A One Health Approach to Hypertrophic Cardiomyopathy.

Hypertrophic cardiomyopathy (HCM) is the most common inherited cardiac disease in humans and results in significant morbidity and mortality. Research over the past 25 years has contributed enormous insight into this inherited disease particularly in the areas of genetics, molecular mechanisms, and pathophysiology. Our understanding continues to be limited by the heterogeneity of clinical presentations with various genetic mutations associated with HCM. Transgenic mouse models have been utilized especially studying the genotypic and phenotypic interactions. However, mice possess intrinsic cardiac and hemodynamic differences compared to humans and have limitations preventing their direct translation. Other animal models of HCM have been studied or generated in part to overcome these limitations. HCM in cats shows strikingly similar molecular, histopathological, and genetic similarities to human HCM, and offers an important translational opportunity for the study of this disease. Recently, inherited left ventricular hypertrophy in rhesus macaques was identified and collaborative investigations have been conducted to begin to develop a non-human primate HCM model. These naturally-occurring large-animal models may aid in advancing our understanding of HCM and developing novel therapeutic approaches to this disease. This review will highlight the features of HCM in humans and the relevant available and developing animal models of this condition

NMR relaxation and resistivity from rattling phonons in pyrochlore superconductors

We calculate the temperature dependence of NMR relaxation rate and electrical resistivity for coupling to a local, strongly anharmonic phonon mode. We argue that the two-phonon Raman process is dominating NMR relaxation. Due to the strong anharmonicity of the phonon an unusual temperature dependence is found having a low temperature peak and becoming constant towards higher temperatures. The electrical resistivity is found to vary like T^2 at low temperatures and following a sqrt{T} behavior at high temperatures. Both results are in qualitative agreement with recent observations on beta-pyrochlore oxide superconductors.Comment: 4 pages, 4 figures; new version with some minor additional clarifications; accepted for publication in Phys. Rev. Let

Phonon Spectroscopy by Electric Measurements of Coupled Quantum Dots

We propose phonon spectroscopy by electric measurements of the low-temperature conductance of coupled-quantum dots, specifically employing dephasing of the quantum electronic transport by the phonons. The setup we consider consists of a T-shaped double-quantum-dot (DQD) system in which only one of the dots (dot 1) is connected to external leads and the other (dot 2) is coupled solely to the first one. For noninteracting electrons, the differential conductance of such a system vanishes at a voltage located in-between the energies of the bonding and the anti-bonding states, due to destructive interference. When electron-phonon (e-ph) on the DQD is invoked, we find that, at low temperatures, phonon emission taking place on dot 1 does not affect the interference, while phonon emission from dot 2 suppresses it. The amount of this suppression, as a function of the bias voltage, follows the effective e-ph coupling reflecting the phonon density of states and can be used for phonon spectroscopy.Comment: 9 pages, 6 figure

Density-Matrix Renormalization Group Study of Trapped Imbalanced Fermi Condensates

The density-matrix renormalization group is employed to investigate a harmonically-trapped imbalanced Fermi condensate based on a one-dimensional attractive Hubbard model. The obtained density profile shows a flattened population difference of spin-up and spin-down components at the center of the trap, and exhibits phase separation between the condensate and unpaired majority atoms for a certain range of the interaction and population imabalance $P$. The two-particle density matrix reveals that the sign of the order parameter changes periodically, demonstrating the realization of the Fulde-Ferrell-Larkin-Ovchinnikov phase. The minority spin atoms contribute to the quasi-condensate up to at least $P \simeq 0.8$. Possible experimental situations to test our predictions are discussed.Comment: 4 pages, 3 figures; added references; accepted for publication in Phys. Rev. Let

Nonunitary quantum circuit

A quantum circuit is generalized to a nonunitary one whose constituents are nonunitary gates operated by quantum measurement. It is shown that a specific type of one-qubit nonunitary gates, the controlled-NOT gate, as well as all one-qubit unitary gates constitute a universal set of gates for the nonunitary quantum circuit, without the necessity of introducing ancilla qubits. A reversing measurement scheme is used to improve the probability of successful nonunitary gate operation. A quantum NAND gate and Abrams-Lloyd's nonlinear gate are analyzed as examples. Our nonunitary circuit can be used to reduce the qubit overhead needed to ensure fault-tolerant quantum computation.Comment: 19 pages, 6 figures; added a referenc

Einstein--de Haas Effect in Dipolar Bose-Einstein Condensates

The general properties of the order parameter for a dipolar spinor Bose-Einstein condensate are discussed based on symmetries of interactions. An initially spin-polarized dipolar condensate is shown to dynamically generate a non-singular vortex via spin-orbit interactions -- a phenomenon reminiscent of the Einstein--de Haas effect in ferromagnets.Comment: 4 pages, 4 figures; Final versio

Pressure-induced changes in the optical properties of quasi-one-dimensional β\beta-Na0.33_{0.33}V2_2O5_5

The pressure-induced changes in the optical properties of $\beta$-Na$_{0.33}$V$_2$O$_5$ single crystals at room temperature were studied by polarization-dependent Raman and far-infrared reflectivity measurements under high pressure. From the changes in the Raman- and infrared-active phonon modes in the pressure range 9 - 12 GPa a transfer of charge between the different V sites can be inferred. The importance of electron-phonon coupling in the low-pressure regime is discussed.Comment: 7 pages, 5 figure