Abstracts from the 20th International Symposium on Signal Transduction at the Blood-Brain Barriers

https://deepblue.lib.umich.edu/bitstream/2027.42/138963/1/12987_2017_Article_71.pd

Changes in pain intensity between baseline and 1 month after patch application presented as SPID for capsaicin and placebo patch treatments, and the mean difference.

<p>The SPID was calculated as the difference between the baseline SPI-value and the SPI-value at 1 month after patch application. Each SPI- value contains six median values (pain assessments twice daily for three days). Values are mean (95% CI). Positive values of SPID indicate pain reduction after treatment. <i>P</i>-values indicate comparisons of SPID (capsaicin <i>vs</i>. placebo).</p><p>NRS = Numerical Rating Scale (0–10), SPID = Summed pain intensity difference, SPI = summed pain intensity.</p><p>Changes in pain intensity between baseline and 1 month after patch application presented as SPID for capsaicin and placebo patch treatments, and the mean difference.</p

Baseline patient characteristics.

†<p>Mean (standard deviation).</p>‡<p>Median (25–75% interquartile range).</p>§<p>Pain-generating inguinal hernia operation.</p>¶<p>Pain ratings at baseline assessed at rest in the supine position, during transition from supine to standing position, and during the patient’s palpation of the point of maximum pain in the groin. Values are medians (25–75% interquartile range). Two patients who withdrew early from the study and one patient who was lost to follow-up did not report baseline pain ratings and were not included in the analyses of pain ratings.</p><p>BMI = Body Mass Index, NRS = Numerical Rating Scale (0–10), NSAIDs = Non-steroidal Anti-inflammatory Drugs.</p><p>Baseline patient characteristics.</p

Skin reactions at application site.

<p>Skin reactions at application site.</p

Differences in quantitative sensory assessments on the pain side from baseline to 1 month after patch application.

<p>Values are mean (95% CI)^§ or median (95% CI). Δ value = post-treatment minus baseline value. <i>P</i>-values indicate comparisons of Δ-values (capsaicin <i>vs</i>. placebo [unpaired t-test^‡ or the Mann-Whitney test). Positive Δ-values for WDT, HPT, PPT and CDT indicate increased thresholds after treatment.</p><p>WDT = warmth detection threshold, CDT = cool detection threshold, HPT = heat pain threshold, PPT = pressure pain threshold, STH = suprathreshold heat pain perception, NRS = Numerical Rating Scale (0–10).</p><p>Differences in quantitative sensory assessments on the pain side from baseline to 1 month after patch application.</p