Acetylcholinesterase, Tyrosinase, α-Glucosidase inhibition by Ammodaucus leucotrichus Coss. & Dur. Fruits Essential oil and Ethanolic Extract and Molecular Docking Analysis

Medicinal and aromatic plants serve as valuable reservoirs of bioactive molecules and mineral compounds that are harnessed for therapeutic and agro-food applications. The objective of this study was to assess the inhibitory enzyme properties of Ammodaucus leucotrichus Coss & Dur fruit essential oil, as well as its aqueous and ethanol extracts, against acetylcholinesterase, tyrosinase, and α-glucosidase. Additionally, the antioxidant activity of these natural mixtures was evaluated using three different methods: DPPH, FRAP, and β-carotene bleaching tests. Furthermore, this research endeavors to examine the mineral constituents of various components of the plant under investigation. The various natural combinations that were examined exhibited a notable inhibitory impact on the enzymes acetylcholinesterase (67.56-92.30%), tyrosinase (57.52-63.44%), and α-glucosidase (61.22-72.49%). The analyzed extracts also demonstrate a significant antioxidant activity. Furthermore, the results obtained from the analysis indicate a notable presence of both macro and microelements, such as calcium (2.028 mg/g for leaves and 1.787 mg/g for fruits), within the Ammodaucus leucotrichus Coss & Dur plant. The current study supports the significance of utilizing Ammodaucus leucotrichus Coss & Dur fruits in the medicinal and agro-alimentary sectors. The utilization of molecular docking techniques was employed in order to make predictions regarding the therapeutic effects of Ammodaucus leucotrichus Coss & Dur fruits

Synergistic and antagonistic effects between halide ions and carboxymethyl cellulose for the corrosion inhibition of mild steel in sulphuric acid solution

The corrosion and corrosion inhibition effect of carboxymethyl cellulose (CMC) for mild steel in sulphuric acid medium was investigated using chemical (weight loss and hydrogen evolution) techniques at 30–60 �C. The effect of addition of halide ions (Cl-, Br -, and I-) was also studied. It was found that CMC functions as an inhibitor for acid induced corrosion for mild steel. Inhibition efficiency increases with increase in immersion time but decreases with increase in temperature. Addition of halide ions reveals that chloride ions (Cl-) antagonize the inhibition process whereas iodide ions (I-) exert synergistic effect on the corrosion inhibition by CMC. Corrosion inhibitive effect was afforded by adsorption of CMC molecules onto the mild steel surface both in the absence and presence of halide ions which was found to follow Langmuir adsorption isotherm model. The phenomenon of physical adsorption is proposed from decrease in inhibition efficiency with increase in temperature. The inhibition mechanism was further corroborated by the values of thermodynamic and kinetic parameters obtained from the experimental data. Keywords Carboxymethyl cellulose, Mild steel, Corrosion inhibition, Acid, Halides, Synergis

Career choices and global health engagement: 24-year follow-up of U.S. participants in the Indiana University-Moi University elective

Background Global health experiences evoke a profound awareness of cultural differences, inspire learners to prioritize professional values, and provide a lens for addressing global health care challenges. This study compares the long-term career and practice choices of participants in a 2-month Indiana University-Moi University, Kenya elective from 1989–2013 with those of a control group. Methods Global health elective (GHE) participants and a random sample of alumni without GHE experience were surveyed on their clinical practice, public health and global health activities. Results Responses from 176 former participants were compared with a control group of 177 alumni. GHE participants were more likely than similar controls to provide care to underserved U.S. populations (p=0.037), spend time in global health, public health, and public policy activities (p=0.005) and be involved in global health advocacy (p=0.001). Using multivariable analysis, GHE participants were more likely to be generalists (p<0.05), report that healthcare costs influenced medical decision-making (p<0.05), and provide healthcare outside the U.S. for ≥1 week/year (p<0.001). Conclusions Many years out of training, GHE participants were more likely to be generalists working with underserved populations, to be cost-conscious in their healthcare decision-making, and to be involved in global health, public health or public policy. Implications With the primary care provider shortage and need for greater awareness among providers of healthcare costs, our study shows that that global health experiences may yield broader benefits to the U.S. medical system

The Practitioner\u27s Guide to Global Health: an interactive, online, open-access curriculum preparing medical learners for global health experiences

BACKGROUND: Short-term experiences in global health (STEGH) are increasingly common in medical education, as they can provide learners with opportunities for service, learning, and sharing perspectives. Academic institutions need high-quality preparatory curricula and mentorship to prepare learners for potential challenges in ethics, cultural sensitivity, and personal safety; however, availability and quality of these are variable. OBJECTIVE: The objective of this study is to create and evaluate an open-access, interactive massive open online course (MOOC) that prepares learners to safely and effectively participate in STEGH, permits flexible and asynchronous learning, is free of charge, and provides a certificate upon successful completion. METHODS: Global health experts from 8 countries, 42 institutions, and 7 specialties collaborated to create The Practitioner\u27s Guide to Global Health (PGGH): the first course of this kind on the edX platform. Demographic data, pre- and posttests, and course evaluations were collected and analyzed. RESULTS: Within its first year, PGGH enrolled 5935 learners from 163 countries. In a limited sample of 109 learners, mean posttest scores were significantly improved (p \u3c 0.01). In the course\u27s second year, 213 sampled learners had significant improvement (p \u3c 0.001). CONCLUSION: We created and evaluated the first interactive, asynchronous, free-of-charge global health preparation MOOC. The course has had significant interest from US-based and international learners, and posttest scores have shown significant improvement

Dissolution Control of Mg by Cellulose Acetate–Polyelectrolyte Membranes

Cellulose acetate (CA)-based membranes are used for Mg dissolution control: the permeability of the membrane is adjusted by additions of the polyelectrolyte, poly(N,N-dimethylaminoethyl methacrylate) (PDMAEMA). Spin-coated films were characterized with FT-IR, and once exposed to an aqueous solution the film distends and starts acting as a membrane which controls the flow of ions and H2 gas. Electrochemical measurements (linear sweep voltammograms, open-circuit potential, and polarization) show that by altering the CA:PDMAEMA ratio the dissolution rate of Mg can be controlled. Such a control over Mg dissolution is crucial if Mg is to be considered as a viable, temporary biomedical implant material. Furthermore, the accumulation of corrosion products between the membrane and the sample diminishes the undesirable effects of high local pH and H2 formation which takes place during the corrosion process.Peer reviewe

Corrosion Protection Effect of Chitosan on the Performance Characteristics of A6063 Alloy

This article outlines the behaviour of water-soluble chitosan as an effective inhibitor on aluminium alloy in 3.65% NaCl at room temperature. The inhibitive ability of water-soluble chitosan was examined using electrochemical potentiodynamic polarization techniques, mass loss measurements and computational studies. The outcome of the experiment reveals that chitosan inhibited aluminium alloy in sodium chloride solution exhibits better corrosion protection than the uninhibited because chitosan nanoparticles minimize the ingression of chloride ion into the active sites of aluminium alloy by forming thin film on its surface. The losses in mass by the inhibited aluminium alloy were found to reduce as the concentration of chitosan increases. Results obtained showed that chitosan could offer inhibition efficiency above 70%. Polarization curve demonstrated that chitosan in 3.65% NaCl at room temperature acted as a mixed-type inhibitor. Adsorption of chitosan nanoparticles on the aluminium alloy was found to follow Langmuir adsorption isotherm with correlation regression coefficient (R2 ) value of 0.9961

Surface modification of Aluminum through layered coating of ethanolic extract of waste green chilly pedicles by drop casting, and corrosion testing in salty water : Ethanol extract of Waste green chilly pedilcles as a coating material for corrosion prevention of Aluminum in 0.5 M NaCl

This work assesses potential of waste green chillies pedicles (GCP) in the prevention of Aluminium (Al) corrosion in 0.5 M NaCl. GCP is a natural bio-waste. The GCP has been extracted into ethanol (EACP) and characterized by FTIR spectroscopy (FS). The layers of EACP are deposited on Al through drop casting. The coated Al samples are tested by open circuit potential (OCP), Tafel polarization curves (TPC), and electrochemical impedance spectroscopy (EIS). The results have confirmed that EACP layers significantly prevent Al in NaCl. However, the best performance is obtained for 2 layers of EACP (87%, TPC). The surface examination is performed by field emission scanning electron microscopy (FESEM) and electron dispersive X-ray spectroscopy (EDX), which shows that damage of EACP-coated Al in NaCl is lesser than bare Al. An illustration of corrosion prevention of Al by EACP is also done.&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp