Broad Autism Phenotype

Broad autism phenotype is characterized by impairments in cognitive, social, communicative, behavioral and personality domains of close relatives to autistic individuals. Initial data derived from studies conducted on autism reflect mild autistic symptoms observed in siblings and parents of autistic individuals and this might be considered as an endophenotype for autism. With this review, we have aimed to summarize and interpret the entity of broad autism phenotype, within the context of its diagnostic assessment, its symptoms and relevant studies conducted so far

Structural dysconnectivity in offspring of individuals with bipolar disorder: The effect of co-existing clinical-high-risk for bipolar disorder

Background: Bipolar disorder (BD) might be associated in disturbances in brain networks. However, little is known about the abnormalities in structural brain connectivity which might be related to vulnerability to BD and predictive of the emergence of manic symptoms. No previous study has investigated the effect of subthreshold syndromes on structural dysconnectivity in offspring of parents with BD (BDoff)

Neurocognitive heterogeneity in young offspring of patients with bipolar disorder: The effect of putative clinical stages

Background: Bipolar disorder (BD) is associated with significant cognitive heterogeneity. In recent years, a number of studies have investigated cognitive subgroups in BD using data-driven methods and found that BD includes several subgroups including a severely impaired and a neurocognitively intact cluster. Studies in offspring of BD (BDoff) are particularly important to establish the timing of emergence of cognitive subgroups but studies investigating cognitive heterogeneity in BDoff are lacking. Our aim was to investigate cognitive heterogeneity in BDoff and the relationship between cognitive heterogeneity and putative clinical stages of BD

Neurocognition in young offspring of individuals with bipolar disorder: The role of co-existing familial and clinical high-risk for bipolar disorder

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