Potential of Antifungal Drugs as Photosensitizers

In the present work, using commercially available formulation of polyene antifungal antibiotic amphotericin B, it is shown that its antifungal activity could be enhanced in combination with optical radiation corresponding to the absorption band of amphotericin B due to photodynamic effect. It is assumed that the radical processes dominate in the mechanism of photodynamic action in the presence of amphotericin B. Keywords: Amphotericin B, antimicrobial/antifungal photodynamic therapy (aPDT), lactate dehydrogenase (LDH), singlet oxygen, laser, LED