Wireless Health Monitoring using Passive WiFi Sensing

This paper presents a two-dimensional phase extraction system using passive WiFi sensing to monitor three basic elderly care activities including breathing rate, essential tremor and falls. Specifically, a WiFi signal is acquired through two channels where the first channel is the reference one, whereas the other signal is acquired by a passive receiver after reflection from the human target. Using signal processing of cross-ambiguity function, various features in the signal are extracted. The entire implementations are performed using software defined radios having directional antennas. We report the accuracy of our system in different conditions and environments and show that breathing rate can be measured with an accuracy of 87% when there are no obstacles. We also show a 98% accuracy in detecting falls and 93% accuracy in classifying tremor. The results indicate that passive WiFi systems show great promise in replacing typical invasive health devices as standard tools for health care.Comment: 6 pages, 8 figures, conference pape

Keratin 19 expression correlates with poor prognosis in breast cancer

Breast cancer expression profiling has been used for determining biomarkers. Using gene expression profiles of 2,400 patients we identified keratin 19 (KRT19) as a highly deregulated gene in breast cancer. KRT19 expression is independent of patient race but correlates with disease grade, and ER, PR or HER2 expression. Expression of TPD52, GATA3 and KRT18 was increased in KRT19 expressing patients. Furthermore, KRT19 expression was associated with ER up-regulation and Luminal B gene signatures, as well as a constitutive RAF1 signaling pathway. Finally, KRT19 expression correlated with poor overall survival. Taken together, our results suggest that KRT19 expression can be used as a prognostic marker

Protein kinase C (PKC) as a drug target in chronic lymphocytic leukemia.

Protein kinase C (PKC) belongs to a family of ten serine/threonine protein kinases encoded by nine genes. This family of proteins plays critical roles in signal transduction which results in cell proliferation, survival, differentiation and apoptosis. Due to differential subcellular localization and tissue distribution, each member displays distinct signaling characteristics. In this review, we have summarized the roles of PKC family members in chronic lymphocytic leukemia (CLL). CLL is a heterogeneous hematological disorder with survival ranging from months to decades. PKC isoforms are differentially expressed in CLL and play critical roles in CLL pathogenesis. Thus, isoform-specific PKC inhibitors may be an attractive option for CLL treatment

Deregulation of protein phosphatase expression in acute myeloid leukemia

Acute myeloid leukemia (AML) is a highly malignant disease of myeloid cell line. AML is the most frequent adult leukemia with inadequate treatment possibility. The protein phosphatases are critical regulators of cell signaling, and deregulation of protein phosphatases always contribute to cell transformation. Although many studies established a relationship between protein phosphatases and leukemia, little is known about the role of this group of proteins in AML. To address this issue, we initially identified the complete catalog of human protein phosphatase genes and used this catalog to study deregulation of protein phosphatases in AML. Using mRNA expression data of AML patients, we show that 11 protein phosphatases are deregulated in AML within 174 protein phosphatases. The GO enrichment study suggests that these genes are involved in multiple biological processes other than protein de-phosphorylation. Expression of DUSP10, PTPRC, and PTPRE was significantly higher than average expression in AML, and a linear combination of DUSP10, MTMR11, PTPN4, and PTPRE expressions provides important information about disease subtypes. Our results provide an overview of protein phosphatase deregulation in AML

Active and Passive Quantum Erasers for Neutral Kaons

Quantum marking and quantum erasure are discussed for the neutral kaon system. Contrary to other two-level systems, strangeness and lifetime of a neutral kaon state can be alternatively measured via an "active" or a "passive" procedure. This offers new quantum erasure possibilities. In particular, the operation of a quantum eraser in the "delayed choice" mode is clearly illustrated.Comment: 17 pages, LaTeX, 1 figure, references added, accepted by Phys. Rev.

Bacteriological quality of water used for ice making in some parts of Kano metropolis, Nigeria

A study was carried out on the bacterial counts of water used for commercial production of ice. Total of twenty samples (ten raw water samples and ten ice samples) were collected at random from ten different locations, and subjected to aerobic mesophilic bacterial and coliform counts according to FAO/WHO standard methods for the examination of water and wastewater. The results showed that the raw water had mean aerobic plate count of 2.05 x 103 cfu/ml, coliform MPN ranged fro