The SIB Swiss Institute of Bioinformatics' resources: focus on curated databases

The SIB Swiss Institute of Bioinformatics (www.isb-sib.ch) provides world-class bioinformatics databases, software tools, services and training to the international life science community in academia and industry. These solutions allow life scientists to turn the exponentially growing amount of data into knowledge. Here, we provide an overview of SIB's resources and competence areas, with a strong focus on curated databases and SIB's most popular and widely used resources. In particular, SIB's Bioinformatics resource portal ExPASy features over 150 resources, including UniProtKB/Swiss-Prot, ENZYME, PROSITE, neXtProt, STRING, UniCarbKB, SugarBindDB, SwissRegulon, EPD, arrayMap, Bgee, SWISS-MODEL Repository, OMA, OrthoDB and other databases, which are briefly described in this article

Analysis of the thorium axial blanket experiments in the PROTEUS reactor

An extensive program of reactor physics experiments in GCFR fuel pin lattices has been completed recently at the PROTEUS critical facility located at EIR laboratory in Switzerland. The PROTEUS reactor consists of a central test zone surrounded by a uranium buffer and thermal driver region. The test lattices included a PuO/sub 2//UO/sub 2/ fuel region with internal and axial blankets of UO/sub 2/, ThO/sub 2/, and thorium metal. Detailed analysis of the thorium-bearing lattices has been performed at EIR and at ORNL in order to validate nuclear data and methods used for reactor physics analysis of advanced GCFR designs

Integral testing of 237Np cross-sections in GCFR spectra

Integral measurements of 237Np capture and fission rates have been carried out relative to the 239Pu fission rate in two GCFR lattices with different neutron spectra. The results have been compared with calculated values based, respectively, on ENDF/B-IV and FGL5 cross-sections. Both data sets predicted the measured fission ratios correctly within the experimental errors of ±2% but, in the case of the ratio of 237Np capture to 239Pu fission, the calculated ratios differed from the measured values by about 10% for both sets. © 1979

Attacker-defender models and road network vulnerability

The reliability of road networks depends directly on their vulnerability to disruptive incidents, ranging in severity from minor disruptions to terrorist attacks. This paper presents a game theoretic approach to the analysis of road network vulnerability. The approach posits predefined disruption, attack or failure scenarios and then considers how to use the road network so as to minimize the maximum expected loss in the event of one of these scenarios coming to fruition. A mixed route strategy is adopted, meaning that the use of the road network is determined by the worst scenario probabilities. This is equivalent to risk-averse route choice. A solution algorithm suitable for use with standard traffic assignment software is presented, thereby enabling the use of electronic road navigation networks. A variant of this algorithm suitable for risk-averse assignment is developed. A numerical example relating to the central London road network is presented. The results highlight points of vulnerability in the road network. Applications of this form of network vulnerability analysis together with improved solution methods are discussed

Combined impact of negative lifestyle factors on cardiovascular risk in children: a randomized prospective study.

PURPOSE: Negative lifestyle factors are known to be associated with increased cardiovascular risk (CVR) in children, but research on their combined impact on a general population of children is sparse. Therefore, we aimed to quantify the combined impact of easily assessable negative lifestyle factors on the CVR scores of randomly selected children after 4 years. METHODS: Of the 540 randomly selected 6- to 13-year-old children, 502 children participated in a baseline health assessment, and 64% were assessed again after 4 years. Measures included anthropometry, fasting blood samples, and a health assessment questionnaire. Participants scored one point for each negative lifestyle factor at baseline: overweight; physical inactivity; high media consumption; little outdoor time; skipping breakfast; and having a parent who has ever smoked, is inactive, or overweight. A CVR score at follow-up was constructed by averaging sex- and age-related z-scores of waist circumference, blood pressure, glucose, inverted high-density lipoprotein, and triglycerides. RESULTS: The age-, sex-, pubertal stage-, and social class-adjusted probabilities (95% confidence interval) for being in the highest CVR score tertile at follow-up for children who had at most one (n = 48), two (n = 64), three (n = 56), four (n = 41), or five or more (n = 14) risky lifestyle factors were 15.4% (8.9-25.3), 24.3% (17.4-32.8), 36.0% (28.6-44.2), 49.8% (38.6-61.0), and 63.5% (47.2-77.2), respectively. CONCLUSIONS: Even in childhood, an accumulation of negative lifestyle factors is associated with higher CVR scores after 4 years. These negative lifestyle factors are easy to assess in clinical practice and allow early detection and prevention of CVR in childhood