Assessing the true metabolizable energy value and digestibility of molasses in broiler diets

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Determinatiion of the true metabolizable energy value and digestibility of Sardine fish meal

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Performance of growing broiler chickens fed toasted and untoasted melon (Colocythis cirtullis) seed meal

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Chemical Composition and In Situ Dry Matter Digestibility of Selected Multi Purpose Trees and Schrubs

None Availabl

Bioavalable energy value and digestibility of whole melon seedmeal (Colocynthis citrullus, L). in broiler chickens

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Cane molasses in diets of growing broiler chickens

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Increased paired box transcription factor 8 has a survival function in Glioma

Background: The molecular basis to overcome therapeutic resistance to treat glioblastoma remains unclear. The anti-apoptotic b cell lymphoma 2 (BCL2) gene is associated with treatment resistance, and is transactivated by the paired box transcription factor 8 (PAX8). In earlier studies, we demonstrated that increased PAX8 expression in glioma cell lines was associated with the expression of telomerase. In this current study, we more extensively explored a role for PAX8 in gliomagenesis. Methods: PAX8 expression was measured in 156 gliomas including telomerase-negative tumours, those with the alternative lengthening of telomeres (ALT) mechanism or with a non-defined telomere maintenance mechanism (NDTMM), using immunohistochemistry and quantitative PCR. We also tested the affect of PAX8 knockdown using siRNA in cell lines on cell survival and BCL2 expression. Results: Seventy-two percent of glioblastomas were PAX8-positive (80% telomerase, 73% NDTMM, and 44% ALT). The majority of the low-grade gliomas and normal brain cells were PAX8-negative. The suppression of PAX8 was associated with a reduction in both cell growth and BCL2, suggesting that a reduction in PAX8 expression would sensitise tumours to cell death. Conclusions: PAX8 is increased in the majority of glioblastomas and promoted cell survival. Because PAX8 is absent in normal brain tissue, it may be a promising therapeutic target pathway for treating aggressive gliomas