1,175 research outputs found
Water diffusion modulates the cest effect on Tb(III)-mesoporous silica probes
The anchoring of lanthanide(III) chelates on the surface of mesoporous silica nanoparticles (MSNs) allowed their investigation as magnetic resonance imaging (MRI) and chemical exchange saturation transfer (CEST) contrast agents. Since their efficiency is strongly related to the interaction occurring between Ln-chelates and \u201cbulk\u201d water, an estimation of the water diffusion inside MSNs channels is very relevant. Herein, a method based on the exploitation of the CEST properties of TbDO3A-MSNs was applied to evaluate the effect of water diffusion inside MSN channels. Two MSNs, namely MCM-41 and SBA-15, with different pores size distributions were functionalized with TbDO3A-like chelates and polyethylene glycol (PEG) molecules and characterized by HR-TEM microscopy, IR spectroscopy, N2 physisorption, and thermogravimetric analysis (TGA). The different distribution of Tb-complexes in the two systems, mainly on the external surface in case of MCM-41 or inside the internal pores for SBA-15, resulted in variable CEST efficiency. Since water molecules diffuse slowly inside silica channels, the CEST effect of the LnDO3A-SBA-15 system was found to be one order of magnitude lower than in the case of TbDO3A-MCM-41. The latter system reaches an excellent sensitivity of ca. 55 \ub1 5 \ub5M, which is useful for future theranostic or imaging applications
The M4 Core Project with HST --- I. Overview and First-Epoch
We present an overview of the ongoing Hubble Space Telescope large program
GO-12911. The program is focused on the core of M4, the nearest Galactic
globular cluster, and the observations are designed to constrain the number of
binaries with massive companions (black holes, neutron stars, or white dwarfs)
by measuring the ``wobble'' of the luminous (main-sequence) companion around
the center of mass of the pair, with an astrometric precision of ~50
micro-arcseconds. The high spatial resolution and stable medium-band PSFs of
WFC3/UVIS will make these measurements possible. In this work we describe: (i)
the motivation behind this study, (ii) our observing strategy, (iii) the many
other investigations enabled by this unique data set, and which of those our
team is conducting, and (iv) a preliminary reduction of the first-epoch
data-set collected on October 10, 2012.Comment: 25 pages, 14 figures (9 at low resolution), 3 tables. Published in:
Astronomische Nachrichten, Volume 334, Issue 10, pages 1062-1085, December
2013. http://onlinelibrary.wiley.com/doi/10.1002/asna.201311911/abstrac
M4 Core Project with HST - III. Search for variable stars in the primary field
We present the results of a photometric search for variable stars in the core
of the Galactic globular cluster M4. The input data are a large and
unprecedented set of deep Hubble Space Telescope WFC3 images (large program
GO-12911; 120 orbits allocated), primarily aimed at probing binaries with
massive companions by detecting their astrometric wobbles. Though these data
were not optimised to carry out a time-resolved photometric survey, their
exquisite precision, spatial resolution and dynamic range enabled us to firmly
detect 38 variable stars, of which 20 were previously unpublished. They include
19 cluster-member eclipsing binaries (confirming the large binary fraction of
M4), RR Lyrae, and objects with known X-ray counterparts. We improved and
revised the parameters of some among published variables.Comment: 11 pages, 5 figures, 2 tables. Accepted for publication in MNRA
The properties, origin and evolution of stellar clusters in galaxy simulations and observations
We investigate the properties and evolution of star particles in two simulations of isolated spiral galaxies, and two galaxies from cosmological simulations. Unlike previous numerical work, where typically each star particle represents one ‘cluster’, for the isolated galaxies we are able to model features we term ‘clusters’ with groups of particles. We compute the spatial distribution of stars with different ages, and cluster mass distributions, comparing our findings with observations including the recent LEGUS survey. We find that spiral structure tends to be present in older (100s Myrs) stars and clusters in the simulations compared to the observations. This likely reflects differences in the numbers of stars or clusters, the strength of spiral arms, and whether the clusters are allowed to evolve. Where we model clusters with multiple particles, we are able to study their evolution. The evolution of simulated clusters tends to follow that of their natal gas clouds. Massive, dense, long-lived clouds host massive clusters, whilst short-lived clouds host smaller clusters which readily disperse. Most clusters appear to disperse fairly quickly, in basic agreement with observational findings. We note that embedded clusters may be less inclined to disperse in simulations in a galactic environment with continuous accretion of gas onto the clouds than isolated clouds and correspondingly, massive young clusters which are no longer associated with gas tend not to occur in the simulations. Caveats of our models include that the cluster densities are lower than realistic clusters, and the simplistic implementation of stellar feedback
LEGUS and Halpha-LEGUS Observations of Star Clusters in NGC 4449: Improved Ages and the Fraction of Light in Clusters as a Function of Age
We present a new catalog and results for the cluster system of the starburst
galaxy NGC 4449 based on multi-band imaging observations taken as part of the
LEGUS and Halpha-LEGUS surveys. We improve the spectral energy fitting method
used to estimate cluster ages and find that the results, particularly for older
clusters, are in better agreement with those from spectroscopy. The inclusion
of Halpha measurements, the role of stochasticity for low mass clusters, the
assumptions about reddening, and the choices of SSP model and metallicity all
have important impacts on the age-dating of clusters. A comparison with ages
derived from stellar color-magnitude diagrams for partially resolved clusters
shows reasonable agreement, but large scatter in some cases. The fraction of
light found in clusters relative to the total light (i.e., T_L) in the U, B,
and V filters in 25 different ~kpc-size regions throughout NGC 4449 correlates
with both the specific Region Luminosity, R_L, and the dominant age of the
underlying stellar population in each region. The observed cluster age
distribution is found to decline over time as dN/dt ~ t^g, with g=-0.85+/-0.15,
independent of cluster mass, and is consistent with strong, early cluster
disruption. The mass functions of the clusters can be described by a power law
with dN/dM ~ M^b and b=-1.86+/-0.2, independent of cluster age. The mass and
age distributions are quite resilient to differences in age-dating methods.
There is tentative evidence for a factor of 2-3 enhancement in both the star
and cluster formation rate ~100 - 300 Myr ago, indicating that cluster
formation tracks star formation generally. The enhancement is probably
associated with an earlier interaction event
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