389 research outputs found
Rostral locus coeruleus integrity is associated with better memory performance in older adults
The Center of Lifespan Psychology at the Max Planck Institute for Human Development : Conceptual agenda and illustration of research activities
Multimodal assessment of locus coeruleus integrity is associated with late-life memory performance
THU0366 SYSTEMATIC CORONARY RISK EVALUATION (SCORE) MISCLASSIFIES CARDIOVASCULAR RISK IN ANTISYNTHETASE SYNDROME: RESULTS OF THE PILOT MULTICENTRIC STUDY RI.CAR.D.A.
Background:Antisynthetase Syndrom (ASyS) is an autoimmune overlap disease characterized by antiaminoacyl-tRNA-synthetase (anti-ARS) antibodies and the classic triad of arthritis, myositis and interstitial lung disease (ILD) (1). Markers of cardiovascular (CV) or cerebrovascular (CVB) risk have never been examined in ASyS.Objectives:Aim of this study (RIsk of CARdiovascular Disease in ASyS: RI.CAR.D.A.) was to test the ability of an established traditional CV risk prediction score (Systematic Coronary Risk Evaluation-SCORE) and its EULAR modified version (mSCORE) to identify ASyS patients at high CV risk. Moreover, we sought to examine for the first time associations of CV surrogate markers with clinical and immunological ASyS parameters.Methods:SCORE/mSCORE and the gold standard marker of aortic stiffness (carotid-femoral pulse wave velocity-cfPWV) were examined in patients with ASyS and healthy controls in a multicenter setting (6 Rheumatology Centers). Moreover, sonography of the common- (CCA), internal- (ICA) and external- (ECA) carotid arteries was performed in subsets of both groups, evaluating carotid intima-media-thickness (cIMT), plaques and duplex-sonographic indices of CBV risk such as the resistance- (RI) and pulsatility-index (PI).Figure 1.Carotid Doppler surrogate markers of cardiovascular and cerebrovascular risk in controls and ASyS (case).cIMTCarotid intima media thickness;CAA(common-),ICA(internal),ECA(external) carotid artery;RIresistance index;PIpulsatility index. (all;p0.9 mm) (SCA) in85.7%of the patients respectively. ROC analyses showed similarly poor diagnostic performances of SCORE/mSCORE in comparison to cfPWV(>10 m/s) and SAC by areas under the curve (AUC) of0.56 (95%CI=0.39-0.73) and0.63 (95%CI=0.3-0.96),respectively. cfPWV and SCA were higher in ASyS patients compared to controls (padj=0.021andp=0.003, respectively). cfPWV and cIMT correlated in the patient group significantly with age (r=0.679; p<0.001 and r=0.664; p<0.001,respectively).Moreover, cfPWV correlated with BMI (padj=0.001) and diabetes(padj=0.043). ACC-RI and ACC-PI showed significant associations with a marker of myositis activity [creatine phosphokinase (CPK):r=0.629;p=0.012andr=0.574;p=0.032, respectively]. Finally, ACI-RI and ACI-PI values were higher in patients with ILD (both;p=0.039).Conclusion:This is the first report of higher aortic stiffness and SCA in ASyS patients compared to controls. Active myositis and presence of ILD were associated with higher CVB risk parameters. Furthermore, SCORE/mSCORE performed poorly in identifying patients at high CV risk and carotid arteriosclerosis compared to cfPWV and CS respectively. Thus, cfPWV and CS could improve CV and CBV screening in ASyS patients.References:[1]Cavagna L, et al. Clinical Spectrum Time Course in Anti Jo-1 Positive Antisynthetase Syndrome.Medicine2015;94:1144.Disclosure of Interests:None declare
Low- and Medium-Dispersion Spectropolarimetry of Nova V475 Sct (Nova Scuti 2003): Discovery of an Asymmetric High-Velocity Wind in a Moderately Fast Nova
We present low-resolution () and medium-resolution ()
spectropolarimetry of Nova V475 Sct with the HBS instrument, mounted on the
0.91-m telescope at the Okayama Astrophysical Observatory, and with FOCAS,
mounted on the 8.2-m Subaru telescope. We estimated the interstellar
polarization toward the nova from the steady continuum polarization components
and H line emission components. After subtracting the interstellar
polarization component from the observations, we found that the H
emission seen on 2003 October 7 was clearly polarized. In the polarized flux
spectrum, the H emission had a distinct red wing extending to km s and a shoulder around km s, showing a
constant position angle of linear polarization \theta_{\rm *}\simeq
155\arcdeg\pm 15\arcdeg. This suggests that the nova had an asymmetric outflow
with a velocity of km s or more, which is six
times higher than the expansion velocity of the ionized shell at the same
epoch. Such a high-velocity component has not previously been reported for a
nova in the `moderately fast' speed class. Our observations suggest the
occurrence of violent mass-loss activity in the nova binary system even during
the common-envelope phase. The position angle of the polarization in the
H wing is in good agreement with that of the continuum polarization
found on 2003 September 26 (--0.6 %), which disappeared
within the following 2 d. The uniformity of the PA between the continuum
polarization and the wing polarization on October 7 suggests that the axis of
the circumstellar asymmetry remained nearly constant during the period of our
observations.Comment: 27 pages, 7 figures, accepted for publication in A
Ratio of kaon and pion leptonic decay constants with Wilson-clover twisted-mass fermions
We present a determination of the ratio of kaon and pion leptonic decay
constants in isosymmetric QCD (isoQCD), , making use of the gauge
ensembles produced by the Extended Twisted Mass Collaboration (ETMC) with flavors of Wilson-clover twisted-mass quarks, including
configurations close to the physical point for all dynamical flavors. The
simulations are carried out at three values of the lattice spacing ranging from
to fm with linear lattice size up to ~fm.
The scale is set by the PDG value of the pion decay constant, MeV, at the isoQCD pion point, MeV,
obtaining for the gradient-flow (GF) scales the values fm,
fm and fm. The data are
analyzed within the framework of SU(2) Chiral Perturbation Theory (ChPT)
without resorting to the use of renormalized quark masses. At the isoQCD kaon
point MeV we get , where the error includes both statistical and systematic
uncertainties. Implications for the Cabibbo-Kobayashi-Maskawa (CKM) matrix
element and for the first-row CKM unitarity are discussed.Comment: 68 pages, 14 figures, 12 tables. Version to appear in PR
- …