Synthesis and characterisation of some metal complexes of hybrid phosphorus-nitrogenligands: the crystal structure of 1-(diphenylphosphino)-2-(2-pyridyl)ethane cobalt(II) chloride

Some iron(II), cobalt(II) and copper(II) complexes of the hybrid ligand 1-(diphenylphosphino)-2-(2-pyridyl)ethane (dppe) and diphenyl-2-pyridylphosphine (dppp) have been synthesised and characterised. Analyses suggest tetrahedral structures in which the metal atoms are bonded to two chlorine atoms and to both phosphorus and nitrogen atoms for 1-(diphenylphosphino)-2-(2-pyridyl)ethane on one hand and on the other hand, bonding is through the nitrogen atoms of two molecules of diphenyl-2-pyridylphosphine, which acts as a monodentate ligand. The crystal structure of 1-(diphenylphosphino)-2-(2-pyridyl)ethane cobalt(II) chloride shows a pseudo-tetrahedral structure in which the aminophosphine is bonded to the cobalt centre through both the phosphorus and nitrogen atoms, forming a 6-membered ring. KEY WORDS: Aminophosphines, Metal complexes, Cobalt(II) complex, Crystal structure  Bull. Chem. Soc. Ethiop. 2008, 22(2), 253-260

Characterization of copy number alterations in a mouse model of fibrosis-associated hepatocellular carcinoma reveals concordance with human disease

AbstractHepatocellular carcinoma (HCC) is a prevalent human cancer with rising incidence worldwide. Human HCC is frequently associated with chronic liver inflammation and cirrhosis, pathophysiological processes that are a consequence of chronic viral infection, disturbances in metabolism, or exposure to chemical toxicants. To better characterize the pathogenesis of HCC, we used a human disease‐relevant mouse model of fibrosis‐associated hepatocarcinogenesis. In this model, marked liver tumor response caused by the promutagenic chemical N‐nitrosodiethylamine in the presence of liver fibrosis was associated with epigenetic events indicative of genomic instability. Therefore, we hypothesized that DNA copy number alterations (CNAs), a feature of genomic instability and a common characteristic of cancer, are concordant between human HCC and mouse models of fibrosis‐associated hepatocarcinogenesis. We evaluated DNA CNAs and changes in gene expression in the mouse liver (normal, tumor, and nontumor fibrotic tissues). Additionally, we compared our findings to DNA CNAs in human HCC cases (tumor and nontumor cirrhotic/fibrotic tissues) using publicly available data from The Cancer Genome Atlas (TCGA). We observed that while fibrotic liver tissue is largely devoid of DNA CNAs, highly frequently occurring DNA CNAs are found in mouse tumors, which is indicative of a profound increase in chromosomal instability in HCC. The cross‐species gene‐level comparison of CNAs identified shared regions of CNAs between human fibrosis‐ and cirrhosis‐associated liver tumors and mouse fibrosis‐associated HCC. Our results suggest that CNAs most commonly arise in neoplastic tissue rather than in fibrotic or cirrhotic liver, and demonstrate the utility of this mouse model in replicating the molecular features of human HCC

Macroscopic Quantum Tunneling of a Domain Wall in a Ferromagnetic Metal

The macroscopic quantum tunneling of a planar domain wall in a ferromagnetic metal is studied based on the Hubbard model. It is found that the ohmic dissipation is present even at zero temperature due to the gapless Stoner excitation, which is the crucial difference from the case of the insulating magnet. The dissipative effect is calculated as a function of width of the wall and is shown to be effective in a thin wall and in a weak ferromagnet. The results are discussed in the light of recent experiments on ferromagnets with strong anisotropy. PACS numbers:75.60.Ch, 03.65.Sq, 75.10.LpComment: 13page

Influence of Nd on the magnetic properties of Nd1-xCaxMnO3

The role played by the Nd ions in the magnetic properties of Nd0.5Ca0.5MnO3 and Nd0.7Ca0.3MnO3 is studied using static magnetization, neutron diffraction and high frequency (9.4-475GHz) Electron Spin Resonance. We show that the Nd ions are weakly coupled to the Mn ions via ferromagnetic exchange and are responsible for the peculiar ferromagnetic resonance observed in the FM phase of both compounds (ground state below 120K for x=0.3, high field state for x=0.5). We then use ESR to look for magnetic phase separation in the low field, CO phase of Nd0.5Ca0.5MnO3. We show that there is no trace of the FM phase imbedded in the CO phase, contrary to what is observed in La0.5Ca0.5MnO3 or Pr0.5Sr0.5MnO3.Comment: to be published in phys.Rev.B as a Rapid Com

Charge-Density-Wave Formation in the Doped Two-Leg Extended Hubbard Ladder

We investigate electronic properties of the doped two-leg Hubbard ladder with both the onsite and the nearest-neighbor Coulomb repulsions, by using the the weak-coupling renormalization-group method. It is shown that, for strong nearest-neighbor repulsions, the charge-density-wave state coexisting with the p-density-wave state becomes dominant fluctuation where spins form intrachain singlets. By increasing doping rate, we have also shown that the effects of the nearest-neighbor repulsions are reduced and the system exhibits a quantum phase transition into the d-wave-like (or rung-singlet) superconducting state. We derive the effective fermion theory which describes the critical properties of the transition point with the gapless excitation of magnon. The phase diagram of the two-leg ladder compound, Sr_{14-x}Ca_xCu_{24}O_{41}, is discussed.Comment: 4 pages, 2 figure

Electronic Structure of Ladder Cuprates

We study the electronic structure of the ladder compounds (SrCa)CuO 14-24-41 and SrCuO 123. LDA calculations for both give similar Cu 3d-bands near the Fermi energy. The hopping parameters estimated by fitting LDA energy bands show a strong anisotropy between the t_perp t_par intra-ladder hopping and small inter-ladder hopping. A downfolding method shows that this anisotropy arises from the ladder structure.The conductivity perpendicular to the ladders is computed assuming incoherent tunneling giving a value close to experiment.Comment: 5 pages, 3 figure

Minhocas exóticas como indicadoras de perturbação antrópica em áreas de floresta atlântica.

No presente trabalho verificou-se o efeito de perturbação antrópica na incidência de minhocas exóticas e nativas ativas na superfície do solo de uma área de Floresta Atlântica do Estado de São Paulo, Brasil. Os oligoquetos foram amostrados usando armadilhas de queda (pitfall) em duas áreas, uma onde houve corte raso e queima, e outra onde houve corte seletivo de espécies lenhosas. A maior parte dos indivíduos (91,4%) foi amostrada na área onde houve corte raso e queima, e todos eram espécies exóticas (Amynthas sp., A. gracilis, A. corticis) ou peregrinas (Pontoscolex corethrurus). O contraste no número de indivíduos entre as duas áreas sugere que a perturbação antrópica influencia a atividade superficial e a abundância das espécies exóticas de minhocas e que estas apresentam potencial de uso como indicadores biológicos

Classical and Quantum Solutions and the Problem of Time in R2R^2 Cosmology

We have studied various classical solutions in $R^2$ cosmology. Especially we have obtained general classical solutions in pure $R^2$\ cosmology. Even in the quantum theory, we can solve the Wheeler-DeWitt equation in pure $R^2$\ cosmology exactly. Comparing these classical and quantum solutions in $R^2$\ cosmology, we have studied the problem of time in general relativity.Comment: 17 pages, latex, no figure, one reference is correcte

Dynamics of spin ladders

We derive an approximate theory for Heisenberg spin ladders with two legs by mapping the spin dynamics onto the problem of hard-core `bond-Bosons'. The parameters of the Bosonic Hamiltonian are obtained by matching anomalous Green's functions to Lanczos results and we find evidence for a strong renormalization due to quantum fluctuations. Various dynamical spin correlation functions are calculated and found to be in good agreement with Lanczos results. We then enlarge the effective Hamiltonian to describe the coupling of the bond-Bosons to a single hole injected into the system and treat the hole-dynamics within the `rainbow-diagram' approximation by Schmidt-Rink et. al. Theoretical predictions for the single hole spectral function are obtained and found to be in good agreement with Lanczos results.Comment: RevTex-file, 10 PRB pages with 7 eps files. Hardcopies of figures (or the entire manuscript) can be obtained by e-mail request to: [email protected]