329 research outputs found
Evolution of active and polar photospheric magnetic fields during the rise of Cycle 24 compared to previous cycles
The evolution of the photospheric magnetic field during the declining phase
and minimum of Cycle 23 and the recent rise of Cycle 24 are compared with the
behavior during previous cycles. We used longitudinal full-disk magnetograms
from the NSO's three magnetographs at Kitt Peak, the Synoptic Optical Long-term
Investigations of the Sun (SOLIS) Vector Spectro-Magnetograph (VSM), the
Spectromagnetograph and the 512-Channel Magnetograph instruments, and
longitudinal full-disk magnetograms from the Mt. Wilson 150-foot tower. We
analyzed 37 years of observations from these two observatories that have been
observing daily, weather permitting, since 1974, offering an opportunity to
study the evolving relationship between the active region and polar fields in
some detail over several solar cycles. It is found that the annual averages of
a proxy for the active region poloidal magnetic field strength, the magnetic
field strength of the high-latitude poleward streams, and the time derivative
of the polar field strength are all well correlated in each hemisphere. These
results are based on statistically significant cyclical patterns in the active
region fields and are consistent with the Babcock-Leighton phenomenological
model for the solar activity cycle. There was more hemispheric asymmetry in the
activity level, as measured by total and maximum active region flux, during
late Cycle 23 (after around 2004), when the southern hemisphere was more
active, and Cycle 24 up to the present, when the northern hemisphere has been
more active, than at any other time since 1974. The active region net proxy
poloidal fields effectively disappeared in both hemispheres around 2004, and
the polar fields did not become significantly stronger after this time. We see
evidence that the process of Cycle 24 field reversal has begun at both poles.Comment: Accepted for publication in Solar Physic
Exchange-correlation vector potentials and vorticity-dependent exchange-correlation energy densities in two-dimensional systems
We present a new approach how to calculate the scalar exchange-correlation
potentials and the vector exchange-correlation potentials from current-carrying
ground states of two-dimensional quantum dots. From these exchange-correlation
potentials we derive exchange-correlation energy densities and examine their
vorticity (or current) dependence. Compared with parameterizations of
current-induced effects in literature we find an increased significance of
corrections due to paramagnetic current densities.Comment: 5 figures, submitted to PR
Evidence that Meningeal Mast Cells Can Worsen Stroke Pathology in Mice
Stroke is the leading cause of adult disability and the fourth most common cause of death in the United States. Inflammation is thought to play an important role in stroke pathology, but the factors that promote inflammation in this setting remain to be fully defined. An understudied but important factor is the role of meningeal-located immune cells in modulating brain pathology. Although different immune cells traffic through meningeal vessels en route to the brain, mature mast cells do not circulate but are resident in the meninges. With the use of genetic and cell transfer approaches in mice, we identified evidence that meningeal mast cells can importantly contribute to the key features of stroke pathology, including infiltration of granulocytes and activated macrophages, brain swelling, and infarct size. We also obtained evidence that two mast cell-derived products, interleukin-6 and, to a lesser extent, chemokine (C-C motif) ligand 7, can contribute to stroke pathology. These findings indicate a novel role for mast cells in the meninges, the membranes that envelop the brain, as potential gatekeepers for modulating brain inflammation and pathology after stroke
Acoustic Power Absorption and its Relation with Vector Magnetic Field of a Sunspot
The distribution of acoustic power over sunspots shows an enhanced absorption
near the umbra--penumbra boundary. Earlier studies revealed that the region of
enhanced absorption coincides with the region of strongest transverse potential
field. The aim of this paper is to (i) utilize the high-resolution vector
magnetograms derived using Hinode SOT/SP observations and study the
relationship between the vector magnetic field and power absorption and (ii)
study the variation of power absorption in sunspot penumbrae due to the
presence of spine-like radial structures. It is found that (i) both potential
and observed transverse fields peak at a similar radial distance from the
center of the sunspot, and (ii) the magnitude of the transverse field, derived
from Hinode observations, is much larger than the potential transverse field
derived from SOHO/MDI longitudinal field observations. In the penumbra, the
radial structures called spines (intra-spines) have stronger (weaker) field
strength and are more vertical (horizontal). The absorption of acoustic power
in the spine and intra-spine shows different behaviour with the absorption
being larger in the spine as compared to the intra-spine.Comment: 18 pages, 7 figures, In Press Solar Physics, Topical Issue on
Helio-and-Astroseismolog
Seismology of the Sun : Inference of Thermal, Dynamic and Magnetic Field Structures of the Interior
Recent overwhelming evidences show that the sun strongly influences the
Earth's climate and environment. Moreover existence of life on this Earth
mainly depends upon the sun's energy. Hence, understanding of physics of the
sun, especially the thermal, dynamic and magnetic field structures of its
interior, is very important. Recently, from the ground and space based
observations, it is discovered that sun oscillates near 5 min periodicity in
millions of modes. This discovery heralded a new era in solar physics and a
separate branch called helioseismology or seismology of the sun has started.
Before the advent of helioseismology, sun's thermal structure of the interior
was understood from the evolutionary solution of stellar structure equations
that mimicked the present age, mass and radius of the sun. Whereas solution of
MHD equations yielded internal dynamics and magnetic field structure of the
sun's interior. In this presentation, I review the thermal, dynamic and
magnetic field structures of the sun's interior as inferred by the
helioseismology.Comment: To be published in the proceedings of the meeting "3rd International
Conference on Current Developments in Atomic, Molecular, Optical and Nano
Physics with Applications", December 14-16, 2011, New Delhi, Indi
Multiwavelength studies of MHD waves in the solar chromosphere: An overview of recent results
The chromosphere is a thin layer of the solar atmosphere that bridges the
relatively cool photosphere and the intensely heated transition region and
corona. Compressible and incompressible waves propagating through the
chromosphere can supply significant amounts of energy to the interface region
and corona. In recent years an abundance of high-resolution observations from
state-of-the-art facilities have provided new and exciting ways of
disentangling the characteristics of oscillatory phenomena propagating through
the dynamic chromosphere. Coupled with rapid advancements in
magnetohydrodynamic wave theory, we are now in an ideal position to thoroughly
investigate the role waves play in supplying energy to sustain chromospheric
and coronal heating. Here, we review the recent progress made in
characterising, categorising and interpreting oscillations manifesting in the
solar chromosphere, with an impetus placed on their intrinsic energetics.Comment: 48 pages, 25 figures, accepted into Space Science Review
Prevention of hepatic encephalopathy by administration of rifaximin and lactulose in patients with liver cirrhosis undergoing placement of a transjugular intrahepatic portosystemic shunt (TIPS): A multicentre randomised, double blind, placebo controlled trial (PEARL trial)
Introduction Cirrhotic patients with portal hypertension can suffer from variceal bleeding or refractory ascites and can benefit from a transjugular intrahepatic portosystemic shunt (TIPS). Post-TIPS hepatic encephalopathy (HE) is a common (20%-54%) and often severe complication. A prophylactic strategy is lacking. Methods and analysis The Prevention of hepatic Encephalopathy by Administration of Rifaximin and Lactulose in patients with liver cirrhosis undergoing placement of a TIPS (PEARL) trial, is a multicentre randomised, double blind, placebo controlled trial. Patients undergoing covered TIPS placement are prescribed either rifaximin 550 mg two times per day and lactulose 25 mL two times per day (starting dose) or placebo 550 mg two times per day and lactulose 25 mL two times per day from 72 hours before and until 3 months after TIPS placement. Primary endpoint is the development of overt HE (OHE) within 3 months (according to West Haven criteria). Secondary endpoints include 90-day mortality; development of a second episode of OHE; time to development of
Advances in Global and Local Helioseismology: an Introductory Review
Helioseismology studies the structure and dynamics of the Sun's interior by
observing oscillations on the surface. These studies provide information about
the physical processes that control the evolution and magnetic activity of the
Sun. In recent years, helioseismology has made substantial progress towards the
understanding of the physics of solar oscillations and the physical processes
inside the Sun, thanks to observational, theoretical and modeling efforts. In
addition to the global seismology of the Sun based on measurements of global
oscillation modes, a new field of local helioseismology, which studies
oscillation travel times and local frequency shifts, has been developed. It is
capable of providing 3D images of the subsurface structures and flows. The
basic principles, recent advances and perspectives of global and local
helioseismology are reviewed in this article.Comment: 86 pages, 46 figures; "Pulsation of the Sun and Stars", Lecture Notes
in Physics, Vol. 832, Rozelot, Jean-Pierre; Neiner, Coralie (Eds.), 201
Defining the Critical Hurdles in Cancer Immunotherapy
ABSTRACT: Scientific discoveries that provide strong evidence of antitumor effects in preclinical models often encounter significant delays before being tested in patients with cancer. While some of these delays have a scientific basis, others do not. We need to do better. Innovative strategies need to move into early stage clinical trials as quickly as it is safe, and if successful, these therapies should efficiently obtain regulatory approval and widespread clinical application. In late 2009 and 2010 the Society for Immunotherapy of Cancer (SITC), convened an "Immunotherapy Summit" with representatives from immunotherapy organizations representing Europe, Japan, China and North America to discuss collaborations to improve development and delivery of cancer immunotherapy. One of the concepts raised by SITC and defined as critical by all parties was the need to identify hurdles that impede effective translation of cancer immunotherapy. With consensus on these hurdles, international working groups could be developed to make recommendations vetted by the participating organizations. These recommendations could then be considered by regulatory bodies, governmental and private funding agencies, pharmaceutical companies and academic institutions to facilitate changes necessary to accelerate clinical translation of novel immune-based cancer therapies. The critical hurdles identified by representatives of the collaborating organizations, now organized as the World Immunotherapy Council, are presented and discussed in this report. Some of the identified hurdles impede all investigators, others hinder investigators only in certain regions or institutions or are more relevant to specific types of immunotherapy or first-in-humans studies. Each of these hurdles can significantly delay clinical translation of promising advances in immunotherapy yet be overcome to improve outcomes of patients with cancer
Localization of the murine cholecystokinin A and B receptor genes
We have determined the chromosomal locations of the two cholecystokinin (CCK) receptor genes in the mouse. Genetic localization utilized an interspecific backcross panel formed from the cross (C57BL/6J x Mus spretus ) F 1 x Mus spretus . Genomic DNAs from 94 individuals in the backcross were analyzed by Southern hybridization with rat CCK A and CCK B receptor cDNA probes. Unique map positions were determined by haplotype analysis with 650 previously mapped loci in the mouse backcross. The CCK A receptor gene ( Cckar ) mapped to mouse Chromosome (Chr) 5, in tight linkage with the DNA marker D5Bir8 . The CCK B receptor gene ( Cckbr ) mapped to mouse Chr 7, tightly linked to the β-hemoglobin locus ( Hbb ). This localization places Cckbr in the same region as the mouse obesity mutation tubby ( tub ), which also maps near Hbb (2.4±1.4 cM). Since CCK can function as a satiety factor when administered to rodents, localization of Cckbr near the tub mutation identifies this receptor as a possible candidate gene for this obesity mutation.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/47021/1/335_2004_Article_BF00352408.pd
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