4,934 research outputs found
A preclinical microbeam facility with a conventional x-ray tube.
Purpose Microbeam radiation therapy is an innovative treatment approach in radiation therapy that uses arrays of a few tens of micrometer wide and a few hundreds of micrometer spaced planar x-ray beams as treatment fields. In preclinical studies these fields efficiently eradicated tumors while normal tissue could effectively be spared. However, development and clinical application of microbeam radiation therapy is impeded by a lack of suitable small scale sources. Until now, only large synchrotrons provide appropriate beam properties for the production of microbeams.Methods In this work, a conventional x-ray tube with a small focal spot and a specially designed collimator are used to produce microbeams for preclinical research. The applicability of the developed source is demonstrated in a pilot in vitro experiment. The properties of the produced radiation field are characterized by radiochromic film dosimetry.Results 50 μm wide and 400 μm spaced microbeams were produced in a 20 × 20 mm2 sized microbeam field. The peak to valley dose ratio ranged from 15.5 to 30, which is comparable to values obtained at synchrotrons. A dose rate of up to 300 mGy/s was achieved in the microbeam peaks. Analysis of DNA double strand repair and cell cycle distribution after in vitro exposures of pancreatic cancer cells (Panc1) at the x-ray tube and the European Synchrotron leads to similar results. In particular, a reduced G2 cell cycle arrest is observed in cells in the microbeam peak region.Conclusions At its current stage, the source is restricted to in vitro applications. However, moderate modifications of the setup may soon allow in vivo research in mice and rats
The early X-ray afterglows of optically bright and dark Gamma-Ray Bursts
A systematical study on the early X-ray afterglows of both optically bright
and dark gamma-ray bursts (B-GRBs and D-GRBs) observed by Swift has been
presented. Our sample includes 25 GRBs. Among them 13 are B-GRBs and 12 are
D-GRBs. Our results show that the distributions of the X-ray afterglow fluxes
(), the gamma-ray fluxes (), and the ratio ()
for both the D-GRBs and B-GRBs are similar. The differences of these
distributions for the two kinds of GRBs should be statistical fluctuation.
These results indicate that the progenitors of the two kinds of GRBs are the
same population. Their total energy explosions are comparable. The suppression
of the optical emissions from D-GRBs should results from circumburst but not
their central engine.Comment: 10 pages, 3 figures, 1 table; accepted by ChJA
The Rotating-Wave Approximation: Consistency and Applicability from an Open Quantum System Analysis
We provide an in-depth and thorough treatment of the validity of the
rotating-wave approximation (RWA) in an open quantum system. We find that when
it is introduced after tracing out the environment, all timescales of the open
system are correctly reproduced, but the details of the quantum state may not
be. The RWA made before the trace is more problematic: it results in incorrect
values for environmentally-induced shifts to system frequencies, and the
resulting theory has no Markovian limit. We point out that great care must be
taken when coupling two open systems together under the RWA. Though the RWA can
yield a master equation of Lindblad form similar to what one might get in the
Markovian limit with white noise, the master equation for the two coupled
systems is not a simple combination of the master equation for each system, as
is possible in the Markovian limit. Such a naive combination yields inaccurate
dynamics. To obtain the correct master equation for the composite system a
proper consideration of the non-Markovian dynamics is required.Comment: 17 pages, 0 figures
Observations of the longitudinal spread of solar energetic particle events in solar cycle 24
With the twin STEREO spacecraft, significantly separated from L1-based satellites such as ACE, simultaneous multi-point measurements of solar energetic particle (SEP) events can be made for H-Fe ions from a few hundred keV/nuc to over 100 MeV/nuc and for electrons from tens to hundreds of keV. These observations allow studies of the longitudinal characteristics of SEP events to advance beyond statistical analysis of single point measurements. Although there have been few large SEP events thus far in cycle 24, there have been a number of smaller events that have been detected by more than one spacecraft. The composition of these SEP events, as indicated by the H/He and Fe/O abundance ratios, shows a dependence on longitudinal distance from the solar source in some events, at times with ratios varying by an order of magnitude. However, these variations are not organized by either the speed or width of the associated coronal mass ejections
A moving boundary model motivated by electric breakdown: II. Initial value problem
An interfacial approximation of the streamer stage in the evolution of sparks
and lightning can be formulated as a Laplacian growth model regularized by a
'kinetic undercooling' boundary condition. Using this model we study both the
linearized and the full nonlinear evolution of small perturbations of a
uniformly translating circle. Within the linear approximation analytical and
numerical results show that perturbations are advected to the back of the
circle, where they decay. An initially analytic interface stays analytic for
all finite times, but singularities from outside the physical region approach
the interface for , which results in some anomalous relaxation at
the back of the circle. For the nonlinear evolution numerical results indicate
that the circle is the asymptotic attractor for small perturbations, but larger
perturbations may lead to branching. We also present results for more general
initial shapes, which demonstrate that regularization by kinetic undercooling
cannot guarantee smooth interfaces globally in time.Comment: 44 pages, 18 figures, paper submitted to Physica
Galactic Abundances: Report of Working Group 3
We summarize the various methods and their limitations and strengths to derive galactic abundances from in-situ and remote-sensing measurements, both from ground-based observations and from instruments in space. Because galactic abundances evolve in time and space it is important to obtain information with a variety of different methods covering different regions from the Very Local Insterstellar Medium (VLISM) to the distant galaxy, and different times throughout the evolution of the galaxy. We discuss the study of the present-day VLISM with neutral gas, pickup ions, and Anomalous Cosmic Rays, the study of the local interstellar medium (ISM) at distances <1.5 kpc utilizing absorption line measurements in H I clouds, and the study of galactic cosmic rays, sampling contemporary (~15 Myr) sources in the local ISM within a few kiloparsec of the solar system. Solar system abundances, derived from solar abundances and meteorite studies are discussed in several other chapters of this volume. They provide samples of matter from the ISM from the time of solar system format ion, about 4.5 Gyr ago. The evolution of galactic abundances on longer time scales is discussed in the context of nuclear synthesis in the various contributing stellar objects
A moving boundary problem motivated by electric breakdown: I. Spectrum of linear perturbations
An interfacial approximation of the streamer stage in the evolution of sparks
and lightning can be written as a Laplacian growth model regularized by a
`kinetic undercooling' boundary condition. We study the linear stability of
uniformly translating circles that solve the problem in two dimensions. In a
space of smooth perturbations of the circular shape, the stability operator is
found to have a pure point spectrum. Except for the zero eigenvalue for
infinitesimal translations, all eigenvalues are shown to have negative real
part. Therefore perturbations decay exponentially in time. We calculate the
spectrum through a combination of asymptotic and series evaluation. In the
limit of vanishing regularization parameter, all eigenvalues are found to
approach zero in a singular fashion, and this asymptotic behavior is worked out
in detail. A consideration of the eigenfunctions indicates that a strong
intermediate growth may occur for generic initial perturbations. Both the
linear and the nonlinear initial value problem are considered in a second
paper.Comment: 37 pages, 6 figures, revised for Physica
Time preferences and risk aversion: tests on domain differences
The design and evaluation of environmental policy requires the incorporation of time and risk elements as many environmental outcomes extend over long time periods and involve a large degree of uncertainty. Understanding how individuals discount and evaluate risks with respect to environmental outcomes is a prime component in designing effective environmental policy to address issues of environmental sustainability, such as climate change. Our objective in this study is to investigate whether subjects' time preferences and risk aversion across the monetary domain and the environmental domain differ. Crucially, our experimental design is incentivized: in the monetary domain, time preferences and risk aversion are elicited with real monetary payoffs, whereas in the environmental domain, we elicit time preferences and risk aversion using real (bee-friendly) plants. We find that subjects' time preferences are not significantly different across the monetary and environmental domains. In contrast, subjects' risk aversion is significantly different across the two domains. More specifically, subjects (men and women) exhibit a higher degree of risk aversion in the environmental domain relative to the monetary domain. Finally, we corroborate earlier results, which document that women are more risk averse than men in the monetary domain. We show this finding to, also, hold in the environmental domain
Observation of exotic meson production in the reaction at 18 GeV/c
An amplitude analysis of an exclusive sample of 5765 events from the reaction
at 18 GeV/c is described. The
production is dominated by natural parity exchange and by
three partial waves: those with and . A
mass-dependent analysis of the partial-wave amplitudes indicates the production
of the meson as well as the meson, observed for the
first time decaying to . The dominant, exotic
(non- partial wave is shown to be resonant with a mass of
GeV/c^2 and a width of GeV/c^2 . This exotic state, the , is produced with a
dependence which is different from that of the meson, indicating
differences between the production mechanisms for the two states.Comment: 5 pages with 4 figure
Evidence for Exotic J^{PC}=1^{-+} Meson Production in the Reaction pi- p --> eta pi- p at 18 GeV/c
Details of the analysis of the eta pi- system studied in the reaction pi^{-}
p --> eta pi^{-} p at 18 GeV/c are given. Separate analyses for the 2 gamma and
pi+ pi- pi0 decay modes of the eta are presented. An amplitude analysis of the
data indicates the presence of interference between the a(2)(1320)- and a
J^{PC}=1^{-+} wave between 1.2 and 1.6 GeV/c^2. The phase difference between
these waves shows phase motion not attributable solely to the a(2)(1320)-. The
data can be fitted by interference between the a(2)(1320)- and an exotic 1^{-+}
resonance with M = 1370 +-16 +50 -30} MeV/c^2 and Gamma = 385 +- 40 +65 -105
MeV/c^2. Our results are compared with those of other experiments.Comment: 50 pages of text and 34 figure
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