8 research outputs found

    Synthesis and evaluation of antiinflammatory, analgesic and ulcerogenic potential of NSAIDs bearing 1,3,4-oxadiazole scaffold

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    Synthesis of 1,3,4-oxadiazole derivatives of diclofenac and mefenamic acid are described. The target compounds 5-[2-(2,6-dichloroanilino)benzyl]-2-aryl-1,3,4-oxadiazole (3a-3e) and 5-[2-(2,3-dimethylanilino)phenyl]-2-(aryl)-1,3,4-oxadiazole (6a-6e) were obtained by treating 2 and 5 with various aromatic acids using POCl 3 as dehydrating agent. They were purified and characterized by IR, 1 H-NMR and elemental analysis. These compounds were further subjected to antiinflammatory, analgesic and acute ulcerogenic activity. Compound 3c and 6d exhibited good antiinflammatory activity and compounds 3c, 3e, 6c, 6d, 6e were found to be non ulcerogenic

    Epihalohydrins in organic synthesis

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    Genetic determinants of inherited susceptibility to hypercholesterolemia – a comprehensive literature review

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    Epihalohydrins in Organic Synthesis

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    Sulfamic Acid and Its N- and O-Substituted Derivatives

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    Chemotherapy and Other Control Measures of Parasitic Diseases in Domestic Animals and Man

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