Influence of nanosilver on osmotic fragility responses of erythrocyte membrane following Na+/K+-ATPase blockade

Background: The molecular mechanisms and overt effects of nanoparticle-induced changes in red blood cells (RBCs) structure and function across membrane cell lines remain unclear despite the increasing use and application in nanomedicine. The aim of this study was to assess the impact of nanosilver exposure on osmoregulation of red cell membrane fragility in digoxin-induced Na+-K+ATPase blockade in vitro. Materials and Method: Samples from 50 subjects were obtained from consenting asymptomatic adults: male and female HbAA haemoglobin genotype. After separation and washing of erythrocytes, the samples were divided into three sets with each sample treated in duplicate with graded percentage concentrations of phosphate buffer solutions (0.9, 0.8, 0.7, 0.6, 0.5, 0.4, 0.3, 0.2, and 0.1). The second and third set of samples were incubated with 0.05ml of erythrocytes, 1 ml phosphate buffer saline and 1 ml nanosilver or digoxin of 25 mg/ml. Thereafter, the content of each test tube was incubated for 1 hour and 3 hours respectively. The absorbance was recorded after 30mins incubation for each set with standard spectrophotometer at 540 nm wavelength. Haemolysis in each tube was recorded and expressed as percentage of the absorbance in distilled water. The average values recorded were plotted against the different  concentrations used. Results: Erythrocytes from the sample incubated with nanosilver had significantly increased osmotic lysis compared with the untreated cells in rate-depended manner (P<0.05). Similar pattern was observed with digoxin pre-incubated cells. The mean osmotic fragility (MOF) index of the untreated, nanosilver and digoxin pre-incubated cells was in the order: digoxin>nanosilver>untreated. Conclusion: exposure of RBCs to nanosilver and in Na+/K+ATPase blockade may result in increased hemolytic effects by multifactorial cell membrane-mediated processe

Sense perception and the problem of illusion

This paper is a study of the problem of illusion in sense perception, using the methods of critical exposition and content analysis as tools of engagement. For decades, post-modern epistemology was steeped in the murky waters of the brilliant, skeptic argument from illusion, according to which the senses could not be relied upon for knowledge of the external world of reality, due to problems believed to be inherent in sensory perception. Why was the argument from illusion so important to epistemologists as to elicit enormous interest for such a long time? What are the implications of the argument for science? Did the argument from illusion portend any real danger for the foundations of empirical knowledge claims, as supposed by many frontline epistemologists? Exploring the concept and science of perceptual illusion, and the implications of the argument from illusion for science and epistemology, the paper found that the argument failed as a refutation of direct realism because it views illusion as the norm rather than an exception, and portrays human knowing process as an automatic, rather than a procedural, gradual phenomenon.Keywords: argument from illusion, empiricism, epistemology, science, skepticis

Local exergy cost analysis of cullet glass heating by microwaves

In this paper, the analysis of the local exergy costs of a cullet glass heated by microwaves in a cubical cavity activated by a susceptor is presented. The analysis is based on a previously validated 3-D electromagnetic model, but goes further by applying the concepts of local exergy efficiency and local unit exergy consumption, what enables a local analysis (in time and space) of the process efficiency. Furthermore, local exergy cost quantifies in detail the path of the exergy cost formation during microwave heating, which is determined by the local irreversibilities taking place in this transient process. Four different susceptor positions have been also compared, in order to find out not only which one is the most efficient but also to justify in detail this result by the time and space evolution of efficiency, unit exergy consumption (both external microwave power and conduction contributions) and unit exergy cost. The best conclusion of the paper is that the local exergy cost approach can contribute to the design of more efficient energy conversion systems, as it could be noted in its application to a complex process like this 3-D example of microwave cullet heating

A hermeneutic approach to the problem of illusion in sense perception

This paper is a hermeneutic exposition of the problem of illusion in sense perception, using the methods of critical and content analysis as tool of engagement. For decades, post-modern epistemology was steeped in the murky waters of the brilliant, sceptic argument from illusion, according to which the senses could not be relied upon for knowledge of the external world of reality, due to problems believed to be inherent in sensory perception. Why was the argument from illusion so important to epistemologists as to elicit enormous interest for such a long time? What are the implications of the argument for science? Did the argument from illusion portend any real danger for the foundations of empirical knowledge claims, as supposed by many frontline epistemologists? Exploring the concept and science of perceptual illusion, and the implications of the argument from illusion for science and epistemology, the paper found that the argument failed as a refutation of direct realism because it views illusion as the norm rather than an exception, and portrays human knowing process as an automatic, rather than a procedural, gradual phenomenon.Keywords: Argument from Illusion, Empiricism, Epistemology, Science, Scepticis

Knowledge, Attitude and practices of HIV post exposure prophylaxis amongst health workers in Lagos University teaching hospital

Introduction: timely PEP after needle stick exposure to high risk body fluids can reduce the rate of occupational transmission significantly. Ignorance of this may increase the risk of seroconversion to HIV for healthcare workers. This study was conducted with the aim of demonstrating the current level of knowledge and practise of healthcare workers as regards PEP. Methods: this was a cross-sectional study, pretested questionnaire were self administered to 372 health workers from various clinical specialties. The responses were collated and analyzed; results were presented in frequency tables. Results: this study revealed a high level of awareness among the respondents as 83.3% were aware of PEP. Despite the high level of awareness, respondents still have an inadequate knowledge about PEP, only 32% of the respondents could name at least two of the recommended drugs for PEP, only 54.0% of respondents knew when to commence PEP following occupational exposure to HIV. There was a low level of practice of PEP among the respondents as only 6.3% of respondents had PEP despite occurrence of needle stick injury. Conclusion: this study revealed a general low level use of PEP despite the average knowledge of PEP and the favourable attitude towards HIV PEP amongst the respondents

Retrospective Study of Inspectors Competency in the Act of Writing GMP Inspection Report

The research was a retrospective study of twenty-five Good Manufacturing Practice (GMP) inspection reports (from March 2017 through to December 2018) of a national medicine regulatory agency, drug Inspectorate, in West Africa, designed to assess the inspectors’ expertise in the act of inspection report writing. The investigation examined a paper-based tool of thirteen pre-registration Inspection reports and twelve GMP reassessment reports written prior and following an intervention program by external GMP trainers to enhance inspectors’ skill in pharmaceutical cGMP inspection. The study made use of quantitative analysis to investigate each team’s expertise in the act of writing GMP inspection report. Likewise, each report’s compliance with the requirements of three regulatory standards on GMP inspection report writing was ascertained. Impact of intervention program on lead inspectors’ competence was assessed. Lastly, gap in each team writing effectiveness, and lead inspectors’ abilities to deliver an effective report were determined. The results showed one of the inspection team (4.0%) wrote an excellent report. Two (8.0%) of the twenty-five inspection teams penned good inspection reports. Eleven (44.0%) teams drafted needs improvement reports and the remaining eleven teams (44.0%) prepared unacceptable reports. The excellent report and the two good reports had report format that meet expectation. One (50.0%) of the good reports showed the authors possess excellent knowledge of cGMP technical areas. The remain good report (50.0%) revealed the writers’ knowledge.as good. The excellent report showed the authors displayed partial mastery in the use of objective evidence while the two good reports disclosed theirs as having partial and evolving abilities. One of the teams (50.0%) that wrote good reports displayed good use of third person narrative past tense in report writing whereas the other team used the same tense and voice excellently. Generally, a sort of marginal level of performance was prominent among the inspection teams. A gap, if not tackled, will slow down regulatory process through increase report review, litigations that query report factual accuracy (AIHO, 2017) and delay in issuance of marketing authorization. In conclusion, trainings on quality attributes, such as technical content (Quality Management System (QMS) and Site), the use of objective evidence, assignment of risk levels to GMP violations and citing of applicable laws, regulation and guidelines that substantiate GMP observations, were recommended, to enhance knowledge sharing and regulators’ performance in the act of writing inspection report

Credit Risk Mitigation with Real Estate Collaterals in Nigeria’s Commercial Banks

The practice of posting collaterals to mitigate credit risk is commonplace in bank lending. Real estate is an important collateral instrument especially in developing countries. This study investigated credit risk mitigation with real estate collaterals by commercial banks in Nigeria to establish if real estate is a reliable collateral instrument, the role of real estate valuation and the key issues the banks consider in the process. Response was elicited from a sample of commercial banks in a cross-sectional survey with a structured questionnaire. Data analysis employed descriptive statistics. Findings indicate that real estate is a very reliable collateral instrument and that its valuation is a significant aspect of the risk mitigation process. The reliability of valuation opinion is the most important expectation of the banks from the valuers and the banks are satisfied with valuation advice provided by valuation firms. The banks consider the reputation of the borrower the most important factor to mitigate credit risk with real estate collateral and the quality of borrower’s title to the real estate the most important aspect of the collateral instrument for risk mitigation. Overall, the findings suggest negligence and inadequate due diligence on the part of the banks in the process of credit risk mitigation with real estate collaterals. There is need for adequate documentation of real estate titles and transactions for more efficient risk mitigation practice. Key words: Bank lending, Credit risk mitigation, Collateral, Nigeria; Real estate, Secured lendin

Inclusive Education and Sustainable Peace in Africa

Inclusive education is an innovative approach to education by which all children, youths and adults on the globe have equal opportunities to learn comfortably in the same academic environment regardless their intellectual and physical ability/disability and irrespective of their political, ethnic and socio-economic background. It is a brain child of UNESCO (the United Nations Educational Scientific and Cultural Organization); part of its Education For All (EFA) initiative which seeks to overcome the global challenges of marginalization, discrimination and exclusion. In this light, this paper examines the concept of inclusive education as a means of attaining long-lasting peace in Africa, which in turn will rekindle socio-economic and political progress. The paper provides copious evidence of the fact that socio-economic and political exclusion and marginalization are major sources of conflict and instability in Africa. Its underlying assumption is that inclusive education is a sure means of attaining optimum integral development and sustainable peace in Africa. Keywords: Inclusive education, sustainable peace in Afric