels and a significant increase in PUFA levels in lambs. Additionally, it may be said that the risk of coronary heart diseases may decrease in humans who consume the offal of lambs fed with alfalfa.U radu su istraženi učinci svježe, silirane i sušene lucerne na sastav masnih kiselina i razinu kolesterola u serumu te u uzorcima jetre, bubrega i slezene jednogodišnjih ovaca. U istraživanju je korišteno 40 janjadi akaraman pasmine, u dobi od 4 mjeseca, prosječne tjelesne mase od 21 kg. Obroci su bili ujednačeni s obzirom na sadržaj dušika i energije. S obzirom na upotrijebljenu krmu janjad je bila podijeljena u četiri skupine: kontrolna skupina je dobivala pšeničnu slamu, skupina AF je dobivala svježu lucernu, skupina AS siliranu lucernu te skupina AD sušenu lucernu. Lucerna je sadržavala manje zasićenih masnih kiselina (SFA) i više polinezasićenih masnih kiselina (PUFA) u odnosu na pšeničnu slamu. Usporedno, koncentracije SFA u serumu i iznutricama (jetrima, bubregu i slezeni) bile su značajno više u kontrolnoj skupini, dok su najviše koncentracije PUFA zabilježene u janjadi hranjene svježom lucernom. Omjer ω3 i ω6 masnih kiselina bio je značajno povišen, osim koncentracije ω3 u serumu janjadi hranjene lucernom. Međutim, razina kolesterola bila je snižena u svim skupinama hranjenim lucernom. Zaključno, rezultati ovoga istraživanja upućuju da hranidba lucernom dovodi do značajnoga sniženja razine kolesterola i značajnoga povišenja razine PUFA u janjadi. Dodatno bi se moglo reći da je u osoba koje konzumiraju iznutrice janjadi hranjene lucernom smanjen rizik od bolesti srca i krvnih žila

Eating disorders and anxiety among high school students in Western area of Turkey

Background Eating disorders (ED) are the one of the most common chronic illness among adolescents. The aim of the present study was to investigate eating disorders and it's associations between anxiety among high school students in Sivrihisar in Eskisehir, Turkey.Methods: This cross-sectional study was carried out in the high school students of center of Sivrihisar between 01 January 2014 and 28 February 2014. The questionnaire prepared according to literature, consisting of 3 parts (socio-demographic characteristics, eating attitude test (EAT-40) and beck anxiety inventory (BAI)). The students completed questionnaire in the presence of a member of the research team. The data collected were self-reported by the students.Results: Of the study group 64.4% (n=625) were females and 35.6% (n=345) were males. The prevalence of eating disorder was 13.0% (n=126). The mean and standard deviation of students' total score of EAT-40 were 18.80±9.88 (ranged 3 to 95).  The mean and standard deviation of students' total score of BAI were 20.32±12.32 (ranged 0 to 63). The positive weak correlation was found between the total scores of EAT-40 and BAI (r=0.178; p=0.001).Conclusions: ED is an important health problem for adolescents. On the studies upon epidemiology of ED towards high school students, socio-economic factors should be assessed in more detailed and more comprehensive perspective.